tibenelast profile

Tibonelast is a synthetic compound with a complex chemical structure that was developed as a potential therapeutic agent for various medical conditions. Research has focused on its potential effects on inflammation, pain, and certain types of cancer. Its unique chemical properties have made it a subject of interest in drug development, and ongoing studies are aimed at further understanding its mechanisms of action and potential therapeutic applications. The synthesis of tibenelast involves a multi-step process, and its exact mechanism of action is still being elucidated. However, preliminary studies suggest that it may exert its effects by modulating specific cellular pathways involved in inflammation and pain signaling. The potential for tibenelast to be used as a therapeutic agent is being investigated in clinical trials. However, further research is required to assess its safety, efficacy, and optimal dosage for various medical conditions.'

tibenelast: RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	59913
CHEMBL ID	2111055
SCHEMBL ID	449748
MeSH ID	M0175931

Synonym
benzo(b)thiophene-2-carboxylic acid, 5,6-diethoxy-
tibenelastum [latin]
tibenelast [inn]
h051v8lj93 ,
97852-72-7
tibenelastum
tibenelast
5,6-diethoxybenzo(b)thiophene-2-carboxylic acid
unii-h051v8lj93
tibenclast
nsc108930
nsc-108930
5,6-diethoxy-1-benzothiophene-2-carboxylic acid
SCHEMBL449748
PDUXMHXBBXXJFQ-UHFFFAOYSA-N
5,6-diethoxybenzothiophene-2-carboxylic acid
CHEMBL2111055
DTXSID10243289
AKOS030587206
nsc 108930
Q27279397
5,6-diethoxybenzo[b]thiophene-2-carboxylic acid

Excerpt	Relevance	Reference
" Heart rates in response to isoproterenol dosing were fitted by linear regression, and horizontal shifts in the regression lines were examined between the three treatments."	( Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Bowsher, RR; Cerimele, BJ; McNay, JL; Rowe, H; Schwertschlag, US, 1993)	0.69

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (20.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
theophylline [no description available]	8.77	2	1	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent
isoproterenol Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.	8.37	1	1	catechols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; sympathomimetic agent
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	4.46	5	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
aminophylline Aminophylline: A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.. aminophylline : A mixture comprising of theophylline and ethylenediamine in a 2:1 ratio.	1.97	1	0	mixture	bronchodilator agent; cardiotonic drug
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	1.97	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite

Condition	Relationship Strength	Studies
Asthma, Bronchial [description not available]	2.38	2
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.38	2
Anaphylactic Reaction [description not available]	1.97	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.97	1
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	1.97	1

tibenelast

Description

Cross-References

Synonyms (22)

Research Excerpts

Dosage Studied

Research

Studies (5)

Study Types