Page last updated: 2024-12-07

2-chloro-2-phenethylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

2-chloro-2-phenethylamine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID83117
CHEMBL ID407939
SCHEMBL ID266281
MeSH IDM0149520

Synonyms (45)

Synonym
benzeneethanamine, 2-chloro-
o-chlorophenethylamine
2-(2-chlorophenyl)ethylamine, 95%
2'-chlorophenethylamine
bdbm50241030
13078-80-3
2-(2-chlorophenyl)ethylamine
2-chlorophenethylamine
1-amino-2-(2-chlorophenyl)ethane
AKOS000158359
2-(2-chlorophenyl)ethanamine
CHEMBL407939 ,
inchi=1/c8h10cln/c9-8-4-2-1-3-7(8)5-6-10/h1-4h,5-6,10h2
rzbomsohmovues-uhfffaoysa-
2-(2-chloro-phenyl)-ethylamine
o-chloro-|a-phenylethylamine
EN300-54388
einecs 235-982-1
unii-hs4bm7qje4
hs4bm7qje4 ,
2-chloro-2-phenethylamine
2-(2-chlorophenyl)ethan-1-amine
FT-0608459
SCHEMBL266281
FS-1192
[2-(2-chlorophenyl)ethyl]amine
ortho-chlorophenethylamine
2-chloro-phenethylamine
n-2-chlorobenzylmethylamine
2-(ortho-chlorophenyl)ethylamine
2-(2-chlorophenyl)-ethylamine
2-chloro-benzeneethanamine
2-chlorobenzeneethanamine
2-(2-chlorphenyl)-ethylamin
SY013460
mfcd00008185
2-(o-chlorophenyl)ethylamine
2-(2-chlorophenyl)ethanamine #
DTXSID30156741
AC-6667
J-505591
CS-W019353
3-(4-acetyl-phenyl)-2-amino-propionicacidhydrochloride
phenethylamine, o-chloro-
Z285143744
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Trace amine-associated receptor 1Homo sapiens (human)EC50 (µMol)0.07700.01501.41437.1900AID341210
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (1)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathwayTrace amine-associated receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein-coupled receptor activityTrace amine-associated receptor 1Homo sapiens (human)
trace-amine receptor activityTrace amine-associated receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneTrace amine-associated receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID262089Inhibition of DPP4 at 100 uM2006Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5
In silico fragment-based discovery of DPP-IV S1 pocket binders.
AID341210Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1.
AID341211Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay relative to 2-phenylethanamine2008Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]