Compounds > tropacine
Page last updated: 2024-12-07

tropacine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tropacine: RN given refers to (endo)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID120731
CHEMBL ID3349189
SCHEMBL ID250617
MeSH IDM0044827

Synonyms (31)

Synonym
3-alpha-diphenylacetoxytropine
(diphenylacetyl)atropine
tropacin
na 184
3-alpha-tropanyl diphenylacetate
benzeneacetic acid, alpha-phenyl-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-
acetic acid, diphenyl-, 3-alpha-tropanyl ester
diphenylacetic acid 3-alpha-tropanyl ester
tropacine
piperidol 3-alpha-tropanyl ester
1-alpha-h,5-alpha-h-tropan-3-alpha-ol, diphenylacetate
tropanyl alpha-phenylbenzeneacetate
endo-alpha-phenylbenzeneacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester
tropine diphenylacetate
AKOS005267195
6878-98-4
2phn0yp48u ,
unii-2phn0yp48u
SCHEMBL250617
1.alpha.h,5.alpha.h-tropan-3.alpha.-ol, diphenylacetate (ester)
benzeneacetic acid, .alpha.-phenyl-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-
na-184
tropacine [mi]
3.alpha.-tropanyl diphenylacetate
tropacine [who-dd]
acetic acid, diphenyl-, 3.alpha.-tropanyl ester
CHEMBL3349189
8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2,2-diphenylacetate
[(1s,5r)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2,2-diphenylacetate
Q27255412
PD163228
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1099222Insecticidal activity against Bombyx mori Shunrei x Shogetu fourth-instar larva assessed as effect on larval growth at 160 ug/larvae upon topial application1998Bioscience, biotechnology, and biochemistry, Oct, Volume: 62, Issue:10
Effect of tropine derivatives, antimuscarinic agents, on the growth of Bombyx mori larvae.
AID1099221Insecticidal activity against Bombyx mori Shunrei x Shogetu fourth-instar larva assessed as effect on larval molting at 160 ug/larvae upon topial application1998Bioscience, biotechnology, and biochemistry, Oct, Volume: 62, Issue:10
Effect of tropine derivatives, antimuscarinic agents, on the growth of Bombyx mori larvae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (83.33)18.7374
1990's1 (8.33)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.08

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.08 (24.57)
Research Supply Index3.26 (2.92)
Research Growth Index4.16 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.08)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (4.17%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
trihexyphenidyl
Trihexyphenidyl: One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.		1.9510amine
trichlorfon
Trichlorfon: An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed). trichlorfon : A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.		1.9610organic phosphonate;
organochlorine compound;
phosphonic ester		agrochemical;
anthelminthic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
benactyzine
Benactyzine: A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.		2.3520diarylmethane
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.8440benzenes;
phenyl acetates
3,3-diphenylpropanoate
[no description available]		1.9910
nicotine
(S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.		1.93103-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
atropine
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.		2.3620
scopolamine hydrobromide
[no description available]		1.9310
cardiovascular agents
Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.		2.6230
trimedoxime bromide
Trimedoxime: Cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Basal Ganglia Diseases
Diseases of the BASAL GANGLIA including the PUTAMEN; GLOBUS PALLIDUS; claustrum; AMYGDALA; and CAUDATE NUCLEUS. DYSKINESIAS (most notably involuntary movements and alterations of the rate of movement) represent the primary clinical manifestations of these disorders. Common etiologies include CEREBROVASCULAR DISORDERS; NEURODEGENERATIVE DISEASES; and CRANIOCEREBRAL TRAUMA.		02.3320
Disease
A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.		02.3320
Gastroduodenal Ulcer
[description not available]		01.9310
Peptic Ulcer
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		01.9310
Dyskinesia Syndromes
[description not available]		01.9310
Movement Disorders
Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.		01.9310
Nervous System Disorders
[description not available]		02.6230
Nervous System Diseases
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.		02.6230
Asthma, Bronchial
[description not available]		01.9310
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		06.9310
Urination Disorders
Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.		03.3911
Urinary Incontinence
Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types of incontinence include URINARY URGE INCONTINENCE and URINARY STRESS INCONTINENCE.		03.3911