peperomin e profile

peperomin E: an NSAID that inhibits the NF-kappaB signaling pathway; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	10476763
CHEMBL ID	521941
MeSH ID	M0541475

Synonym
peperomin e
CHEMBL521941
(4s)-4-[bis(7-methoxy-1,3-benzodioxol-5-yl)methyl]-3-methylideneoxolan-2-one

Excerpt	Reference	Relevance
"Peperomin E (PepE) is a type of secolignan, a major component of the plant Peperomia dindygulensis. "	( Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE Li, M; Lu, ZY; Ni, XL; Wang, XD; Yan, J, 2018)	3.37
"Peperomin E (PepE) is a type of secolignan that is a major component of the plant Peperomia dindygulensis. "	( The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo. Cheng, Y; Li, N; Liang, JY; Liu, R; Qiu, YY; Wang, XZ; Wen, HM; Wu, H; Yang, XL, 2016)	2.19

Bioassays (38)

Assay ID	Title	Year	Journal	Article
AID430847	Inhibition of TNF-alpha-induced IKK-beta expression in human A549 cells at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430852	Selectivity for inhibition of TNF-alpha-induced cell surface ICAM1 expression over inhibition of TNF-alpha-induced COX2 expression in human A549 cells	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID376934	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 2.5 ug/ml relative to control	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID430849	Inhibition of N-terminal GST-fused human IkappaBalpha (1 to 54) expressed in Escherichia coli BL21	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430831	Antiinflammatory activity in human MCF7 cells assessed as inhibition of TNF-alpha-induced cell surface ICAM1 expression upto 100 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430851	Inhibition of human FLAG-tagged IKK-beta expressed in HEK293 cells at 0.1 to 100 uM by Western blot analysis in presence of ATP	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430836	Antiinflammatory activity in human A549 cells assessed as substantial decrease in IL1-induced cell surface ICAM1 expression at > 10 uM preincubated for 1 hr before IL1 challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430758	Antiinflammatory activity in human A549 cells assessed as reduction of TNF-alpha-induced increase in cell surface ICAM1 expression preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430843	Inhibition of TNF-alpha-stimulated IkappaBalpha degradation in human A549 cells at 0.1 to 100 uM preincubated for 1 hr before TNFalpha challenge measured after 10 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID376936	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 0.25 ug/ml relative to verapamil	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376932	Cytotoxicity against human HepG2 cells	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID430838	Antiinflammatory activity in human A549 cells assessed as complete decrease in IL1-induced cell surface ICAM1 expression at 100 uM preincubated for 1 hr before IL1 challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430844	Inhibition of IL1-stimulated IkappaBalpha degradation in human A549 cells at 0.1 to 100 uM preincubated for 1 hr before IL1 challenge measured after 10 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379732	Growth inhibition of human HL60 cells at 20 uM after 69 hrs	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID430834	Cytotoxicity against human A549 cells upto 100 uM after 6 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430833	Cytotoxicity against human MCF7 cells upto 100 uM after 6 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430835	Antiinflammatory activity in human A549 cells assessed as substantial decrease in TNF-alpha-induced cell surface ICAM1 expression at > 10 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430848	Inhibition of IL1-induced IKK-beta expression in human A549 cells at 100 uM preincubated for 1 hr before IL1 challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430853	Selectivity for inhibition of IL1-induced cell surface ICAM1 expression over inhibition of IL1-induced COX2 expression in human A549 cells	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379734	Growth inhibition of human MCF7 cells at 20 uM after 72 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID376939	Antiinflammatory activity in human A549 cells assessed as inhibition of TNF-alpha-induced ICAM1 induction incubated for 1 hr prior to TNFalpha challenge measured after 6 hrs	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376941	Cytotoxicity against human A549 cells after 24 hrs by MTT assay	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376673	Cytotoxicity against human WI38 cells	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376933	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 0.25 ug/ml relative to control	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376935	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 25 ug/ml relative to control	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID379731	Antiproliferative effect against human HL60 cells after 69 hrs	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID430841	Reduction of TNF-alpha-induced COX2 expression in human A549 cells at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430830	Antiinflammatory activity in human A549 cells assessed as reduction of IL1-induced increase in cell surface ICAM1 expression preincubated for 1 hr before IL1 challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430837	Antiinflammatory activity in human A549 cells assessed as complete decrease in TNF-alpha-induced cell surface ICAM1 expression at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430845	Inhibition of TNF-alpha-induced IKKalpha expression in human A549 cells at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID376938	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 25 ug/ml relative to verapamil	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID430832	Antiinflammatory activity in human MCF7 cells assessed as inhibition of IL1-induced cell surface ICAM1 expression upto 100 uM preincubated for 1 hr before IL1 challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379736	Growth inhibition of human HeLa cells at 20 uM after 69 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID430846	Inhibition of IL1-induced IKKalpha expression in human A549 cells at 100 uM preincubated for 1 hr before IL1 challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379735	Antiproliferative effect against human HeLa cells after 69 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID376937	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 2.5 ug/ml relative to verapamil	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID379733	Antiproliferative effect against human MCF7 cells after 72 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID376674	Cytotoxicity against human VA13 cells	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (25.00)	29.6817
2010's	8 (66.67)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.03	1	aromatic ether; nitrile; polyether; tertiary amino compound
raloxifene raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.	2.03	1	1-benzothiophenes; aromatic ketone; N-oxyethylpiperidine; phenols	bone density conservation agent; estrogen antagonist; estrogen receptor modulator
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	2.13	1	butan-4-olide	metabolite; neurotoxin
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.13	1	cobalt group element atom
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.47	2	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	2.03	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.13	1
savinin savinin: a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation; structure in first source. savinin : A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 1,3-benzodioxol-5-ylmethylidene group at position 3 and a 1,3-benzodioxol-5-ylmethyl group at position 4 (the 3E,4R-isomer). It exhibits antiviral activity against SARS-CoV-2.	7.13	1	benzodioxoles; gamma-lactone; lignan	anti-inflammatory agent; anticoronaviral agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; plant metabolite; T-cell proliferation inhibitor
15-deoxy-delta(12,14)-prostaglandin j2 15-deoxy-delta(12,14)-prostaglandin J2: 15-deoxy-PGJ2 is also available; check for double bonds (indicated by delta) at 12 and 14 positions. 15-deoxy-Delta(12,14)-prostaglandin J2 : A prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions.	2.05	1	prostaglandins J	electrophilic reagent; insulin-sensitizing drug; metabolite

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.81	3
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.81	3
Atherogenesis [description not available]	2.61	2
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	7.61	2
Cancer of Liver [description not available]	2.17	1
Cancer of Stomach [description not available]	2.55	2
Liver Neoplasms Tumors or cancer of the LIVER.	2.17	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.55	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.57	2
Acute Myelogenous Leukemia [description not available]	2.21	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.21	1
Cancer of Prostate [description not available]	2.21	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.21	1
Carcinoma, Anaplastic [description not available]	2.13	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.13	1
Cancer of Lung [description not available]	2.13	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.13	1

peperomin e

Description

Cross-References

Synonyms (3)

Research Excerpts

Overview

Bioassays (38)

Research

Studies (12)

Market Indicators

Research Demand Index: 12.35

Study Types

peperomin e

Description

Cross-References

Synonyms (3)

Research Excerpts

Overview

Bioassays (38)

Research

Studies (12)

Market Indicators

Research Demand Index: 12.35

Study Types

Related Drugs (9)

Related Conditions (17)