Compounds > gephyrotoxin
Page last updated: 2024-11-11

gephyrotoxin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

gephyrotoxin: alkaloid from Colombian frog Dendrobates histrionicus [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6437870
MeSH IDM0063162

Synonyms (18)

Synonym
gephyrotoxin
2-[(1r,3ar,5ar,6r,9as)-6-[(z)-pent-2-en-4-ynyl]-1,2,3,3a,4,5,5a,6,7,8,9,9a-dodecahydropyrrolo[1,2-a]quinolin-1-yl]ethanol
(1s,3as,5as,6s(z),9ar,10r)dodecahydro-6-(2-penten-4-yl)pyrrolo(1,2-a)quinoline-1-ethanol
pyrrolo(1,2-a)quinoline-1-ethanol, dodecahydro-6-(2-penten-4-ynyl)-, (1r-(1alpha,3abeta,5aalpha,6alpha(z),9aalpha))-
pyrrolo(1,2-a)quinoline-1-ethanol, dodecahydro-6-(2z)-2-penten-4-ynyl-, (1r,3ar,5ar,6r,9as)-
histrionicotoxin d
htx d
unii-01n796r81a
01n796r81a ,
55893-12-4
pyrrolo(1,2-a)quinoline-1-ethanol, dodecahydro-6-(2-penten-4-ynyl)-, (1alpha,3abeta,5aalpha,6alpha(z),9aalpha)-
75685-48-2
gephyrotoxin [mi]
(1r,3ar,5ar,6r,9as)-dodecahydro-6-(2z)-2-penten-4-ynylpyrrolo(1,2-a)quinoline-1-ethanol
gephyrotoxin, (-)-
(1r,3ar,5ar,6r,9as)-dodecahydro-6-(2z)-2-penten-4-ynylpyrrolo[1,2-a]quinoline-1-ethanol
Q5548689
DTXSID401029722
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (50.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's4 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.01 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycine
[no description available]		2.0410alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
carbachol
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.		1.9610ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		210monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		210pyrrole;
secondary amine
indolizine
[no description available]		1.9610indolizines;
mancude organic heterobicyclic parent
muscarine
Muscarine: A toxic alkaloid found in Amanita muscaria (fly fungus) and other fungi of the Inocybe species. It is the first parasympathomimetic substance ever studied and causes profound parasympathetic activation that may end in convulsions and death. The specific antidote is atropine.		1.9510monosaccharide
scandium
Scandium: An element of the rare earth family of metals. It has the atomic symbol Sc, atomic number 21, and atomic weight 45.		2.110d-block element atom;
rare earth metal atom;
scandium group element atom
n-phenylethanolamine
[no description available]		2.0410aralkylamine
pumiliotoxin c
pumiliotoxin C: isolated from skin of Dendrobates pumilio (frog); see also records for pumiliotoxin A, pumiliotoxin B & pumiliotoxins		3.0610
scandium triflate
scandium triflate: structure in first source		2.110
pumiliotoxin a
pumiliotoxin A: see also records for pumiliotoxin B, pumiliotoxin C & pumiliotoxins		3.0610alkaloid
histrionicotoxin
histrionicotoxin: toxin isolated from Colombian frog, Dendrobates histrionicus; structure. histrionicotoxin : An azaspiro compound that is 1-azaspiro[5.5]undecane substituted by a hydroxy group at position 8, a but-1-en-3-yn-1-yl group at position 7 and a pent-3-en-1-yn-5-yl group at position 2 (the 2S,6R,7S,8S stereoisomer).		3.0610
piperidines
Piperidines: A family of hexahydropyridines.		3.0610
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9610