Target type: molecularfunction
Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. [PMID:11461919, PMID:15364545, PMID:8486631, PMID:9675028, RHEA:22176]
Leukotriene-B4 20-monooxygenase activity is an enzymatic function that catalyzes the oxidation of leukotriene B4 (LTB4), a potent lipid mediator involved in inflammation. LTB4 is a product of the 5-lipoxygenase pathway, a major route for the biosynthesis of inflammatory mediators from arachidonic acid. The 20-monooxygenase enzyme incorporates one atom of oxygen from molecular oxygen (O2) into LTB4 at the 20-position, resulting in the formation of 20-hydroxy-LTB4. This reaction is a crucial step in the inactivation and degradation of LTB4, as 20-hydroxy-LTB4 has significantly reduced biological activity compared to LTB4. The enzymatic activity of leukotriene-B4 20-monooxygenase is important for regulating the duration and intensity of inflammatory responses. By catalyzing the conversion of LTB4 to its inactive metabolite, the enzyme contributes to the resolution of inflammation and prevents excessive inflammatory damage.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Cytochrome P450 4F3 | A cytochrome P450 4F3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08477] | Homo sapiens (human) |
| Cytochrome P450 4F2 | A cytochrome P450 4F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78329] | Homo sapiens (human) |
| Cytochrome P450 4F3 | A cytochrome P450 4F3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08477] | Homo sapiens (human) |
| Cytochrome P450 4A11 | A cytochrome P450 4A11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02928] | Homo sapiens (human) |
| Cytochrome P450 4F2 | A cytochrome P450 4F2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78329] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 17-octadecynoic acid | octadec-17-ynoic acid : An acetylenic fatty acid that is octadecanoi acid (stearic acid) which has been doubly dehydrogenated at positions 17 and 18 to give the corresponding alkynoic acid. | acetylenic fatty acid; long-chain fatty acid; monounsaturated fatty acid; terminal acetylenic compound | EC 1.14.14.94 (leukotriene-B4 20-monooxygenase) inhibitor; EC 1.14.15.3 (alkane 1-monooxygenase) inhibitor; P450 inhibitor |
| ketoconazole | 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively. | dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine | |
| tranylcypromine | (1R,2S)-tranylcypromine : A 2-phenylcyclopropan-1-amine that is the (1R,2S)-enantiomer of tranylcypromine. tranylcypromine : A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine). Tranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) | 2-phenylcyclopropan-1-amine | |
| proadifen hydrochloride | |||
| pirlindole | pirlindole: RN given refers to parent cpd; synonym pyrazidol refers to mono-HCl; structure in Negwer, 5th ed, #2812 | carbazoles | |
| 17-dihydroexemestane | |||
| kaf156 | ganaplacide: antimalarial |