Page last updated: 2024-11-05

methazid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

methazid: major descriptor (66-85); on-line search ISONIAZID/AA (66-85); Index Medicus search METHAZID (66-85) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15568
CHEMBL ID1526558
SCHEMBL ID2109857
MeSH IDM0262988

Synonyms (43)

Synonym
nsl1m7ifyp ,
unii-nsl1m7ifyp
4-22-00-00562 (beilstein handbook reference)
metazidum
metazida
metazide
bis(isonicotinylhydrazo)methane
methazide
1707-15-9
isonicotinic acid 2,2'-methylenedihydrazide
metazid
methazid
n,n-methylenebisisoniazid
nsc39302
ro 24969
nsc-39302
4-pyridinecarboxylic acid,2'-methylenedihydrazide
ro 2-4969
isonicotinic acid,2'-methylenedihydrazide
metazidum [inn-latin]
metazida [spanish]
metazide [inn]
metazidum [latin]
metazida [inn-spanish]
1,1'-methylenebis(2-isonicotinylhydrazine)
methazidum
4-pyridinecarboxylic acid, 2,2'-methylenedihydrazide
nsc 39302
brn 0294524
NCGC00160572-01
n'-[[2-(pyridine-4-carbonyl)hydrazinyl]methyl]pyridine-4-carbohydrazide
dtxsid9046239 ,
cas-1707-15-9
dtxcid7026239
tox21_111909
AKOS024332405
CHEMBL1526558
metazide [who-dd]
SCHEMBL2109857
sr-01000945017
SR-01000945017-1
FT-0769966
Q27285034

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
" Use of suppository methazide in combination with riboflavin (100 micrograms per animal which is a recommended daily dose) prevents B2 deficiency."( [The use of preparations of methazid combined with riboflavin and pyridoxine for the correction of methazid-induced metabolic disorders of the B-group vitamins in rats].
Iakushina, LM; Kharitonchik, LA; Kodentsova, VM; Kovalenko, TA; Sokol'nikov, AA; Sonin, BV; Stroev, EA, 1993
)
0.9

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
phosphopantetheinyl transferaseBacillus subtilisPotency79.43280.141337.9142100.0000AID1490
GLS proteinHomo sapiens (human)Potency28.18380.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency27.31710.000811.382244.6684AID686978; AID686979
aryl hydrocarbon receptorHomo sapiens (human)Potency6.26100.000723.06741,258.9301AID743085; AID743122
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-199024 (85.71)18.7374
1990's1 (3.57)18.2507
2000's0 (0.00)29.6817
2010's2 (7.14)24.3611
2020's1 (3.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 15.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index15.87 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.10 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (15.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]