Page last updated: 2024-12-05
makaluvamine a
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
makaluvamine A: from fruiting bodies of Didymium bahiense; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 4002 |
| CHEMBL ID | 449905 |
| SCHEMBL ID | 9262213 |
| MeSH ID | M0390291 |
Synonyms (15)
| Synonym |
|---|
| pyrrolo[4,3,2-de]quinolin-8(1h)-one, 7-amino-3,4-dihydro-1-methyl- |
| 146555-78-4 |
| makaluvamine a |
| nsc700008 |
| b725050k179 |
| pyrrolo[4,2-de]quinolin-8(1h)-one, 7-amino-3,4-dihydro-1-methyl- |
| nsc-700008 |
| CHEMBL449905 |
| pyrrolo(4,3,2-de)quinolin-8(1h)-one, 7-amino-3,4-dihydro-1-methyl- |
| nsc 700008 |
| SCHEMBL9262213 |
| DTXSID10163397 |
| 10-amino-2-methyl-2,7-diazatricyclo[6.3.1.04,12]dodeca-1(12),3,7,9-tetraen-11-one |
| 7-amino-1-methyl-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1h)-one |
| STARBLD0004927 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Other Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC90 (µMol) | 41.0000 | 1.1000 | 1.1000 | 1.1000 | AID691744 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (16)
Molecular Functions (13)
Ceullar Components (12)
Bioassays (8)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID691744 | Inhibition of topoisomerase 2 by decatenation assay | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12 | Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. |
| AID691745 | Cytotoxicity against Chinese hamster Xrs-6 cells | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12 | Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. |
| AID355150 | Cytotoxicity against mouse P388 cells | 1996 | Journal of natural products, Nov, Volume: 59, Issue:11 | Makaluvic acids A and B: novel alkaloids from the marine sponge Zyzzya fuliginosus. |
| AID360578 | Cytotoxicity against human HCT116 cells | 1995 | Journal of natural products, Dec, Volume: 58, Issue:12 | Makaluvamines H-M and damirone C from the pohnpeian sponge Zyzzya fuliginosa. |
| AID334593 | Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay | 2002 | Journal of natural products, May, Volume: 65, Issue:5 | Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa. |
| AID691737 | Cytotoxicity against human HCT116 cells | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12 | Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp. |
| AID360579 | Inhibition of DNA topoisomerase 2 | 1995 | Journal of natural products, Dec, Volume: 58, Issue:12 | Makaluvamines H-M and damirone C from the pohnpeian sponge Zyzzya fuliginosa. |
| AID334594 | Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 at 1 ug/ml after 2.5 hrs by beta galactosidase report gene assay | 2002 | Journal of natural products, May, Volume: 65, Issue:5 | Batzelline D and isobatzelline E from the indopacific sponge Zyzzya fuliginosa. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.35
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.35) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||