10-hydroxy-8-octadecenoic acid

10-hydroxy-8-octadecenoic acid, also known as **10-HOE**, is a **hydroxy fatty acid** found naturally in plants, animals, and microbes. It is specifically a **monounsaturated fatty acid** with a hydroxyl group attached at the 10th carbon atom and a double bond at the 8th carbon atom.

**Why is 10-HOE important for research?**

10-HOE has been shown to possess various **biological activities** making it a subject of interest for research:

* **Anti-inflammatory effects:** 10-HOE has been found to suppress inflammatory responses in various cell models, potentially by inhibiting the production of pro-inflammatory cytokines. This makes it a potential therapeutic target for inflammatory diseases like arthritis and asthma.
* **Anti-cancer activity:** Studies suggest that 10-HOE may possess anti-cancer properties by inhibiting the growth and proliferation of cancer cells. This includes potential effects on leukemia, colon cancer, and breast cancer.
* **Antioxidant properties:** 10-HOE acts as an antioxidant, scavenging free radicals and protecting cells from oxidative damage. This activity could be relevant for preventing diseases associated with oxidative stress, such as cardiovascular diseases and neurodegenerative disorders.
* **Neuroprotective effects:** 10-HOE has been shown to protect neurons from damage caused by various stressors, including oxidative stress and inflammation. This suggests a potential therapeutic role for neurodegenerative conditions like Alzheimer's disease and Parkinson's disease.
* **Modulation of lipid metabolism:** 10-HOE can influence lipid metabolism, potentially impacting cholesterol levels and fatty acid synthesis. This area of research could lead to novel approaches for managing cardiovascular diseases.

**Current Research:**

Researchers are actively investigating:

* The detailed mechanisms by which 10-HOE exerts its biological activities.
* The potential of 10-HOE as a drug candidate for various diseases.
* The bioavailability and pharmacokinetics of 10-HOE in different species.
* The potential benefits and risks of using 10-HOE as a dietary supplement.

**Overall, 10-HOE is a promising molecule with diverse biological activities and therapeutic potential. Further research is needed to fully understand its mechanisms of action and translate its potential into effective treatments for various diseases.**