Compounds > 2-(4'-isothiocyanatobenzyl)imidazoline
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2-(4'-isothiocyanatobenzyl)imidazoline

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Description

2-(4'-isothiocyanatobenzyl)imidazoline: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID125413
CHEMBL ID59034
MeSH IDM0193604

Synonyms (9)

Synonym
2-ibi
CHEMBL59034
2-[(4-isothiocyanatophenyl)methyl]-4,5-dihydro-1h-imidazole
130262-94-1
2-(4'-isothiocyanatobenzyl)imidazoline
4,5-dihydro-2-((4-isothiocyanatophenyl)methyl)-1h-imidazole
1h-imidazole, 4,5-dihydro-2-((4-isothiocyanatophenyl)methyl)-
DTXSID80156433
2-(4/'-isothiocyanatobenzyl)imidazoline
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID196939Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of nifedipine1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16760Percent of maximal contractile response to compound with phenoxybenzamine pretreatment on rat thoracic aorta strips1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196935Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 0.1 uM1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196937Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of calcium deficient buffer1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16755Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of calcium deficient buffer1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196943Concentration that produces 50% of the maximal response to compound without phenoxybenzamine pretreatment on rat thoracic aorta strips1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16756Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of nifedipine1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16757Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of verapamil1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196932Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196940Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of verapamil1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16758Percent of maximal contractile response to compound in rat thoracic aorta strips presence of PBZ and CIR1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196936Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 1 uM1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID19939Percent of maximal contractile response to compound in rat thoracic aorta strips1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID19943Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 1 uM1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID19942Percent of maximal contractile response to compound in rat thoracic aorta strips in the presence of PBZ and IDA at 0.1 uM1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID16761Percent of maximal contractile response to compound without phenoxybenzamine pretreatment on rat thoracic aorta strips1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196933Concentration that produces 50% of the maximal response to compound in rat thoracic aorta strips in the presence of PBZ and CIR1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
AID196941Concentration that produces 50% of the maximal response to compound with phenoxybenzamine pretreatment on rat thoracic aorta strips1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Synthesis and biological activities of a new set of irreversibly acting 2-(4'-isothiocyanatobenzyl)imidazoline analogs in rat thoracic aorta.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9810aromatic ether;
nitrile;
polyether;
tertiary amino compound
cirazoline
cirazoline: posseses agonist properties at alpha-adrenoreceptor sites; RN given refers to parent cpd		1.9810aromatic ether
clonidine
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.		1.9710clonidine;
imidazoline
nifedipine
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.		2.3920C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
oxymetazoline
Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251). oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.		210carboxamidine;
imidazolines;
phenols		alpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
tolazoline
Tolazoline: A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.. tolazoline : A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.		3.0850imidazolesalpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent
carbachol
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.		210ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
idazoxan
Idazoxan: A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.. idazoxan : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group.		1.9810benzodioxine;
imidazolines		alpha-adrenergic antagonist
cromakalim
Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)		210
chlorethylclonidine
chlorethylclonidine: RN refers to 2-chloroethyl derivative		1.9710
atropine
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.		210
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		1.9910
2-(2-benzofuranyl)-2-imidazoline
2-(2-benzofuranyl)-2-imidazoline: structure given in first source		1.9910benzofurans
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		02.6830