ap-10 has been researched along with Osteoporosis* in 1 studies
1 other study(ies) available for ap-10 and Osteoporosis
| Article | Year |
|---|---|
Synthesis and evaluation of andrographolide derivatives as potent anti-osteoporosis agents in vitro and in vivo.
In this work, we found that 14-deoxy-11,12-didehydroandrographolide (2), a derivative of andrographolide (AP, 1), had greatly reduced cytotoxicity compared with AP and exhibited moderate anti-osteoclastogenesis activity. Thirty compounds were synthesized by introducing anti-osteoporosis chemotypes at C-19 of 2. Six of them exhibited stronger inhibition of osteoclastogenesis than AP. Of note, compound 12g displayed the most potent activity with IC Topics: Animals; Bone Resorption; Cell Differentiation; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred C57BL; Molecular Structure; Osteoclasts; Osteogenesis; Osteoporosis; RAW 264.7 Cells; Structure-Activity Relationship | 2021 |