monocillin-i and hypothemycin

monocillin-i has been researched along with hypothemycin* in 1 studies

Other Studies

1 other study(ies) available for monocillin-i and hypothemycin

Article	Year
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. Journal of natural products, 2017, 08-25, Volume: 80, Issue:8 Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii. Topics: Antifungal Agents; HeLa Cells; Humans; Hydroxybenzoate Ethers; Hydroxybenzoates; Lactones; Macrolides; Molecular Structure; Paecilomyces; Phytophthora; X-Ray Diffraction; Zearalenone	2017

Article

Year

Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.

Journal of natural products, 2017, 08-25, Volume: 80, Issue:8

Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.

Topics: Antifungal Agents; HeLa Cells; Humans; Hydroxybenzoate Ethers; Hydroxybenzoates; Lactones; Macrolides; Molecular Structure; Paecilomyces; Phytophthora; X-Ray Diffraction; Zearalenone

2017