Page last updated: 2024-12-07

nsc 327729

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

S-2-(3-methylaminopropylamino)ethylphosphorothioic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100598
CHEMBL ID159688
SCHEMBL ID1487674
MeSH IDM0141424

Synonyms (21)

Synonym
20751-90-0
nsc-327729
nsc327729
phosphorothioic acid, s-[2-[[3-(methylamino)propyl]amino]ethyl] ester
phosphorothioic acid, s-(2-((3-(methylamino)propyl)amino)ethyl) ester
2-((3-(methylamino)propyl)amino)ethanethiol dihydrogen phosphate (ester)
brn 5508739
ethanethiol, 2-((3-(methylamino)propyl)amino)-, dihydrogen phosphate (ester)
wr 3689
2-[3-(methylamino)propylamino]ethylsulfanylphosphonic acid
CHEMBL159688
wr-3689
phosphonol
n2ew24ax4g ,
nsc 327729
s-2-(3-methylaminopropylamino)ethylphosphorothioic acid
unii-n2ew24ax4g
SCHEMBL1487674
DTXSID70174828
ethanethiol, 2-((3-(methylamino)propyl)amino)-, 1-(dihydrogen phosphate)
2-(3-(methylamino)propylamino)ethylsulfanylphosphonic acid

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Toxicity assessments in the mouse yielded a LD50 of 297 mg/kg and in the rat 389 mg/kg."( Toxicity, biodistribution and radioprotective capacity of L-homocysteine thiolactone in CNS tissues and tumors in rodents: comparison with prior results with phosphorothioates.
Ali-Osman, F; Chin, L; Dwyer-Hansen, L; Grunbaum, Z; Krohn, KA; Livesey, J; Nelson, N; Rasey, JS; Spence, AM; Stein, D, 1995
)
0.29
" There is also evidence that aminothiols are toxic to the germinal cell layer of the seminiferous tubules when given to sham-irradiated mice."( Comparative intestinal and testes toxicity of four aminothiols in irradiated and nonirradiated mice.
Eckstein, JM; Egan, JE; Heman-Ackah, LM; Jackson, WE; Kendrick, JM; Steel-Goodwin, L,
)
0.13

Compound-Compound Interactions

ExcerptReferenceRelevance
" Therapeutic glucan treatment administered in combination with preirradiation WR-2721 or WR-3689 treatment synergistically increases both hematopoietic reconstitution and survival."( Radioprotection by polysaccharides alone and in combination with aminothiols.
Brook, I; D'Alesandro, MM; MacVittie, TJ; Patchen, ML; Solberg, BD, 1992
)
0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (45.45)18.7374
1990's12 (54.55)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.35%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (95.65%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]