Compounds > demethyloxyaaptamine
Page last updated: 2024-11-12

demethyloxyaaptamine

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Description

demethyloxyaaptamine: from Hymeniacidon sp.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10036084
CHEMBL ID235395
SCHEMBL ID8013716
MeSH IDM0465822

Synonyms (9)

Synonym
demethyloxyaaptamine
demthyloxyaaptamine
CHEMBL235395
8-METHOXY-9H-BENZO[DE][1,6]NAPHTHYRIDIN-9-ONE
SCHEMBL8013716
demethyloxy-aaptamine
bdbm50476979
9h-benzo[de][1,6]naphthyridin-9-one, 8-methoxy-
demethyl(oxy)aaptamine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID381212Cytotoxicity against human A549 cells after 6 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
AID400604Antineoplastic activity against human OVCAR-3 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400606Antineoplastic activity against human A498 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400603Antineoplastic activity against mouse P388 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID397143Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID400878Antineoplastic activity against human KM20L2 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID397145Cytotoxicity against mouse EL-4.IL-2 cells after 3 to 4 days by Trypan blue exclusion test1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID300936Inhibition of SrtA2007Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.
AID397142Cytotoxicity against human A549 cells after 48 hrs by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID381211Cytotoxicity against human KB16 cells after 3 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
AID400879Antineoplastic activity against human SK-MEL-5 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID400877Antineoplastic activity against human NCI-H460 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID397144Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID381210Cytotoxicity against mouse P388 cells after 3 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
AID400605Antineoplastic activity against human SF295 cells2004Journal of natural products, Mar, Volume: 67, Issue:3
Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1.
AID397147Induction of PKC-mediated mouse EL-4.IL-2 cells adherence by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID300937Antimicrobial activity against Staphylococcus aureus Newman2007Bioorganic & medicinal chemistry letters, Oct-01, Volume: 17, Issue:19
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.
AID381213Cytotoxicity against human HT-29 cells after 6 days by MTT assay1999Journal of natural products, Sep, Volume: 62, Issue:9
Structures and cytotoxicity relationship of isoaaptamine and aaptamine derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.58

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.58 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.58)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
Berberine chloride (TN)
[no description available]		2.0310organic molecular entity
phosphoric acid, trisodium salt
[no description available]		2.0210sodium phosphate
meridine
meridine: polycyclic alkaloid derived from the marine sponge Corticium sp; structure given in first source		1.9810
puupehenone
[no description available]		1.9810
aaptamine
aaptamine: natural product from sea sponge Aaptos aaptos; structure given in first source; RN from CA Index Guide 1984		2.9540
22-epi-hippuristanol
[no description available]		1.9810
isoaaptamine
isoaaptamine: structure in first source		2.9540
latrunculin a
latrunculin A: 16-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica; see also latrunculin B; structure given in first source. latrunculin A : A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.		1.9810cyclic hemiketal;
macrolide;
oxabicycloalkane;
thiazolidinone		actin polymerisation inhibitor;
metabolite;
toxin
manzamine a
manzamine A: RN given refers to (1R-(1R*,9Z,13S*,13aR*,20aR*,21aR*)-isomer; RN for cpd without isomeric designation not avail 12/92. manzamine A : An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).		1.9810alkaloid;
beta-carbolines;
isoquinolines		animal metabolite;
anti-HSV-1 agent;
antimalarial;
antineoplastic agent;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
marine metabolite
discorhabdin p
discorhabdin P: sulfur-containing pyrroloiminoquinone alkaloid (or benzothiazepine); an enzyme inhibitor from a deep-water caribbean sponge of the Genus batzella; structure in first source		1.9810
manzamine b
manzamine B: from an Indonesian Acanthostrongylophora sponge with activity against infectious, tropical parasitic, and Alzheimer's diseases; structure in first source		1.9810
(1S,3aR,4S,6S,6aS,9aS,9bS)-9a-isocyano-6-(2-isocyano-2-methylpropyl)-1,4-dimethyl-7-methylidene-2,3,3a,4,5,6,6a,8,9,9b-decahydro-1H-phenalene
[no description available]		1.9810diterpenoidmetabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.420
Breast Cancer
[description not available]		02.1710
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1710