Compounds > adimolol

Page last updated: 2024-12-06

adimolol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID Source	ID
PubMed CID	71227
CHEMBL ID	1742448
SCHEMBL ID	1254721
MeSH ID	M0131905

Synonyms (18)

Synonym
adimolol
3-[3-[(2-hydroxy-3-naphthalen-1-yloxypropyl)amino]-3-methylbutyl]-1h-benzimidazol-2-one
78459-19-5
CHEMBL1742448
(+-)-1-(3-((2-hydroxy-3-(1-naphthyloxy)propyl)amino)-3-methylbutyl)-2-benzimidazolinone
adimolol [inn]
b6cjy5k2st ,
adimololum [latin]
unii-b6cjy5k2st
adimololum
(rs)-2,3-dihydro-1-(3-(2-hydroxy-3-(naphthyloxy)propylamino)-3-methylbutyl)-1h-2-benzimidazolon
adimolol [mart.]
(+/-)-1-(3-((2-hydroxy-3-(1-naphthyloxy)propyl)amino)-3-methylbutyl)-2-benzimidazolinone
SCHEMBL1254721
Q4682859
1,3-dihydro-1-[3-[[2-hydroxy-3-(1-naphthalenyloxy)propyl]amino]-3-methylbutyl]-2h-benzimidazol-2-one
1-(3-((2-hydroxy-3-(1-naphthyloxy)propyl)amino)-3-methylbutyl)-2-benzimidazolinone
DTXSID00868480

Research Excerpts

Overview

Adimolol is a new antihypertensive agent with strong nonselective beta- and moderate alpha-adrenolytic properties.

Excerpt	Reference	Relevance
"Adimolol is a new antihypertensive agent with strong nonselective beta- and moderate alpha-adrenolytic properties. "	( Blood pressure lowering action and alpha-adrenolytic effect of adimolol in rats. Hoefke, W; Palluk, R, )	1.81

Pharmacokinetics

Excerpt	Reference	Relevance
"The pharmacokinetic properties of adimolol (MEN 935), a new antihypertensive agents with predominantly beta-receptor blocking and additional alpha-adrenolytic activity were investigated in healthy volunteers."	( Pharmacokinetics of adimolol after single and multiple dose administration in healthy volunteers. Adamus, S; Brantl, V; Justus, H; Lohmann, H; Peil, H; Wiedemann, I, 1985)	0.87

Dosage Studied

Excerpt	Relevance	Reference
" Labetalol 400 mg significantly shifted the blood pressure dose-response curve to the right."	( Comparative effects of adimolol, labetalol and propranolol on heart rate and blood pressure in man. Harron, DW; Riddell, JG; Shanks, RG, 1985)	0.58
" In addition, adimolol significantly reduced receptor number and even by 3 days after dosing Bmax had only returned to half the control value."	( Adimolol, a long acting beta-adrenoceptor blocker in man. Deighton, NM; Elliott, HL; Jones, CR; Meredith, PA; Reid, JL, 1987)	2.08

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (33.33%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (66.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
labetalol Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.. labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.. 2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.	8.35	1	1	benzamides; benzenes; phenols; primary carboxamide; salicylamides; secondary alcohol; secondary amino compound
propranolol Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.	9.32	2	2	naphthalenes; propanolamine; secondary amine	anti-arrhythmia drug; antihypertensive agent; anxiolytic drug; beta-adrenergic antagonist; environmental contaminant; human blood serum metabolite; vasodilator agent; xenobiotic
talipexole talipexole: dopamine receptor agonist; structure given in first source	1.96	1	0	azepine
phenylephrine Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.. phenylephrine : A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.	3.76	2	1	phenols; phenylethanolamines; secondary amino compound	alpha-adrenergic agonist; cardiotonic drug; mydriatic agent; nasal decongestant; protective agent; sympathomimetic agent; vasoconstrictor agent
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	6.96	1	0	amino acid zwitterion; angiotensin II	human metabolite