Page last updated: 2024-12-10
1,4-benzenedithiol
Description
## 1,4-Benzenedithiol: A Versatile Building Block for Research
**1,4-Benzenedithiol** (also known as **1,4-dithiobenzene** or **p-benzenedithiol**) is an organic compound with the chemical formula C6H4(SH)2. It's essentially a benzene ring with two thiol groups (-SH) attached in a **para** (opposite) configuration.
**Why is it important for research?**
1,4-Benzenedithiol plays a crucial role in various research areas due to its unique properties:
* **Versatile Reactivity:** The thiol groups are highly reactive and can participate in a wide range of chemical reactions, including:
* **Nucleophilic attack:** The sulfur atom can act as a nucleophile, forming bonds with electrophilic centers.
* **Metal complexation:** The thiol groups can coordinate to various metal ions, forming complexes with diverse applications.
* **Disulfide bond formation:** Two thiol groups can react to form disulfide bonds, which play essential roles in biological systems.
* **Self-Assembly:** 1,4-Benzenedithiol has a tendency to self-assemble into various structures, such as nanowires and supramolecular complexes. This property is valuable in the development of new materials with tailored properties.
* **Applications in Materials Science:** 1,4-Benzenedithiol is employed in:
* **Organic electronics:** Its electron-donating properties and ability to form conductive polymers make it useful in the development of organic solar cells, transistors, and light-emitting diodes.
* **Nanotechnology:** 1,4-Benzenedithiol is used as a molecular building block for the fabrication of nanowires, nanoscale devices, and self-assembled monolayers (SAMs).
* **Biological Research:**
* **Enzyme inhibitors:** 1,4-Benzenedithiol and its derivatives can act as inhibitors for enzymes containing cysteine residues.
* **Bioconjugation:** It can be used to label biomolecules, facilitating their analysis and study.
**Research Areas:**
1,4-Benzenedithiol is crucial in various research areas, including:
* **Organic Chemistry:** Developing new synthetic methodologies and exploring the reactivity of thiol groups.
* **Materials Science:** Designing new organic materials with specific properties for electronics and nanotechnology applications.
* **Biochemistry and Pharmacology:** Developing new drugs and studying enzyme activity.
* **Surface Chemistry:** Studying self-assembly and the formation of SAMs on different surfaces.
In summary, 1,4-benzenedithiol is a versatile building block with a wide range of applications in research, thanks to its reactivity, self-assembly properties, and importance in various scientific fields. Its unique properties make it a valuable tool for developing new materials, understanding biological processes, and advancing diverse areas of science.
1,4-benzenedithiol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
PubMed CID | 4691729 |
SCHEMBL ID | 64710 |
MeSH ID | M0505696 |
Synonyms (25)
Synonym |
1,4-benzenedithiol |
624-39-5 |
B1505 |
dithiohydroquinone |
A8632 |
benzene-1,4-dithiol |
AKOS005207204 |
FT-0606769 |
SCHEMBL64710 |
1,4-benzene dithiol |
4-mercaptothiophenol |
WYLQRHZSKIDFEP-UHFFFAOYSA-N |
DTXSID80405615 |
CS-0100444 |
c6h6s2 |
benzene-1,4-dithiol, 99% (gc) |
mfcd00142541 |
BBL103921 |
STL557731 |
calciumundecylenate |
AMY22355 |
GEO-04155 |
MS-20722 |
T71138 |
1,4-benzenendithiol |
Research
Studies (18)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (22.22) | 29.6817 |
2010's | 10 (55.56) | 24.3611 |
2020's | 4 (22.22) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 28.49
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 28.49 (24.57) | Research Supply Index | 2.94 (2.92) | Research Growth Index | 4.94 (4.65) | Search Engine Demand Index | 32.99 (26.88) | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 18 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |