Page last updated: 2024-12-07
sk&f 102081
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
5-(2-dodecylphenyl)-4,6-dithianonanedioic acid: RN & structure in first source; leukotriene receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 126144 |
| CHEMBL ID | 15367 |
| SCHEMBL ID | 10482314 |
| MeSH ID | M0134623 |
Synonyms (13)
| Synonym |
|---|
| skf 102081 |
| skf-102081 |
| CHEMBL15367 , |
| 96964-39-5 |
| 3-[(2-carboxy-ethylsulfanyl)-(2-dodecyl-phenyl)-methylsulfanyl]-propionic acid (sk&f 102081) |
| bdbm50021025 |
| 3-[(2-carboxy-ethylsulfanyl)-(2-dodecyl-phenyl)-methylsulfanyl]-propionic acid |
| 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid |
| sk&f-102081 |
| propanoic acid, 3,3'-(((2-dodecylphenyl)methylene)bis(thio))bis- |
| sk&f 102081 |
| SCHEMBL10482314 |
| DTXSID40242649 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (9)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID55051 | Inhibition of leukotriene D4 induced bronchoconstriction in anesthetized guinea pigs after intravenous administration at a dose of 10 mg/kg | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | 3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists. |
| AID55230 | Dissociation constant towards Cysteinyl leukotriene D4 receptor of guinea pig | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists. |
| AID78376 | Antagonistic effect on LTD4 induced change in lung compliance (CDYN) in anesthetized guinea pig, at dose 5 ug/kg, administered intravenously | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists. |
| AID55049 | Inhibition of leukotriene D4 induced bronchoconstriction in anesthetized guinea pigs after aerosol administration as 1% solution | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | 3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists. |
| AID55229 | Binding constant was determined as affinity to displace [3H]LTD4 from Cysteinyl leukotriene D4 receptor on guinea pig lung membrane | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists. |
| AID55064 | Compound is evaluated for its ability to inhibit [3H]LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists. |
| AID73699 | In vitro ability to antagonize a leukotriene D4 induced contraction of guinea pig trachea. | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8 | Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists. |
| AID55057 | Inhibitory activity of compound to block binding of radiolabeled Cysteinyl leukotriene D4 receptor sites in homogenized guinea pig lung at 10 uM | 1989 | Journal of medicinal chemistry, Aug, Volume: 32, Issue:8 | 3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists. |
| AID78375 | Antagonistic effect on LTD4 induced change in air way resistance (RL) in anesthetized guinea pigs, at dose 5 ug/kg, administered intravenously | 1985 | Journal of medicinal chemistry, Sep, Volume: 28, Issue:9 | Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.50
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||