Page last updated: 2024-12-09

1-pyrenemethylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1-Pyrenemethylamine: A Fluorescent Probe with Research Significance

1-Pyrenemethylamine is a **fluorescent organic compound** that holds significance in various research areas.

**Structure & Properties:**

* **Structure:** It consists of a pyrene ring system (a polycyclic aromatic hydrocarbon) with a methylamine group attached at the 1-position.
* **Fluorescence:** It exhibits strong fluorescence, making it suitable for various applications.
* **Solubility:** 1-Pyrenemethylamine is soluble in organic solvents, making it suitable for studies in organic environments.

**Importance in Research:**

1-Pyrenemethylamine is widely used as a **fluorescent probe** due to its unique properties. It is particularly useful in:

* **Biophysical Studies:**
* **Lipid membrane studies:** It can be used to study the properties of lipid membranes, including fluidity, permeability, and interactions with other molecules.
* **Protein interactions:** 1-Pyrenemethylamine can be used to study the interactions between proteins and membranes, as well as protein-protein interactions.
* **DNA studies:** Its fluorescence can be utilized to investigate DNA binding and conformational changes.
* **Materials Science:**
* **Polymer characterization:** 1-Pyrenemethylamine can be incorporated into polymers to study their structure and properties.
* **Nanomaterials:** It can be used to probe the properties of various nanomaterials, including their size, shape, and surface properties.
* **Analytical Chemistry:**
* **Fluorescence microscopy:** Its fluorescence allows for imaging and visualization of various biological and material systems.
* **Sensors:** It can be used to develop sensitive and selective fluorescent sensors for various analytes.

**Advantages of Using 1-Pyrenemethylamine:**

* **High fluorescence quantum yield:** This allows for sensitive detection and analysis.
* **Distinct fluorescence properties:** Its unique fluorescence properties can be used to differentiate between various species or environments.
* **Chemical stability:** It is relatively stable, making it suitable for long-term studies.

**Overall:**

1-Pyrenemethylamine is a versatile fluorescent probe that is used in various research fields. Its ability to interact with biological systems and materials, combined with its strong fluorescence properties, makes it a valuable tool for studying complex processes and developing innovative applications.

Cross-References

ID SourceID
PubMed CID2794252
CHEMBL ID235142
SCHEMBL ID497038
MeSH IDM0497938

Synonyms (8)

Synonym
pyren-1-ylmethanamine
CHEMBL235142
3786-54-7
1-pyrenemethanamine
SCHEMBL497038
DTXSID90383192
1-pyrenemethylamine
1-(pyren-1-yl)methanamine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID304707Antiproliferative activity against human SKBR3 cells after 72 hrs2007Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities.
AID304717Binding affinity to calf thymus DNA assessed as thermal stability in BPE buffer at 2 uM2007Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities.
AID304719Binding affinity to calf thymus dodecamer DNA assessed as thermal stability in cacodylate buffer containing 0.1 M NaCl at 12 uM2007Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities.
AID304718Binding affinity to calf thymus dodecamer DNA assessed as thermal stability in cacodylate buffer at 12 uM2007Journal of medicinal chemistry, Dec-27, Volume: 50, Issue:26
Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.18 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index24.97 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]