Page last updated: 2024-08-24

tibenelast and thiophenes

tibenelast has been researched along with thiophenes in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bury, T; Corhay, JL; Louis, R; Radermecker, M1
Bowling, N; Hayes, SJ; Ho, PP; Panetta, JA; Pollock, D; Towner, RD; Wang, LY; Wyss, V1
Peyton, AL; Ziege, EA1
Bertsch, B; Esterman, M; Ho, PP; Panetta, JA1
Bowsher, RR; Cerimele, BJ; McNay, JL; Rowe, H; Schwertschlag, US1

Trials

1 trial(s) available for tibenelast and thiophenes

ArticleYear
Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels.
    Pharmacology, 1993, Volume: 46, Issue:3

    Topics: Adult; Blood Pressure; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Humans; Isoproterenol; Male; Middle Aged; Norepinephrine; Phosphodiesterase Inhibitors; Regression Analysis; Theophylline; Thiophenes

1993

Other Studies

4 other study(ies) available for tibenelast and thiophenes

ArticleYear
LY 186655, a phosphodiesterase inhibitor, inhibits histamine release from human basophils, lung and skin fragments.
    International journal of immunopharmacology, 1992, Volume: 14, Issue:2

    Topics: Adult; Basophils; Bronchodilator Agents; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Lung; Skin; Theophylline; Thiophenes

1992
Cardiovascular effect and stimulus-dependent inhibition of superoxide generation from human neutrophils by tibenelast, 5,6-diethoxybenzo(b)thiophene-2-carboxylic acid, sodium salt (LY186655).
    Biochemical pharmacology, 1990, Nov-01, Volume: 40, Issue:9

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bronchodilator Agents; Cats; Dogs; Guinea Pigs; Heart Rate; Humans; In Vitro Techniques; Myocardial Contraction; Neutrophils; Phosphodiesterase Inhibitors; Stimulation, Chemical; Superoxides; Thiophenes

1990
Determination of a potential antiasthmatic compound, tibenelast, and its application to phase I clinical trials.
    Journal of chromatography, 1990, Aug-03, Volume: 529, Issue:2

    Topics: Asthma; Blood Proteins; Chromatography, High Pressure Liquid; Drug Evaluation; Humans; Indicators and Reagents; Male; Solutions; Thiophenes

1990
Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig.
    Life sciences, 1990, Volume: 46, Issue:13

    Topics: Administration, Oral; Airway Resistance; Aminophylline; Anaphylaxis; Animals; Asthma; Bronchodilator Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Epinephrine; Female; Guinea Pigs; Injections, Intravenous; Lung Compliance; Male; Molecular Structure; Thiophenes

1990