peperomin e

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Description

peperomin E: an NSAID that inhibits the NF-kappaB signaling pathway; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	10476763
CHEMBL ID	521941
MeSH ID	M0541475

Synonyms (3)

Synonym
peperomin e
CHEMBL521941
(4s)-4-[bis(7-methoxy-1,3-benzodioxol-5-yl)methyl]-3-methylideneoxolan-2-one

Research Excerpts

Overview

PepE is a type of secolignan, a major component of the plant Peperomia dindygulensis.

Excerpt	Reference	Relevance
"Peperomin E (PepE) is a type of secolignan, a major component of the plant Peperomia dindygulensis. "	( Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE Li, M; Lu, ZY; Ni, XL; Wang, XD; Yan, J, 2018)	3.37
"Peperomin E (PepE) is a type of secolignan that is a major component of the plant Peperomia dindygulensis. "	( The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo. Cheng, Y; Li, N; Liang, JY; Liu, R; Qiu, YY; Wang, XZ; Wen, HM; Wu, H; Yang, XL, 2016)	2.19

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (38)

Assay ID	Title	Year	Journal	Article
AID430847	Inhibition of TNF-alpha-induced IKK-beta expression in human A549 cells at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430852	Selectivity for inhibition of TNF-alpha-induced cell surface ICAM1 expression over inhibition of TNF-alpha-induced COX2 expression in human A549 cells	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID376934	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 2.5 ug/ml relative to control	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID430849	Inhibition of N-terminal GST-fused human IkappaBalpha (1 to 54) expressed in Escherichia coli BL21	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430831	Antiinflammatory activity in human MCF7 cells assessed as inhibition of TNF-alpha-induced cell surface ICAM1 expression upto 100 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430851	Inhibition of human FLAG-tagged IKK-beta expressed in HEK293 cells at 0.1 to 100 uM by Western blot analysis in presence of ATP	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430836	Antiinflammatory activity in human A549 cells assessed as substantial decrease in IL1-induced cell surface ICAM1 expression at > 10 uM preincubated for 1 hr before IL1 challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430758	Antiinflammatory activity in human A549 cells assessed as reduction of TNF-alpha-induced increase in cell surface ICAM1 expression preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430843	Inhibition of TNF-alpha-stimulated IkappaBalpha degradation in human A549 cells at 0.1 to 100 uM preincubated for 1 hr before TNFalpha challenge measured after 10 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID376936	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 0.25 ug/ml relative to verapamil	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376932	Cytotoxicity against human HepG2 cells	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID430838	Antiinflammatory activity in human A549 cells assessed as complete decrease in IL1-induced cell surface ICAM1 expression at 100 uM preincubated for 1 hr before IL1 challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430844	Inhibition of IL1-stimulated IkappaBalpha degradation in human A549 cells at 0.1 to 100 uM preincubated for 1 hr before IL1 challenge measured after 10 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379732	Growth inhibition of human HL60 cells at 20 uM after 69 hrs	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID430834	Cytotoxicity against human A549 cells upto 100 uM after 6 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430833	Cytotoxicity against human MCF7 cells upto 100 uM after 6 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430835	Antiinflammatory activity in human A549 cells assessed as substantial decrease in TNF-alpha-induced cell surface ICAM1 expression at > 10 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430848	Inhibition of IL1-induced IKK-beta expression in human A549 cells at 100 uM preincubated for 1 hr before IL1 challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430853	Selectivity for inhibition of IL1-induced cell surface ICAM1 expression over inhibition of IL1-induced COX2 expression in human A549 cells	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379734	Growth inhibition of human MCF7 cells at 20 uM after 72 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID376939	Antiinflammatory activity in human A549 cells assessed as inhibition of TNF-alpha-induced ICAM1 induction incubated for 1 hr prior to TNFalpha challenge measured after 6 hrs	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376941	Cytotoxicity against human A549 cells after 24 hrs by MTT assay	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376673	Cytotoxicity against human WI38 cells	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376933	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 0.25 ug/ml relative to control	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID376935	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 25 ug/ml relative to control	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID379731	Antiproliferative effect against human HL60 cells after 69 hrs	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID430841	Reduction of TNF-alpha-induced COX2 expression in human A549 cells at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430830	Antiinflammatory activity in human A549 cells assessed as reduction of IL1-induced increase in cell surface ICAM1 expression preincubated for 1 hr before IL1 challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430837	Antiinflammatory activity in human A549 cells assessed as complete decrease in TNF-alpha-induced cell surface ICAM1 expression at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 6 hrs by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID430845	Inhibition of TNF-alpha-induced IKKalpha expression in human A549 cells at 100 uM preincubated for 1 hr before TNFalpha challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID376938	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 25 ug/ml relative to verapamil	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID430832	Antiinflammatory activity in human MCF7 cells assessed as inhibition of IL1-induced cell surface ICAM1 expression upto 100 uM preincubated for 1 hr before IL1 challenge measured after 6 hrs by ELISA	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379736	Growth inhibition of human HeLa cells at 20 uM after 69 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID430846	Inhibition of IL1-induced IKKalpha expression in human A549 cells at 100 uM preincubated for 1 hr before IL1 challenge measured after 5 to 30 mins by Western blot analysis	2009	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15	Peperomins as anti-inflammatory agents that inhibit the NF-kappaB signaling pathway.
AID379735	Antiproliferative effect against human HeLa cells after 69 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID376937	Reversal of multidrug resistance in human AD10 cells assessed as increase in calcein accumulation at 2.5 ug/ml relative to verapamil	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
AID379733	Antiproliferative effect against human MCF7 cells after 72 hrs by MTT assay	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Bioactive compounds from Peperomia pellucida.
AID376674	Cytotoxicity against human VA13 cells	2006	Journal of natural products, May, Volume: 69, Issue:5	Bioactive secolignans from Peperomia dindygulensis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (25.00)	29.6817
2010's	8 (66.67)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.35 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.92 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.35)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.03	1	aromatic ether; nitrile; polyether; tertiary amino compound
raloxifene raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.	2.03	1	1-benzothiophenes; aromatic ketone; N-oxyethylpiperidine; phenols	bone density conservation agent; estrogen antagonist; estrogen receptor modulator
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	2.13	1	butan-4-olide	metabolite; neurotoxin
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.13	1	cobalt group element atom
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.47	2	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	2.03	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.13	1
savinin savinin: a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation; structure in first source. savinin : A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 1,3-benzodioxol-5-ylmethylidene group at position 3 and a 1,3-benzodioxol-5-ylmethyl group at position 4 (the 3E,4R-isomer). It exhibits antiviral activity against SARS-CoV-2.	7.13	1	benzodioxoles; gamma-lactone; lignan	anti-inflammatory agent; anticoronaviral agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; plant metabolite; T-cell proliferation inhibitor
15-deoxy-delta(12,14)-prostaglandin j2 15-deoxy-delta(12,14)-prostaglandin J2: 15-deoxy-PGJ2 is also available; check for double bonds (indicated by delta) at 12 and 14 positions. 15-deoxy-Delta(12,14)-prostaglandin J2 : A prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions.	2.05	1	prostaglandins J	electrophilic reagent; insulin-sensitizing drug; metabolite

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.81	3
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.81	3
Atherogenesis [description not available]	2.61	2
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	7.61	2
Cancer of Liver [description not available]	2.17	1
Cancer of Stomach [description not available]	2.55	2
Liver Neoplasms Tumors or cancer of the LIVER.	2.17	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.55	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.57	2
Acute Myelogenous Leukemia [description not available]	2.21	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.21	1
Cancer of Prostate [description not available]	2.21	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.21	1
Carcinoma, Anaplastic [description not available]	2.13	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.13	1
Cancer of Lung [description not available]	2.13	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.13	1

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