3-methyl-5-isoxazolecarboxylic acid: N1 same as NM; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 853085 |
| CHEMBL ID | 393428 |
| SCHEMBL ID | 222184 |
| MeSH ID | M0082475 |
| Synonym |
|---|
| HMS1695I02 |
| EN300-13477 |
| BB 0250450 |
| 4857-42-5 |
| 3-methyl-isoxazole-5-carboxylic acid |
| BAS 10142371 , |
| STK341643 |
| 3-methyl-1,2-oxazole-5-carboxylic acid |
| 5-isoxazolecarboxylic acid, 3-methyl- |
| CHEMBL393428 , |
| AKOS000302671 |
| 3-methyl-5-isoxazolecarboxylic acid |
| F2124-0612 |
| 3-methyl-5-carboxyl-isoxazole |
| 3-methylisoxazole-5-carboxylic acid |
| bdbm50211361 |
| BBL016103 |
| 5-carboxy-3-methylisoxazole |
| 5-isoxazolecarboxylicacid, 3-methyl- |
| FT-0647857 |
| AM20100200 |
| CL3463 |
| 3-methylisoxazole-5-carboxylicacid |
| SCHEMBL222184 |
| AS-5178 |
| 3-methyl-5-carboxyisoxazole |
| DS-0689 |
| AC-23153 |
| J-512915 |
| mfcd00464222 |
| CS-W005033 |
| Z90660974 |
| SY033484 |
| M2953 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | IC50 (µMol) | 1.3000 | 0.1300 | 0.3889 | 1.5000 | AID331025 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | EC50 (µMol) | 1.3000 | 0.0087 | 1.2017 | 6.3096 | AID308653 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| neutrophil apoptotic process | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| positive regulation of neutrophil apoptotic process | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| negative regulation of lipid catabolic process | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| positive regulation of adiponectin secretion | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| G protein-coupled receptor signaling pathway | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| nicotinic acid receptor activity | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| cell junction | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| plasma membrane | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID331025 | Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay | 2007 | The Journal of biological chemistry, Jun-22, Volume: 282, Issue:25 | Nicotinic acid receptor agonists differentially activate downstream effectors. |
| AID331029 | Reduction of free fatty acid level in po dosed Sprague-Dawley rat plasma | 2007 | The Journal of biological chemistry, Jun-22, Volume: 282, Issue:25 | Nicotinic acid receptor agonists differentially activate downstream effectors. |
| AID308653 | Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Agonist lead identification for the high affinity niacin receptor GPR109a. |
| AID331027 | Inhibition of isoproterenol-induced lipolysis in human subcutaneous adipocytes after 5 hrs | 2007 | The Journal of biological chemistry, Jun-22, Volume: 282, Issue:25 | Nicotinic acid receptor agonists differentially activate downstream effectors. |
| AID331030 | Reduction of free fatty acid level in po dosed Sprague-Dawley rat plasma relative to baseline | 2007 | The Journal of biological chemistry, Jun-22, Volume: 282, Issue:25 | Nicotinic acid receptor agonists differentially activate downstream effectors. |
| AID331026 | Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay relative to nicotinic acid | 2007 | The Journal of biological chemistry, Jun-22, Volume: 282, Issue:25 | Nicotinic acid receptor agonists differentially activate downstream effectors. |
| AID331031 | Induction of flushing response in ip dosed C57/BL6 mouse | 2007 | The Journal of biological chemistry, Jun-22, Volume: 282, Issue:25 | Nicotinic acid receptor agonists differentially activate downstream effectors. |
| AID331028 | Reduction of free fatty acid level in ip dosed C57/BL6 mouse plasma after 10 mins | 2007 | The Journal of biological chemistry, Jun-22, Volume: 282, Issue:25 | Nicotinic acid receptor agonists differentially activate downstream effectors. |
| AID308655 | Agonist activity at human cloned GPR109b receptor at 100 uM by forskolin-stimulated cAMP production test | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Agonist lead identification for the high affinity niacin receptor GPR109a. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.27) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||