n-nitroso(2-hydroxypropyl)(2-oxopropyl)amine profile

N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	43677
MeSH ID	M0061537

Synonym
hpop
acetone, 1-((2-hydroxypropyl)-nitrosoamino)-
n-nitroso(2-hydroxypropyl)(2-oxypropyl)amine
ccris 2013
2-propanone, 1-((2-hydroxypropyl)nitrosoamino)-
n-nitros(2-hydroxypropyl)(2-oxopropyl)amine
1-((2-hydroxypropyl)-nitrosoamino)acetone
1-((2-hydroxypropyl)nitrosoamino)-2-propanone
n-nitroso(2-hydroxypropyl)(2-oxopropyl)amine
n-(2-hydroxypropyl)-n-(2-oxopropyl)nitrous amide
AKOS006279277
61499-28-3
DTXSID60977062
1-[(2-hydroxypropyl)nitrosoamino]-2-propanone

Excerpt	Reference	Relevance
" We have investigated the toxic effects of these compounds on pancreatic tissues from Wistar rats and Syrian hamsters."	( Cellular toxicity of pancreatic carcinogens. Archer, MC; Chan, AM; Zucker, PF, 1986)	0.27

Excerpt	Reference	Relevance
" This 12-mo study was carried out to investigate the effects of orchiectomy, alone and in combination with testosterone, and of treatment with cyproterone acetate on pancreatic carcinogenesis in azaserine-treated rats and BOP-treated hamsters."	( Effects of orchiectomy, alone or in combination with testosterone, and cyproterone acetate on exocrine pancreatic carcinogenesis in rats and hamsters. de Jong, FH; Foekens, JA; Klijn, JG; Lamberts, SW; Meijers, M; van Garderen-Hoetmer, A; Visser, CJ; Woutersen, RA, 1992)	0.28

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	27 (77.14)	18.7374
1990's	8 (22.86)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
orotic acid Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.. orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.	7.38	2	pyrimidinemonocarboxylic acid	Escherichia coli metabolite; metabolite; mouse metabolite
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	1.97	1	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
glutamine Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.. L-glutamine : An optically active form of glutamine having L-configuration.. glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.	1.96	1	amino acid zwitterion; glutamine family amino acid; glutamine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
n-nitrosomorpholine N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.	1.95	1	nitrosamine	carcinogenic agent; mutagen
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	1.96	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.	1.97	1	nitrosamine	geroprotector; mutagen
cyproterone acetate [no description available]	1.98	1	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; chlorinated steroid; steroid ester	androgen antagonist; geroprotector; progestin
n-nitrosodiethanolamine [no description available]	1.97	1	nitroso compound
n-nitroso-2,6-dimethylmorpholine N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation	3.47	8
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	1.96	1	dihydrogen
diisopropanolnitrosamine diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.	4.04	15	diol; nitrosamine; secondary alcohol	carcinogenic agent
nitrosobis(2-oxopropyl)amine nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).	4.36	21	ketone; nitrosamine	carcinogenic agent
n-nitrosobis(2-oxobutyl)amine N-nitrosobis(2-oxobutyl)amine: structure given in first source	1.96	1
o-(6)-methylguanine O-(6)-methylguanine: structure. 6-O-methylguanine : A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.. methylguanine : A 2-aminopurine that is guanine bearing a single methyl substituent.	1.98	1	methylguanine	mutagen
n-nitrosobis(2-acetoxypropyl)amine [no description available]	1.96	1
n-nitrosomethyl-2-oxopropylamine N-nitrosomethyl-2-oxopropylamine: RN & N1 from 9th CI Form Index; structure in first source	2.65	3
n-nitrosomethyl-2-hydroxypropylamine N-nitrosomethyl-2-hydroxypropylamine: RN & N1 from CA Form Index; RN given refers to parent cpd without isomeric designation; structure in first source	2.36	2
azaserine Azaserine: Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.. azaserine : A carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species.	2.38	2	carboxylic ester; diazo compound; L-serine derivative; non-proteinogenic L-alpha-amino acid	antifungal agent; antimetabolite; antimicrobial agent; antineoplastic agent; glutamine antagonist; immunosuppressive agent; metabolite
thioguanine anhydrous Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.. tioguanine : A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.	1.96	1	2-aminopurines	anticoronaviral agent; antimetabolite; antineoplastic agent
cyproterone Cyproterone: An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.	1.98	1	17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(4) steroid; chlorinated steroid; tertiary alpha-hydroxy ketone	androgen antagonist
guanine [no description available]	1.98	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
7-methylguanine 7-methylguanine: RN given refers to unlabeled cpd; structure. 7-methylguanine : A methylguanine that is guanine substituted by a methyl group at position 7. It is a metabolite obtained during the methylation of DNA.. 2-imino-7-methyl-1,2,3,7-tetrahydro-6H-purin-6-one : A 7-methylguanine that is 1,2,3,7-tetrahydro-6H-purin-6-one substituted by an imino group at position 2 and a methyl group at position 7.. 2-amino-7-methyl-7H-purin-6-ol : A 7-methylguanine that is 7H-purine substituted by an amino group at position 2, a methyl group at position 7 and a hydroxy group at position 6.. 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one : A 7-methylguanine that is 1,7-dihydro-6H-purin-6-one substituted by an amino group at position 2 and a methyl group at position 7.	1.98	1	7-methylguanine

Condition	Relationship Strength	Studies
Adenocarcinoma, Basal Cell [description not available]	2.37	2
Bile Duct Cancer [description not available]	1.95	1
Carcinoma, Anaplastic [description not available]	2.65	3
Cholangioma [description not available]	1.95	1
Cancer of Head [description not available]	1.95	1
Cancer of Liver [description not available]	3.06	5
Cancer of Pancreas [description not available]	4.27	19
Papilloma, Squamous Cell [description not available]	2.36	2
Cancer of Skin [description not available]	1.95	1
Cancer of Nose [description not available]	1.95	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.37	2
Bile Duct Neoplasms Tumors or cancer of the BILE DUCTS.	1.95	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.65	3
Adenoma, Bile Duct A benign tumor of the intrahepatic bile ducts.	1.95	1
Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	1.95	1
Liver Neoplasms Tumors or cancer of the LIVER.	3.06	5
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	4.27	19
Papilloma A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	2.36	2
Skin Neoplasms Tumors or cancer of the SKIN.	1.95	1
Cancer of Lung [description not available]	2.88	4
Experimental Neoplasms [description not available]	3.35	7
Lung Neoplasms Tumors or cancer of the LUNG.	2.88	4
Cancer of Lip [description not available]	1.95	1
Cancer of the Vagina [description not available]	1.95	1
Vaginal Neoplasms Tumors or cancer of the VAGINA.	1.95	1
Cholangiocellular Carcinoma [description not available]	1.98	1
Cancer of Gallbladder [description not available]	1.98	1
Experimental Hepatoma [description not available]	1.98	1
Condition, Preneoplastic [description not available]	1.98	1
Gallbladder Neoplasms Tumors or cancer of the gallbladder.	1.98	1
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	1.98	1
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	1.98	1
Cholangiocarcinoma A malignant tumor arising from the epithelium of the BILE DUCTS.	1.98	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	1.98	1
Atypical Ductal Hyperplasia [description not available]	1.95	1
Cancer of Digestive System [description not available]	1.95	1
Genito-urinary Cancer [description not available]	1.95	1
Respiratory Tract Neoplasms New abnormal growth of tissue in the RESPIRATORY SYSTEM.	1.95	1
Carcinoma, Intraductal, Noninfiltrating A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.	1.95	1
Digestive System Neoplasms Tumors or cancer of the DIGESTIVE SYSTEM.	1.95	1
Urogenital Neoplasms Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.	1.95	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.38	2
Cancer of Kidney [description not available]	1.97	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.97	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.97	1
Adenoma, Basal Cell [description not available]	2.37	2
Lymph Node Metastasis [description not available]	1.96	1
Adenoma A benign epithelial tumor with a glandular organization.	2.37	2

n-nitroso(2-hydroxypropyl)(2-oxopropyl)amine

Description

Cross-References

Synonyms (14)

Research Excerpts

Toxicity

Compound-Compound Interactions

Research

Studies (35)

Market Indicators

Research Demand Index: 10.68

Study Types

n-nitroso(2-hydroxypropyl)(2-oxopropyl)amine

Description

Cross-References

Synonyms (14)

Research Excerpts

Toxicity

Compound-Compound Interactions

Research

Studies (35)

Market Indicators

Research Demand Index: 10.68

Study Types

Related Drugs (22)

Related Conditions (48)