| Assay ID | Title | Year | Journal | Article |
|---|
| AID265775 | Decrease in dissociation of [125I]I-AB-MECA from human adenosine A3 receptor in CHO membrane at 10 uM relative to control after 30 min | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
| Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
| AID370762 | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells at 10 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
| A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. |
| AID370767 | Intrinsic activity at human adenosine A3 receptor expressed in CHO cells assessed as increase in C1IB-MECA-stimulated inhibition of forskolin-induced cAMP release at 10 uM by TR-FRET assay | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
| A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. |
| AID1849420 | Positive allosteric modulator activity in human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as decrease in radioligand [125I]I-AB-MECA dissociation from A3AR receptor by measuring remaining radioligand-bound receptor at 10 | | | |
| AID265772 | Agonist activity at human adenosine A2B receptor assessed as inhibition of NECA-induced cAMP accumulation in CHO membrane at 10 uM | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
| Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
| AID265774 | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor in CHO membrane at 10 uM | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
| Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
| AID418848 | Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells at 10 uM | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor. |
| AID370761 | Displacement of [125I]AB-MECA from human adenosine A1 receptor expressed in CHO cells at 10 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
| A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. |
| AID370764 | Displacement of [3H]MRS1754 from human adenosine A2B receptor expressed in CHO cells at 10 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
| A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. |
| AID1232373 | Positive allosteric modulator activity at human A3 adenosine receptor assessed as potentiation of maximum efficacy of Cl-IB-MECA | 2015 | Bioorganic & medicinal chemistry, Jul-15, Volume: 23, Issue:14
| Understanding allosteric interactions in G protein-coupled receptors using Supervised Molecular Dynamics: A prototype study analysing the human A3 adenosine receptor positive allosteric modulator LUF6000. |
| AID418847 | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293 cells at 10 uM | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor. |
| AID418850 | Increase in efficacy of stimulation of [35S]GTPgammaS binding to human adenosine A3 receptor expressed in CHO cells at 10 uM by liquid scintillation counting relative to C1-IB-MECA | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor. |
| AID370763 | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cells at 10 uM | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
| A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. |
| AID265769 | Displacement of [3H]R-PIA from human adenosine A1 receptor in CHO membrane at 10 uM | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
| Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
| AID370765 | Binding affinity to human adenosine A1 receptor expressed in CHO cells assessed as enhancement of DPCPX-induced displacement of [125I]AB-MECA from receptor at 10 uM after 90 mins relative to control | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
| A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. |
| AID1849421 | Positive allosteric modulator activity in human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as net change in radioligand [125I]I-AB-MECA equilibrium binding to A3AR receptor at 10 uM incubated for 18 hrs by radioligand com | | | |
| AID370766 | Binding affinity to human adenosine A3 receptor expressed in CHO cells assessed as enhancement of C1IB-MECA-induced displacement of [125I]AB-MECA from receptor at 10 uM after 90 mins relative to control | 2009 | Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
| A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. |
| AID1849422 | Positive allosteric modulator activity in wild type human A3AR opioid receptor stably expressed in human HEK293 cell membrane assessed as increase in CI-IB-MECA induced [35S]GTPGAgammaS binding to receptor at 1 uM preincubated for 1 hrs with CI-IB-MECA fu | | | |
| AID418849 | Decrease in dissociation of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells at 10 uM after 60 mins relative to control | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor. |
| AID706373 | Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as potentiation of Cl-IB-MECA-induced [35S]GTPgammaS binding after 20 mins | 2012 | Journal of medicinal chemistry, Jun-28, Volume: 55, Issue:12
| Medicinal chemistry of A₃ adenosine receptor modulators: pharmacological activities and therapeutic implications. |
| AID418846 | Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells at 10 uM | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor. |
| AID1849483 | Positive allosteric modulator activity in human wild type A3AR receptor stably expressed in human HEK293 cell membrane assessed as inhibition of radioligand [125I]-ABOPX orthosteric binding incubated for 18 hrs in presence of PSB603 by equilibrium radioli | | | |
| AID265776 | Increase of efficacy at human adenosine A3 receptor in CHO membrane at 10 uM relative to 2-Cl-IB-MECA | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
| Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
| AID265771 | Displacement of [3H]R-PIA from human adenosine A2A receptor in HEK293 cells at 10 uM | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
| Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1345822 | Human A3 receptor (Adenosine receptors) | 2006 | Journal of medicinal chemistry, Jun-01, Volume: 49, Issue:11
| Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |