Page last updated: 2024-12-06

1,4-benzenedimethanethiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,4-benzenedimethanethiol is a bit of a misnomer, as it suggests a compound with two thiol groups directly attached to the benzene ring. However, the correct structure for this compound, also known as **1,4-bis(mercaptomethyl)benzene**, looks like this:

```
SH
|
S-CH2-Ph-CH2-S
|
SH
```

Here, **Ph** represents the benzene ring.

This molecule is important in research because it offers unique functionalities and can be utilized in various applications:

* **Building Block for Organic Synthesis:** The two thiol groups provide reactive sites for further chemical modifications. This makes 1,4-bis(mercaptomethyl)benzene a versatile building block for synthesizing diverse organic compounds with potential uses in pharmaceuticals, materials science, and other fields.
* **Metal Complexation:** The thiol groups have a strong affinity for various metal ions. This property allows 1,4-bis(mercaptomethyl)benzene to act as a chelating agent, forming stable metal complexes. This is important for applications in areas like:
* **Catalysis:** Metal complexes with 1,4-bis(mercaptomethyl)benzene can act as catalysts in various chemical reactions.
* **Sensors:** The change in color or other properties of the metal complex upon binding to specific ions can be exploited in the development of sensors.
* **Material Science:** 1,4-bis(mercaptomethyl)benzene can be used to create self-assembled monolayers (SAMs) on metal surfaces. These SAMs can modify the surface properties of metals, impacting their wettability, adhesion, and other properties, finding applications in fields like:
* **Corrosion prevention:** SAMs can form a protective layer on metal surfaces, preventing corrosion.
* **Biomaterial development:** SAMs can be modified to create biocompatible surfaces for implants or other biomedical applications.

**Note:** The importance of 1,4-bis(mercaptomethyl)benzene in research is tied to its specific properties and the potential applications it offers in various fields.

Cross-References

ID SourceID
PubMed CID66043
SCHEMBL ID127369
MeSH IDM0500989

Synonyms (42)

Synonym
AC-16428
NCIOPEN2_000587
1,4-benzene dimethanethiol
p-xylylenedithiol
1,4-bis(mercaptomethyl)benzene
105-09-9
1,4-benzenedimethanethiol
1,4-benzenebis(methanethiol)
p-xylene-.alpha.,.alpha.'-dithiol
.alpha.,.alpha.'-p-xylenedithiol
nsc72094
nsc-72094
1,4-benzenedimethanethiol, 98%
alpha,alpha'-dimercapto-p-xylene
b1521 ,
[4-(sulfanylmethyl)phenyl]methanethiol
A801150
nsc 72094
k48ubz9imd ,
p-xylene-alpha,alpha'-dithiol
alpha,alpha'-p-xylenedithiol
unii-k48ubz9imd
einecs 203-269-4
FT-0606761
doi:10.14272/iypnrtqaoxlcqw-uhfffaoysa-n
10.14272/IYPNRTQAOXLCQW-UHFFFAOYSA-N
AKOS015897641
SCHEMBL127369
J-503964
DTXSID1059313
4-(sulfanylmethyl)benzyl hydrosulfide #
mfcd00004872
AS-58454
.alpha.,.alpha.'-dimercapto-p-xylene
1,4-xylylenedithiol
1,4-bis(mercaptomethyl)-benzene
Q63408976
3-oxo-3-(3-trifluoromethylphenyl)propionicacidethylester
1,4-phenylenedimethanethiol
T70041
doi:10.14272/iypnrtqaoxlcqw-uhfffaoysa-n.1
10.14272/IYPNRTQAOXLCQW-UHFFFAOYSA-N.1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.94 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]