wr-77913 and Disease-Models--Animal

wr-77913 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for wr-77913 and Disease-Models--Animal

Article	Year
Phase separation inhibitors and lens transparency. Optometry and vision science : official publication of the American Academy of Optometry, 1993, Volume: 70, Issue:11 A phase separation inhibitor, WR77913 [S-3(amino-2-hydroxypropyl) phosphorothioate], was tested for its effects on lens opacification in the radiation (RAD), selenite (SEL), galactose (GAL), streptozotocin (STZ), and Royal College of Surgeons (RCS) models for cataract. A single i.p. injection of WR77913, approximately 15 min before induction of cataract formation by RAD, SEL, STZ delayed or inhibited opacification. Repeated administration was necessary to delay or inhibit opacification in the GAL or RCS models for cataracts. The results suggest that phase separation inhibitors such as WR77913 have the potential to delay or inhibit lens opacification resulting from a variety of physiological or biochemical mechanisms. Topics: Amifostine; Animals; Cataract; Disease Models, Animal; Female; Galactose; Lens, Crystalline; Male; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Sodium Selenite; Streptozocin	1993

Article

Year

Phase separation inhibitors and lens transparency.

Optometry and vision science : official publication of the American Academy of Optometry, 1993, Volume: 70, Issue:11

A phase separation inhibitor, WR77913 [S-3(amino-2-hydroxypropyl) phosphorothioate], was tested for its effects on lens opacification in the radiation (RAD), selenite (SEL), galactose (GAL), streptozotocin (STZ), and Royal College of Surgeons (RCS) models for cataract. A single i.p. injection of WR77913, approximately 15 min before induction of cataract formation by RAD, SEL, STZ delayed or inhibited opacification. Repeated administration was necessary to delay or inhibit opacification in the GAL or RCS models for cataracts. The results suggest that phase separation inhibitors such as WR77913 have the potential to delay or inhibit lens opacification resulting from a variety of physiological or biochemical mechanisms.

Topics: Amifostine; Animals; Cataract; Disease Models, Animal; Female; Galactose; Lens, Crystalline; Male; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Sodium Selenite; Streptozocin

1993