Compounds > subglutinol a
Page last updated: 2024-11-13

subglutinol a

Description

subglutinol A: an osteogenic agent isolated from Fusarium subglutinans; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID54693566
CHEMBL ID480487
SCHEMBL ID8824310
MeSH IDM0549480

Synonyms (3)

Synonym
subglutinol a
CHEMBL480487
SCHEMBL8824310

Research Excerpts

Overview

Subglutinol A is an immunosuppressive natural product isolated from Fusarium subglut inans. It is an endophytic fungus from the vine Tripterygium wilfordii.

ExcerptReferenceRelevance
"Subglutinol A (1) is an immunosuppressive natural product isolated from Fusarium subglutinans, an endophytic fungus from the vine Tripterygium wilfordii. "( Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
Hong, J; Kim, H; Li, QJ; Lin, R, 2014)		2.15
"Subglutinol A is an immunosuppressive α-pyrone diterpenoid isolated from Fusarium subglutinans that exhibits osteogenic activity. "( Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist.
Hong, J; Lee, Y; Lee, YH; Lim, W; Park, J, 2015)		3.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (45)

Assay IDTitleYearJournalArticle
AID1581483Immunosuppressive activity in OT2 mouse CD4-positive T cells derived OVA(323 to 339)-activated Th-differentiating media cultured Th1 cells assessed as reduction in pDBU/ionomycin-stimulated IFNgamma production treated last 2 days of 5 days differentiation2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1224295Induction of apoptosis in pMel-1 TCR transgenic C57BL/6 mouse gp100 (25 to 33)-activated CD8-positive T cells assessed as live undivided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 23.4%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224303Antiinflammatory activity in LLO118 TCR transgenic mouse IL-2-competent CD4-positive T cells assessed as inhibition of LLO (190 to 205)-induced IL-2 production at 1 nM for 2 days by flow cytometric analysis relative to control2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224311Induction of mitochondrial depolarization in LLO118 TCR transgenic mouse Th17 cells treated for 2 days by MitoTracker Orange CMTMRos staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224296Induction of apoptosis in pMel-1 TCR transgenic C57BL/6 mouse gp100 (25 to 33)-activated CD8-positive T cells assessed as dead undivided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 6.77%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1581488Immunosuppressive activity in OT2 mouse CD4-positive T cells derived OVA(323 to 339)-activated Th-differentiating media cultured Th1 cells assessed as reduction in pDBU/ionomycin-stimulated IFNgamma production at early stage by measuring INFgamma level at2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1581486Immunosuppressive activity in OT2 mouse CD4-positive T cells derived OVA(323 to 339)-activated Th-differentiating media cultured Th17 cells assessed as reduction in pDBU/ionomycin-stimulated 1L17A production by measuring IL17A level at 10 uM treated last 2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1581489Immunosuppressive activity in OT2 mouse CD4-positive T cells derived OVA(323 to 339)-activated Th-differentiating media cultured Th1 cells assessed as reduction in pDBU/ionomycin-stimulated IFNgamma production at early stage by measuring INFgamma level at2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1289306Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity.
AID1289308Antiproliferative activity against mouse B16F10 cells assessed as cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity.
AID1224307Antiinflammatory activity in LLO118 TCR transgenic mouse Th17 cells assessed as inhibition of IL-17 production at 10 to 100 nM for 2 days by flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224310Induction of mitochondrial depolarization in LLO118 TCR transgenic mouse Th1 cells treated for 2 days by MitoTracker Orange CMTMRos staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1581493Cytotoxicity against OT2 mouse CD4-positive T cells assessed as cell viability at 100 nM measured after 48 hrs by live/dead viability staining based flow cytometry (Rvb = 57.2%)2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1224294Induction of apoptosis in pMel-1 TCR transgenic C57BL/6 mouse gp100 (25 to 33)-activated CD8-positive T cells assessed as live divided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 55.2%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224299Induction of apoptosis in LLO118 TCR transgenic mouse LLO (190 to 205)-activated CD4-positive T cells assessed as live undivided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 41.6%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224304Antiinflammatory activity in LLO118 TCR transgenic mouse IL-2-competent CD4-positive T cells assessed as inhibition of LLO (190 to 205)-induced IL-2 production at 100 nM for 2 days by flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1581484Immunosuppressive activity in OT2 mouse CD4-positive T cells derived OVA(323 to 339)-activated Th-differentiating media cultured Th1 cells assessed as reduction in pDBU/ionomycin-stimulated IFNgamma production at late stage by measuring INFgamma level at 2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1224312Induction of mitochondrial depolarization in B6 mouse immature BMDC at 100 nM for 1 day by MitoTracker Orange CMTMRos staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1581485Immunosuppressive activity in OT2 mouse CD4-positive T cells derived OVA(323 to 339)-activated Th-differentiating media cultured Th1 cells assessed as reduction in pDBU/ionomycin-stimulated IFNgamma production at late stage by measuring INFgamma level at 2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1224298Induction of apoptosis in LLO118 TCR transgenic mouse LLO (190 to 205)-activated CD4-positive T cells assessed as live divided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 40.6%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224313Reduction in mitochondrial mass in B6 mouse immature BMDC at 100 nM for 1 day by MitoTracker Deep Red FM staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224297Induction of apoptosis in pMel-1 TCR transgenic C57BL/6 mouse gp100 (25 to 33)-activated CD8-positive T cells assessed as dead divided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 14.7%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224292Immunosuppressive activity in C57Bl/6 mouse lymphocytes assessed as inhibition of cell proliferation co-incubated with BALB/c mouse stimulator lymphocytes after 72 hrs by [3H]-thymidine incorporation assay2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1289304Antiproliferative activity against human U373 cells assessed as cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity.
AID1289307Antiproliferative activity against human SK-MEL-28 cells assessed as cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity.
AID1289303Antiproliferative activity against human Hs683 cells assessed as cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity.
AID1581492Cytotoxicity against OT2 mouse CD4-positive T cells assessed as cell viability at 10 uM measured after 48 hrs by live/dead viability staining based flow cytometry (Rvb = 57.2%)2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1224314Reduction in mitochondrial mass in LPS-matured B6 mouse BMDC at 100 nM for 1 day by MitoTracker Deep Red FM staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1581494Cytotoxicity against OT1 mouse CD8-positive T cells assessed as cell viability at 10 uM measured after 48 hrs by live/dead viability staining based flow cytometry (Rvb = 39.5%)2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID1224305Antiinflammatory activity in LLO118 TCR transgenic mouse Th1 cells assessed as inhibition of IFN-gamma production at 10 nM for 2 days by flow cytometric analysis (Rvb = 90%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224318Immunosuppressive activity in C57BL/6J mouse KLH-induced delayed-type hypersensitivity model assessed as alleviation of footpad swelling at 16 nmol administered on day 7 and 8 post-sensitization measured on day 92014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224293Immunosuppressive activity in mouse thymocytes assessed as inhibition of IL-1-induced cell proliferation for 72 hrs by [3H]thymidine incorporation assay2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1289305Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay2016Journal of natural products, Jan-22, Volume: 79, Issue:1
Higginsianins A and B, Two Diterpenoid α-Pyrones Produced by Colletotrichum higginsianum, with in Vitro Cytostatic Activity.
AID1581495Cytotoxicity against OT1 mouse CD8-positive T cells assessed as cell viability at 100 nM measured after 48 hrs by live/dead viability staining based flow cytometry (Rvb = 39.5%)2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
AID399578Immunosuppressive activity in thymocytes by thymocyte proliferation assay2004Journal of natural products, Feb, Volume: 67, Issue:2
Natural products from endophytic microorganisms.
AID1224319Immunosuppressive activity in C57BL/6J mouse KLH-induced delayed-type hypersensitivity model assessed as blockade of lymphocyte accumulation at 16 nmol administered on day 7 and 8 post-sensitization measured on day 92014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224308Reduction in mitochondrial mass in LLO118 TCR transgenic mouse Th1 cells at 50 to 100 nM for 2 days by MitoTracker Deep Red FM staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224309Reduction in mitochondrial mass in LLO118 TCR transgenic mouse Th17 cells at 50 to 100 nM for 2 days by MitoTracker Deep Red FM staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID399577Immunosuppressive activity in lymphocytes by mixed lymphocyte reaction assay2004Journal of natural products, Feb, Volume: 67, Issue:2
Natural products from endophytic microorganisms.
AID1224321Immunosuppressive activity in lymphocytes by MLR assay2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224301Induction of apoptosis in LLO118 TCR transgenic mouse LLO (190 to 205)-activated CD4-positive T cells assessed as dead divided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 3.04%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224300Induction of apoptosis in LLO118 TCR transgenic mouse LLO (190 to 205)-activated CD4-positive T cells assessed as dead undivided cells at 100 nM after 48 hrs by CFSE dilution/flow cytometric analysis (Rvb = 14.7%)2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224320Immunosuppressive activity in C57BL/6J mouse KLH-induced delayed-type hypersensitivity model assessed as amelioration of tissue injury at 16 nmol administered on day 7 and 8 post-sensitization measured on day 92014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1224315Induction of mitochondrial depolarization in LPS-matured B6 mouse BMDC at 100 nM for 1 day by MitoTracker Orange CMTMRos staining-based flow cytometric analysis2014ACS medicinal chemistry letters, May-08, Volume: 5, Issue:5
Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention.
AID1581487Immunosuppressive activity in OT2 mouse CD4-positive T cells derived OVA(323 to 339)-activated Th-differentiating media cultured Th17 cells assessed as reduction in pDBU/ionomycin-stimulated 1L17A production by measuring IL17A level at 100 nM treated last2020Journal of medicinal chemistry, 01-09, Volume: 63, Issue:1
Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's6 (60.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alkenes
[no description available]		3.4110
sesquiterpenes
[no description available]		3.4110
cyclosporine
ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF		2.110homodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
ascofuranone
ascofuranone: structure. ascofuranone : A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis.		3.4110dihydroxybenzaldehyde;
meroterpenoid;
monochlorobenzenes;
olefinic compound;
resorcinols;
sesquiterpenoid;
tetrahydrofuranone		angiogenesis inhibitor;
antilipemic drug;
antineoplastic agent;
antiprotozoal drug;
fungal metabolite
ascochlorin
ascochlorin: structure in first source. ascochlorin : A dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (1E,3E)-3-methyl-1-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]penta-1,3-dien-5-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by several fungi including Ascochyta viciae . It exhibits anticancer, antifungal and antiprotozoal activities.		3.4110cyclohexanones;
dihydroxybenzaldehyde;
meroterpenoid;
monochlorobenzenes;
olefinic compound;
resorcinols;
sesquiterpenoid		angiogenesis inhibitor;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
fungal metabolite
pyripyropene a
pyripyropene A: from Aspergillus fumigatus FO-1289; structure given in first source. pyripyropene A : A sesquiterpenoid that consists of (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diol in which the hydrogens of the 3- and 6-hydroxy functions are substituted by acetyl groups.		3.4110organic heterotetracyclic compound;
sesquiterpenoid		acyl-CoA:cholesterol acyltransferase 2 inhibitor;
metabolite
subglutinol b
subglutinol B: an osteogenic agent isolated from Fusarium subglutinans; structure in first source		4.5670
novofumigatonin
novofumigatonin: an orthoester meroterpenoid from Aspergillus novofumigatus; structure in first source		3.4110cyclic ketone;
meroterpenoid;
organic heteropolycyclic compound;
ortho ester
ConditionIndicatedRelationship StrengthStudiesTrials
MS (Multiple Sclerosis)
[description not available]		02.2510
Multiple Sclerosis
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)		02.2510
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