2-(4'-isothiocyanatobenzyl)imidazoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(4'-isothiocyanatobenzyl)imidazoline: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	125413
CHEMBL ID	59034
MeSH ID	M0193604

Synonyms (9)

Synonym
2-ibi
CHEMBL59034
2-[(4-isothiocyanatophenyl)methyl]-4,5-dihydro-1h-imidazole
130262-94-1
2-(4'-isothiocyanatobenzyl)imidazoline
4,5-dihydro-2-((4-isothiocyanatophenyl)methyl)-1h-imidazole
1h-imidazole, 4,5-dihydro-2-((4-isothiocyanatophenyl)methyl)-
DTXSID80156433
2-(4/'-isothiocyanatobenzyl)imidazoline

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay ID	Title	Year	Journal	Article
AID196939	Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of nifedipine	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16760	Percent of maximal contractile response to compound with phenoxybenzamine pretreatment on rat thoracic aorta strips	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196935	Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 0.1 uM	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196937	Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of calcium deficient buffer	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16755	Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of calcium deficient buffer	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196943	Concentration that produces 50% of the maximal response to compound without phenoxybenzamine pretreatment on rat thoracic aorta strips	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16756	Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of nifedipine	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16757	Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of verapamil	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196932	Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196940	Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of verapamil	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16758	Percent of maximal contractile response to compound in rat thoracic aorta strips presence of PBZ and CIR	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196936	Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 1 uM	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID19939	Percent of maximal contractile response to compound in rat thoracic aorta strips	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID19943	Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 1 uM	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID19942	Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 0.1 uM	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16761	Percent of maximal contractile response to compound without phenoxybenzamine pretreatment on rat thoracic aorta strips	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196933	Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of PBZ and CIR	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196941	Concentration that produces 50% of the maximal response to compound with phenoxybenzamine pretreatment on rat thoracic aorta strips	1994	Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12	Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.50 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	1.98	1	aromatic ether; nitrile; polyether; tertiary amino compound
cirazoline cirazoline: posseses agonist properties at alpha-adrenoreceptor sites; RN given refers to parent cpd	1.98	1	aromatic ether
clonidine Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.	1.97	1	clonidine; imidazoline
nifedipine Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.	2.39	2	C-nitro compound; dihydropyridine; methyl ester	calcium channel blocker; human metabolite; tocolytic agent; vasodilator agent
oxymetazoline Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251). oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.	2	1	carboxamidine; imidazolines; phenols	alpha-adrenergic agonist; nasal decongestant; sympathomimetic agent; vasoconstrictor agent
tolazoline Tolazoline: A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.. tolazoline : A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.	3.08	5	imidazoles	alpha-adrenergic antagonist; antihypertensive agent; vasodilator agent
carbachol Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	2	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic
idazoxan Idazoxan: A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.. idazoxan : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group.	1.98	1	benzodioxine; imidazolines	alpha-adrenergic antagonist
cromakalim Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)	2	1
chlorethylclonidine chlorethylclonidine: RN refers to 2-chloroethyl derivative	1.97	1
atropine tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.	2	1
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	1.99	1
2-(2-benzofuranyl)-2-imidazoline 2-(2-benzofuranyl)-2-imidazoline: structure given in first source	1.99	1	benzofurans

Condition	Indicated	Relationship Strength	Studies	Trials
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	0	2.68	3	0

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