ochromycinone has been researched along with Breast-Neoplasms* in 1 studies
1 other study(ies) available for ochromycinone and Breast-Neoplasms
Article | Year |
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Design, synthesis, and studies of small molecule STAT3 inhibitors.
A series of small molecule STAT3 inhibitors originally derived from our lead compound STA 21 were synthesized and evaluated. The most potent compound in this series, compound 1, exhibited the same anti-proliferative activities as STA 21 against prostate cancer cell lines that express constitutively active STAT3. Molecular docking showed compound 1 bound to the STAT3beta SH2 domain in a similar manner as STA 21. Topics: Anthraquinones; Antineoplastic Agents; Benz(a)Anthracenes; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Drug Design; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Male; Models, Molecular; Prostatic Neoplasms; src Homology Domains; STAT3 Transcription Factor; Structure-Activity Relationship | 2008 |