1-hydroxymethylmidazolam and ketoconazole
1-hydroxymethylmidazolam has been researched along with ketoconazole in 9 studies
Compound Research Comparison
| Studies (1-hydroxymethylmidazolam) | Trials (1-hydroxymethylmidazolam) | Recent Studies (post-2010) (1-hydroxymethylmidazolam) | Studies (ketoconazole) | Trials (ketoconazole) | Recent Studies (post-2010) (ketoconazole) |
|---|---|---|---|---|---|
| 163 | 46 | 49 | 6,202 | 706 | 1,269 |
Protein Interaction Comparison
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ring, BJ; Wrighton, SA | 1 |
| Bayliss, MK; Eddershaw, PJ; Herriott, D; Manchee, GR; Park, GR; Ranshaw, LE; Tarbit, MH | 1 |
| Akiyama, TE; Cheung, C; Elizondo, G; Feigenbaum, L; Gonzalez, FJ; Granvil, CP; Krausz, KW; Yu, AM | 1 |
| Aubert, AC; Baumann, P; Bleiber, G; Buclin, T; Cucchia, G; Eap, CB; Golay, KP; Hustert, E; Kerb, R; Telenti, A; Zullino, D | 1 |
| Cao, L; Li, G; Qiu, J; Ren, XH; Si, LQ; Yao, J | 1 |
| Foti, RS; Pearson, JT; Rock, DA | 1 |
| Li, WL; Su, MW; Xin, HW | 1 |
| Burhenne, J; Fuchs, I; Haefeli, WE; Hafner-Blumenstiel, V; Markert, C; Mikus, G; Weiss, J | 1 |
| He, F; Huang, S; Liu, M; Xia, C; Xiong, Y; Zeng, C; Zhang, H; Zhang, W | 1 |
Trials
2 trial(s) available for 1-hydroxymethylmidazolam and ketoconazole
| Article | Year |
|---|---|
Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating | 2004 |
Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity.
Topics: Adult; Area Under Curve; Biotransformation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Germany; Humans; Hydroxylation; Hypericum; Ketoconazole; Male; Metabolic Clearance Rate; Midazolam; Middle Aged; Plant Extracts; Plants, Medicinal; Pregnane X Receptor; Receptors, Steroid; Substrate Specificity; Transcription, Genetic; Young Adult | 2013 |
Other Studies
7 other study(ies) available for 1-hydroxymethylmidazolam and ketoconazole
| Article | Year |
|---|---|
Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine.
Topics: Chromatography, High Pressure Liquid; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Nizatidine | 1994 |
The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A.
Topics: Adrenergic beta-Agonists; Albuterol; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Humans; Isoenzymes; Ketoconazole; Microsomes, Liver; Midazolam; Molecular Structure; Oxidation-Reduction; Quinidine; Recombinant Proteins; Salmeterol Xinafoate; Sulfaphenazole; Theophylline | 1996 |
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Blotting, Southern; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; In Vitro Techniques; Intestine, Small; Ketoconazole; Male; Mice; Mice, Transgenic; Microsomes; Midazolam; Polymerase Chain Reaction; Rifampin; Time Factors | 2003 |
[Effect of polyoxyl ether analogous surfactants on the activity of cytochromes P450 3A in rats in vivo].
Topics: Animals; Area Under Curve; Biological Availability; Biotransformation; Cytochrome P-450 CYP3A; Ketoconazole; Male; Midazolam; Octoxynol; Polyethylene Glycols; Random Allocation; Rats; Rats, Sprague-Dawley; Surface-Active Agents | 2008 |
The combination of chemical and antibody inhibitors for superior P450 3A inhibition in reaction phenotyping studies.
Topics: Antibodies, Monoclonal; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxytestosterones; Ketoconazole; Microsomes, Liver; Midazolam; Protein Isoforms; Testosterone | 2008 |
Inhibitory effects of continuous ingestion of Schisandrin A on CYP3A in the rat.
Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Ketoconazole; Lignans; Male; Microsomes, Liver; Midazolam; Polycyclic Compounds; Rats; Rats, Sprague-Dawley | 2012 |
Mechanism of Action of Panaxytriol on Midazolam 1'-Hydroxylation and 4-Hydroxylation Mediated by CYP3A in Liver Microsomes and Rat Primary Hepatocytes.
Topics: Animals; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Enediynes; Fatty Alcohols; Hepatocytes; Humans; Hydroxylation; Ketoconazole; Microsomes, Liver; Midazolam; Rats; RNA, Messenger | 2015 |