tibenelast has been researched along with thiophenes in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bury, T; Corhay, JL; Louis, R; Radermecker, M | 1 |
| Bowling, N; Hayes, SJ; Ho, PP; Panetta, JA; Pollock, D; Towner, RD; Wang, LY; Wyss, V | 1 |
| Peyton, AL; Ziege, EA | 1 |
| Bertsch, B; Esterman, M; Ho, PP; Panetta, JA | 1 |
| Bowsher, RR; Cerimele, BJ; McNay, JL; Rowe, H; Schwertschlag, US | 1 |
1 trial(s) available for tibenelast and thiophenes
| Article | Year |
|---|---|
Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels.
Topics: Adult; Blood Pressure; Cyclic AMP; Dose-Response Relationship, Drug; Heart Rate; Humans; Isoproterenol; Male; Middle Aged; Norepinephrine; Phosphodiesterase Inhibitors; Regression Analysis; Theophylline; Thiophenes | 1993 |
4 other study(ies) available for tibenelast and thiophenes
| Article | Year |
|---|---|
LY 186655, a phosphodiesterase inhibitor, inhibits histamine release from human basophils, lung and skin fragments.
Topics: Adult; Basophils; Bronchodilator Agents; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Lung; Skin; Theophylline; Thiophenes | 1992 |
Cardiovascular effect and stimulus-dependent inhibition of superoxide generation from human neutrophils by tibenelast, 5,6-diethoxybenzo(b)thiophene-2-carboxylic acid, sodium salt (LY186655).
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bronchodilator Agents; Cats; Dogs; Guinea Pigs; Heart Rate; Humans; In Vitro Techniques; Myocardial Contraction; Neutrophils; Phosphodiesterase Inhibitors; Stimulation, Chemical; Superoxides; Thiophenes | 1990 |
Determination of a potential antiasthmatic compound, tibenelast, and its application to phase I clinical trials.
Topics: Asthma; Blood Proteins; Chromatography, High Pressure Liquid; Drug Evaluation; Humans; Indicators and Reagents; Male; Solutions; Thiophenes | 1990 |
Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig.
Topics: Administration, Oral; Airway Resistance; Aminophylline; Anaphylaxis; Animals; Asthma; Bronchodilator Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Epinephrine; Female; Guinea Pigs; Injections, Intravenous; Lung Compliance; Male; Molecular Structure; Thiophenes | 1990 |