mycothiazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

mycothiazole: from Cacospongia mycofijiensis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	6443333
CHEMBL ID	4540502
CHEBI ID	69137
MeSH ID	M0496026

Synonyms (10)

Synonym
mycothiazole
carbamic acid, ((4z,7r)-8-(4-((2z)-2,5-hexadienyl)-2-thiazolyl)-7-hydroxy-8-methyl-3-methylene-4-nonenyl)-, methyl ester
(-)-mycothiazole
114582-75-1
(r)-(-)-mycothiazole
methyl n-[(z,7r)-8-[4-[(2e)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-7-hydroxy-8-methyl-3-methylidenenon-4-enyl]carbamate
CHEBI:69137
Q27137476
CHEMBL4540502
DTXSID301037231

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

Class	Description
thiazoles	An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID1578535	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring relative abundance measured after preserving compound in amber vial con	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578528	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring maximum absorbance units measured after preserving compound in amber vi	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578530	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring maximum absorbance units measured after preserving compound in amber vi	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578529	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring maximum absorbance units measured after preserving compound in amber vi	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578537	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring relative abundance measured after preserving compound in amber vial con	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578539	Stability of compound assessed as shelf life measured after preserving compound in amber vial containing 95% CH3CN and 5% H2O followed by drying using N2 stream and later punged-with argon in dark desiccator under vacuum for 24 hrs	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578536	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring relative abundance measured after preserving compound in amber vial con	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578534	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring relative abundance measured after preserving compound in amber vial con	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578525	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578533	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by relative abundance measured after preserving compound in amber vial containing 95	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578540	Stability of compound assessed as shelf life measured after preserving compound in amber vial containing 95% CH3CN and 5% H2O followed by drying using N2 stream and later punged-with argon followed by exposure to 4 degC for 24 hrs	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578532	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring maximum absorbance units measured after preserving compound in amber vi	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578531	Drug degradation assessed as methyl N-[(E)-8-[4-[(2E)-hexa-2,5-dienyl]-1,3-thiazol-2-yl]-3,7-dihydroxy-3-(hydroxymethyl)-8-methylnon-4-enyl]carbamate metabolite formation by measuring maximum absorbance units measured after preserving compound in amber vi	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578527	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
AID1578526	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 3 days by tryphan blue dye based assay	2020	ACS medicinal chemistry letters, Feb-13, Volume: 11, Issue:2	Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	3 (37.50)	24.3611
2020's	2 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.94 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.94)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.25	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
fluoroform fluoroform: structure	2.25	1	fluoromethanes	refrigerant
allyl alcohol allyl alcohol: structure. allylic alcohol : An alcohol where the hydroxy group is attached to a saturated carbon atom adjacent to a double bond (R groups may be H, organyl, etc.).. allyl alcohol : A propenol in which the C=C bond connects C-2 and C-3. It is has been found in garlic (Allium sativum). Formerly used as a herbicide for the control of various grass and weed seeds.	2.25	1	primary allylic alcohol; propenol	antibacterial agent; fungicide; herbicide; insecticide; plant metabolite
thiazoles [no description available]	3.44	7	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
thiazolidines Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.	2.03	1	thiazolidine
latrunculin a latrunculin A: 16-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica; see also latrunculin B; structure given in first source. latrunculin A : A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.	2.03	1	cyclic hemiketal; macrolide; oxabicycloalkane; thiazolidinone	actin polymerisation inhibitor; metabolite; toxin
epothilone b [no description available]	2.03	1	epothilone; epoxide	antineoplastic agent; apoptosis inducer; microtubule-stabilising agent
epothilone a Epothilones: A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).	2.03	1	epothilone; epoxide	antineoplastic agent; metabolite; microtubule-stabilising agent; tubulin modulator
oxazolone Oxazolone: Immunologic adjuvant and sensitizing agent.	2.03	1

chemdatabank.com