2,2'-biimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,2'-Biimidazole is a heterocyclic compound with two imidazole rings connected at the 2 and 2' positions. It is a versatile building block for the synthesis of various heterocyclic compounds with potential applications in diverse fields. Synthesis of 2,2'-biimidazole typically involves condensation reactions of imidazole derivatives. Research on 2,2'-biimidazole has focused on its applications in coordination chemistry, as it forms stable complexes with metal ions. These complexes exhibit interesting properties, including luminescence and catalytic activity. Additionally, 2,2'-biimidazole derivatives have shown potential in medicinal chemistry as antimicrobial agents, anticancer drugs, and inhibitors of enzymes. The study of 2,2'-biimidazole is driven by its unique structure and its ability to coordinate with metal ions, leading to a wide range of potential applications in different fields.'

2,2'-biimidazole: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	101463
CHEMBL ID	333830
SCHEMBL ID	81650
MeSH ID	M0180204

Synonyms (32)

Synonym
nsc522950
492-98-8
2,2'-biimidazole
nsc-522950
1h,1'h-[2,2']biimidazolyl
CHEMBL333830
2-(1h-imidazol-2-yl)-1h-imidazole
AKOS005609260
STK792841
1h,1'h-2,2'-biimidazole
wez56mm6ec ,
unii-wez56mm6ec
nsc 522950
h2biim
einecs 207-768-8
2,2'-bi-1h-imidazole
FT-0676583
1'h-2,2'-biimidazole
AZUHIVLOSAPWDM-UHFFFAOYSA-N
2,2'bi-1h-imidazole
SCHEMBL81650
bisimidazole
B2487 ,
mfcd00047014
DTXSID30197715
CS-W021324
DS-4584
SY041535
2,2 inverted exclamation mark -biimidazole
YSWG105
n-(2,6-diethylphenylcarbamoylmethyl)iminodiaceticanhydride
A871823

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID173985	25% increase in left ventricular contractility (dP/dtmax) on iv administration in anesthetized rat	1990	Journal of medicinal chemistry, Jan, Volume: 33, Issue:1	Synthesis and cardiotonic activity of novel biimidazoles.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (16.67)	18.2507
2000's	4 (33.33)	29.6817
2010's	6 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.47 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.73 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.47)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	2.06	1	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	2.05	1	imidazole
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.48	2	bipyridine	chelator; ferroptosis inhibitor
amrinone Amrinone: A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.. amrinone : A 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.	1.97	1	bipyridines	EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
milrinone [no description available]	1.97	1	bipyridines; nitrile; pyridone	cardiotonic drug; EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor; platelet aggregation inhibitor; vasodilator agent
sulfosalicylic acid 5-sulfosalicylic acid : An arenesulfonic acid that is benzoic acid substituted by a hydroxy at position C-2 and a sulfo group at C-5.	2.05	1	arenesulfonic acid; benzoic acids; phenols	metabolite
iridium Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.	2.04	1	cobalt group element atom; platinum group metal atom
molybdenum Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.	2.03	1	chromium group element atom	micronutrient
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.99	4	iron group element atom; platinum group metal atom
enoximone Enoximone: A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.	1.97	1	aromatic ketone
singlet oxygen Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.	7.08	1	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient
bismuth Bismuth: A metallic element that has the atomic symbol Bi, and atomic number 83. Its principal isotope is Bismuth 209.	2.15	1	metal atom; pnictogen
salicylates Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.	2.05	1	monohydroxybenzoate	plant metabolite
quazinone [no description available]	1.97	1

Condition	Indicated	Relationship Strength	Studies	Trials
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	0	1.97	1	0
Experimental Leukemia [description not available]	0	1.97	1	0

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