ap-10 and Alzheimer-Disease

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and remains incurable. Currently, neuronal injury and synapse loss have been considered to be main features in the pathophysiology of AD. Thus, modulation of neuronal survival and neurite outgrowth may represent an efficient strategy for the treatment of AD. Based on the isolates from the traditional medicine Andrographis paniculata, a series of andrographolide analogues were prepared and evaluated for the neuroprotection and neurotrophic activity. Two compounds (3 and 12) could effectively inhibit LPS-induced NO production and iNOS expression as well as proinflammatory cytokines TNF-α and IL-6. Moreover, pretreatment with 3 and 12 could protect neurons against microglia-mediated neurotoxicity. Further, H

Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Cell Line, Transformed; Diterpenes; Gene Expression; Hydrogen Peroxide; Interleukin-6; Lipopolysaccharides; Mice; Neurites; Neuronal Outgrowth; Neuroprotection; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Oxidopamine; PC12 Cells; Rats; Receptors, Muscarinic; Tumor Necrosis Factor-alpha