azatoxin: structure given in first source; a topoisomerase II inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 125383 |
| CHEMBL ID | 275569 |
| SCHEMBL ID | 18793659 |
| MeSH ID | M0204539 |
| Synonym |
|---|
| azatoxin |
| CHEMBL275569 |
| 1h,3h-oxazolo(3',4':1,6)pyrido(3,4-b)indol-3-one, 5,6,11,11a-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r-cis)- |
| nsc 640737-m |
| 1h,6h-3-one-5,4,11,11a-tetrahydro-5-(3,5-dimethoxy-4-hydroxyphenyl)oxazolo(3',4'-1,6)pyrido(3,4-b)indole |
| nsc 640737 |
| (5r-cis)-5,6,11,11a-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-1h,3h-oxazolo(3',4':1,6)pyrido(3,4-b)indol-3-one |
| 129564-92-7 |
| SCHEMBL18793659 |
| 5-(4-hydroxy-3,5-dimethoxyphenyl)-5,6,11,11a-tetrahydro-1h,3h-[1,3]oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one |
| DTXSID40926432 |
| (10r,15s)-10-(4-hydroxy-3,5-dimethoxyphenyl)-13-oxa-8,11-diazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(9),2,4,6-tetraen-12-one |
| 1h,3h-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one, 5,6,11,11a-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r,11as)- |
| BT2674SA3S |
| (5r,11as)-5,6,11,11a-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-1h,3h-oxazolo[3',4':1,6]pyrido[3,4-b]indol-3-one |
Azatoxin (NSC 640737) is a synthetic molecule that was rationally designed as a topoisomerase II inhibitor.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Azatoxin (NSC 640737) is a synthetic molecule that was rationally designed as a topoisomerase II inhibitor (Leteurtre et al., Cancer Res 52: 4478-4483, 1992). " | ( Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent. Hamel, E; Leteurtre, F; Paull, KD; Pommier, Y; Scudiero, D; Solary, E, 1993) | 1.97 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID228427 | Compound was evaluated for its ability to affect topoisomerase II inhibition; active | 1998 | Bioorganic & medicinal chemistry letters, May-05, Volume: 8, Issue:9 | The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins. |
| AID143209 | Compound was evaluated for growth inhibition against NCI-H520 cells using cellular assay | 1998 | Bioorganic & medicinal chemistry letters, May-05, Volume: 8, Issue:9 | The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins. |
| AID1381552 | Cytotoxicity against human Capan1 cells after 48 hrs by XTT assay | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | New somatostatin-drug conjugates for effective targeting pancreatic cancer. |
| AID102444 | Compound was evaluated for growth inhibition against MCF-7 cells using cellular assay | 1998 | Bioorganic & medicinal chemistry letters, May-05, Volume: 8, Issue:9 | The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins. |
| AID1381554 | Cytotoxicity against human PANC1 cells after 48 hrs by XTT assay | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | New somatostatin-drug conjugates for effective targeting pancreatic cancer. |
| AID1381555 | Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | New somatostatin-drug conjugates for effective targeting pancreatic cancer. |
| AID57058 | Inhibitory activity against human DNA Topoisomerase-2, activity is expressed as relative DNA cleavage compared to Azatoxin by densitometric analysis | 1996 | Journal of medicinal chemistry, May-24, Volume: 39, Issue:11 | Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain. |
| AID156331 | Compound was evaluated for growth inhibition against PC-3 cells using cellular assay | 1998 | Bioorganic & medicinal chemistry letters, May-05, Volume: 8, Issue:9 | The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins. |
| AID218985 | Compound was evaluated for inhibition of tubulin polymerization in bovine brain tubulin | 1998 | Bioorganic & medicinal chemistry letters, May-05, Volume: 8, Issue:9 | The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins. |
| AID1381553 | Cytotoxicity against human Capan1 cells after 72 hrs by XTT assay | 2018 | Bioorganic & medicinal chemistry, 07-30, Volume: 26, Issue:13 | New somatostatin-drug conjugates for effective targeting pancreatic cancer. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.36) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||