genipin 1-gentiobioside: from Gardenia fructus (zhi-zi) [MeSH]
Genipin 1-beta-gentiobioside : no description available [CHeBI]
| ID Source | ID |
|---|---|
| PubMed CID | 3082301 |
| CHEMBL ID | 504969 |
| CHEBI ID | 80829 |
| MeSH ID | M0164219 |
| Synonym |
|---|
| cyclopenta(c)pyran-4-carboxylic acid, 1-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1r-(1alpha,4aalpha,7aalpha))- |
| genipin 1-gentiobioside |
| unii-0ni5399rdz |
| 0ni5399rdz , |
| gbgb |
| 29307-60-6 |
| C16965 |
| genipin 1-beta-gentiobioside |
| genipin gentiobioside |
| CHEMBL504969 |
| chebi:80829 , |
| methyl (1s,4as,7as)-7-(hydroxymethyl)-1-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate |
| S3270 |
| AC-34358 |
| genipin 1-.beta.-gentiobioside |
| genipin 1-o-gentiobioside |
| cyclopenta(c)pyran-4-carboxylic acid, 1-((6-o-.beta.-d-glucopyranosyl-.beta.-d-glucopyranosyl)oxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1s,4as,7as)- |
| genipin 1-o-.beta.-d-gentiobioside |
| genipin 1-.beta.-d-gentiobioside |
| CS-0018599 |
| genipin 1-|a-d-gentiobioside |
| HY-N2094 |
| DTXSID50183554 |
| genipin-gentiobioside |
| NCGC00347524-02 |
| AKOS032946013 |
| genipin-1-b-d-gentiobioside |
| Q27149871 |
| F17696 |
| genipin 1-o-beta-d-gentiobioside |
| mfcd12031626 |
| genipin 1-b-gentiobioside |
| genipin 1-b-d-gentiobioside |
| genipin 1-beta-d-gentiobioside |
| MS-30068 |
| genipin 1-gentiobioside; genipin 1--gentiobioside; genipin gentiobioside |
| genipin 1--d-gentiobioside |
| methyl (1s,4as,7as)-7-(hydroxymethyl)-1-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-((((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)methyl)tetrahydro-2h-pyran-2-yl)oxy)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate |
| A924149 |
| Class | Description |
|---|---|
| terpene glycoside | A terpenoid in which one or more hydroxy functions are glycosylated. |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 ISSN: 2472-5560 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID399060 | Immunosuppressive activity against human peripheral blood T cells assessed as inhibition of PMA and anti-CD28 monoclonal antibody-costimulated IL2 secretion at 100 ug/ml by ELISA | 2005 | Journal of natural products, Nov, Volume: 68, Issue:11 ISSN: 0163-3864 | Immunosuppressive iridoids from the fruits of Gardenia jasminoides. |
| AID725307 | Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4 ISSN: 1464-3405 | Chemical constituents from the fruit of Gardenia jasminoides and their inhibitory effects on nitric oxide production. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cornin iridoid | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| thymol-beta-d-glucopyranoside | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| geniposide | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| pentaacetyl geniposide | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| patrinoside | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| ibuprofen acyl glucuronide | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| agnuside | benzoate ester; beta-D-glucoside; cyclopentapyran; iridoid monoterpenoid; monosaccharide derivative; phenols; terpene glycoside | anti-inflammatory agent; cyclooxygenase 2 inhibitor; plant metabolite; pro-angiogenic agent | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | ||
| geniposidic acid | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| harpagoside | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| geranyl glucoside | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| tetronasin | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| sambutoxin | terpene glycoside | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| geniposide | terpene glycoside | 2005 | 2013 | 15.0 | medium | 0 | 0 | 0 | 1 | 1 | 0 | ||
| genipin | iridoid monoterpenoid | anti-inflammatory agent; antioxidant; apoptosis inhibitor; cross-linking reagent; hepatotoxic agent; uncoupling protein inhibitor | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| gardenia yellow | diester; disaccharide derivative; diterpenoid | antioxidant; food colouring; histological dye; plant metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| glucose, (beta-d)-isomer | D-glucopyranose | epitope; mouse metabolite | 1988 | 2010 | 25.0 | medium | 0 | 1 | 0 | 1 | 0 | 0 | |
| geniposide | terpene glycoside | 1988 | 2010 | 25.0 | medium | 0 | 1 | 0 | 1 | 0 | 0 | ||
| geniposidic acid | terpene glycoside | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 | ||
| iridoids | 1988 | 2010 | 25.0 | medium | 0 | 1 | 0 | 1 | 0 | 0 | |||
| likviriton | beta-D-glucoside; flavanone glycoside; monohydroxyflavanone; monosaccharide derivative | anti-inflammatory agent; anticoronaviral agent; plant metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| glycosides | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 | |||
| gardenoside | beta-D-glucoside; cyclopentapyran; enoate ester; methyl ester; monosaccharide derivative; tertiary alcohol | metabolite | 1988 | 1988 | 36.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 | |
| peoniflorin | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Congenital Zika Syndrome | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 | |
| Disease Models, Animal | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 | |
| Zika Virus Infection | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 |
| Article | Year |
|---|---|
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5 | 2019 |