furanomycin

Description

Furanomycin is a naturally occurring antibiotic produced by the bacterium *Streptomyces furukawaensis*. It inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, specifically to the peptidyl transferase center. This inhibition blocks the formation of peptide bonds, preventing protein synthesis and ultimately leading to bacterial cell death. Furanomycin has shown promising antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including *Staphylococcus aureus*, *Escherichia coli*, and *Pseudomonas aeruginosa*. It has also been shown to exhibit antifungal activity against *Candida albicans*. However, furanomycin has not been developed for clinical use due to its potential toxicity. Research efforts have focused on understanding its mechanism of action, exploring its potential as a lead compound for the development of new antibiotics, and investigating its potential to combat multidrug-resistant bacteria.'

furanomycin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

furanomycin : A non-proteinogenic L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (2R,5S)-5-methyl-2,5-dihydrofuran-2-yl moiety. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]