Page last updated: 2024-12-09
1-pyrenemethylamine
## 1-Pyrenemethylamine: A Fluorescent Probe with Research Significance
1-Pyrenemethylamine is a **fluorescent organic compound** that holds significance in various research areas.
**Structure & Properties:**
* **Structure:** It consists of a pyrene ring system (a polycyclic aromatic hydrocarbon) with a methylamine group attached at the 1-position.
* **Fluorescence:** It exhibits strong fluorescence, making it suitable for various applications.
* **Solubility:** 1-Pyrenemethylamine is soluble in organic solvents, making it suitable for studies in organic environments.
**Importance in Research:**
1-Pyrenemethylamine is widely used as a **fluorescent probe** due to its unique properties. It is particularly useful in:
* **Biophysical Studies:**
* **Lipid membrane studies:** It can be used to study the properties of lipid membranes, including fluidity, permeability, and interactions with other molecules.
* **Protein interactions:** 1-Pyrenemethylamine can be used to study the interactions between proteins and membranes, as well as protein-protein interactions.
* **DNA studies:** Its fluorescence can be utilized to investigate DNA binding and conformational changes.
* **Materials Science:**
* **Polymer characterization:** 1-Pyrenemethylamine can be incorporated into polymers to study their structure and properties.
* **Nanomaterials:** It can be used to probe the properties of various nanomaterials, including their size, shape, and surface properties.
* **Analytical Chemistry:**
* **Fluorescence microscopy:** Its fluorescence allows for imaging and visualization of various biological and material systems.
* **Sensors:** It can be used to develop sensitive and selective fluorescent sensors for various analytes.
**Advantages of Using 1-Pyrenemethylamine:**
* **High fluorescence quantum yield:** This allows for sensitive detection and analysis.
* **Distinct fluorescence properties:** Its unique fluorescence properties can be used to differentiate between various species or environments.
* **Chemical stability:** It is relatively stable, making it suitable for long-term studies.
**Overall:**
1-Pyrenemethylamine is a versatile fluorescent probe that is used in various research fields. Its ability to interact with biological systems and materials, combined with its strong fluorescence properties, makes it a valuable tool for studying complex processes and developing innovative applications.
Cross-References
ID Source | ID |
PubMed CID | 2794252 |
CHEMBL ID | 235142 |
SCHEMBL ID | 497038 |
MeSH ID | M0497938 |
Synonyms (8)
Synonym |
pyren-1-ylmethanamine |
CHEMBL235142 |
3786-54-7 |
1-pyrenemethanamine |
SCHEMBL497038 |
DTXSID90383192 |
1-pyrenemethylamine |
1-(pyren-1-yl)methanamine |
Bioassays (4)
Assay ID | Title | Year | Journal | Article |
AID304707 | Antiproliferative activity against human SKBR3 cells after 72 hrs | 2007 | Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
| Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities. |
AID304717 | Binding affinity to calf thymus DNA assessed as thermal stability in BPE buffer at 2 uM | 2007 | Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
| Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities. |
AID304719 | Binding affinity to calf thymus dodecamer DNA assessed as thermal stability in cacodylate buffer containing 0.1 M NaCl at 12 uM | 2007 | Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
| Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities. |
AID304718 | Binding affinity to calf thymus dodecamer DNA assessed as thermal stability in cacodylate buffer at 12 uM | 2007 | Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
| Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (7)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (57.14) | 29.6817 |
2010's | 3 (42.86) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 30.18
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 30.18 (24.57) | Research Supply Index | 2.08 (2.92) | Research Growth Index | 4.34 (4.65) | Search Engine Demand Index | 24.97 (26.88) | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |