Compounds > monocillin ii
Page last updated: 2024-12-11

monocillin ii

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

monocillin II: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6478915
CHEMBL ID498851
MeSH IDM0545264

Synonyms (5)

Synonym
1h-2-benzoxacyclotetradecin-1,11(12h)-dione, 3,4,7,8-tetrahydro-16-hydroxy-3-methyl-, (3s)-
(4e,8e,11s)-15-hydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),4,8,15,17-pentaene-3,13-dione
monocillin ii
CHEMBL498851
(4s,6e,10e)-18-hydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,10,15,17-pentaene-2,12-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID745762Displacement of [3H]-CP55940 from human recombinant CB2 receptor transfected in HEK293 cells at 10 uM after 90 mins relative to control2013Journal of natural products, 05-24, Volume: 76, Issue:5
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors.
AID427104Inhibition of WNT5A mRNA expression in human dermal papilla cells after 24 hrs by quantigene assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
AID356002Cytotoxicity against african green monkey Vero cells at 5 uM by crystal violet staining2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID427105Cytotoxicity against human dermal papilla cells by Alamar blue assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity.
AID356008Agonist activity at ERbeta up to 10 uM by fluorescence polarization assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID745767Displacement of [3H]-U-69593 from human kappa opioid receptor transfected in CHOK1 cells at 10 uM after 60 mins relative to control2013Journal of natural products, 05-24, Volume: 76, Issue:5
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors.
AID745763Displacement of [3H]-CP55940 from human recombinant CB1 receptor transfected in HEK293 cells at 10 uM after 90 mins relative to control2013Journal of natural products, 05-24, Volume: 76, Issue:5
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors.
AID355998Antiviral activity against HSV1 F infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathic effect by cellular replication assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID356004Antiparasitic activity against Eimeria tenella Houghton infected in PCKC at 10 ppm treated 2 hrs postinfection by MMDA assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID745765Displacement of [3H]-enkephalin from human delta opioid receptor transfected in CHOK1 cells at 10 uM after 60 mins relative to control2013Journal of natural products, 05-24, Volume: 76, Issue:5
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors.
AID356006Antiparasitic activity against Neospora caninum NC-1 infected in african green monkey Vero cells treated 2 hrs postinfection by MMDA assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID356009Cytotoxicity against PCKC by crystal violet staining2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
AID745766Displacement of [3H]-DAMGO from human mu opioid receptor transfected in CHOK1 cells at 10 uM after 60 mins relative to control2013Journal of natural products, 05-24, Volume: 76, Issue:5
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors.
AID356005Antiparasitic activity against Eimeria tenella Houghton infected in PCKC at 1 ppm treated 2 hrs postinfection by MMDA assay2003Journal of natural products, Jun, Volume: 66, Issue:6
Pochonins A-F, new antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
threonine
Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.		2.0710amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
taleranol
taleranol: a metabolite of ZEARALENONE which is a non-steroidal estrogenic lactone used as an anabolic compound in animal feed; a stereoisomer of ZERANOL (alpha-zearalanol)		2.0110macrolide
cp-55,940
[no description available]		2.0810
Zearalanone
[no description available]		2.0110macrolide;
resorcinols
zeranol
Zeranol: A non-steroidal estrogen analog.		2.0110macrolide
zearalenone
Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.		2.0110macrolide;
resorcinols		fungal metabolite;
mycoestrogen
naloxone
Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.		2.0810morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
monorden
monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II		2.9640cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols		antifungal agent;
metabolite;
tyrosine kinase inhibitor
monocillin i
monocillin I: structure in first source		2.4520
pseurotin
pseurotin: metabolite isolated from culture filtrates of Pseudeurotium ovalis Stolk; structure. pseurotin A : A spirocyclic that is 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione bearing 1,2-dihydroxyhex-3-en-1-yl, methyl, methoxy, benzoyl and hydroxy substituents at positions 2, 3, 8, 8 and 9 respectively.		2.0110azaspiro compound;
lactam;
oxaspiro compound		metabolite
pochonin d
pochonin D: secondary metabolite of Pochonia chlamydosporia; structure in first source		2.0110
monocillin iii
monocillin III: structure in first source		2.7330
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		07.0710
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0710