Page last updated: 2024-12-11
1-butyl oleate
Description
## 1-Butyl oleate: A Versatile Tool in Research
1-Butyl oleate is an **ester** formed from the reaction of oleic acid and butanol. It's a clear, colorless liquid with a mild odor, and is **biocompatible**, meaning it doesn't cause harmful reactions in living organisms. This makes it useful in a wide range of research applications.
**Here are some key areas where 1-butyl oleate is important:**
**1. Drug Delivery:**
* **Liposomes:** 1-butyl oleate is a common component in liposomes, which are tiny spheres that encapsulate drugs. It helps stabilize the liposome structure and enhances its ability to deliver drugs to specific cells.
* **Nanoparticles:** 1-butyl oleate can also be used in the formation of nanoparticles for drug delivery. Its biocompatibility and ability to improve drug solubility make it ideal for this purpose.
**2. Cosmetics and Personal Care:**
* **Emulsifier:** 1-butyl oleate acts as an emulsifier, helping to blend oil and water-based ingredients in cosmetics. It also provides moisturizing and skin-softening properties.
* **Skin Penetration Enhancer:** 1-butyl oleate can enhance the penetration of active ingredients through the skin, leading to improved efficacy of topical products.
**3. Food Industry:**
* **Food Additive:** 1-butyl oleate is used as a food additive to improve texture, flavor, and shelf life of various food products.
* **Antioxidant:** Its antioxidant properties help prevent oxidation and rancidity in food products.
**4. Industrial Applications:**
* **Lubricant:** 1-butyl oleate can be used as a lubricant due to its low viscosity and excellent lubricating properties.
* **Biodiesel:** 1-butyl oleate is also being investigated as a potential biofuel.
**In summary, 1-butyl oleate is a versatile compound with numerous applications in research and industry. Its biocompatibility, emulsification properties, and potential to enhance drug delivery make it a valuable tool for scientists and researchers across various disciplines.**
**Important Note:** While 1-butyl oleate is generally considered safe, further research is always necessary to ensure its safety and efficacy in specific applications.
1-butyl oleate: produced by direct esterification of butanol and oleic acid to decrease the viscosity of biodiesel in winter use [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
n-butyl oleate : A fatty acid ester obtained by the formal condensation of the hydroxy group of butan-1-ol with the carboxy group of oleic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
Synonyms (72)
| Synonym |
|---|
| kessco 554 |
| wilmar butyl oleate |
| nsc-6700 |
| kesscoflex bo |
| nsc6700 |
| witcizer 101 |
| hallco c-503 plasticizer |
| witcizer 100 |
| advaplast 42 |
| 9-octadecenoic acid (z)-, butyl ester |
| oleic acid, butyl ester |
| butyl oleate |
| 142-77-8 |
| (e)-9-octadecenoic acid butyl ester |
| elaidic acid, butyl ester |
| 9-octadecenoic acid (9z)-, butyl ester |
| butyl (9z)-octadec-9-enoate |
| n-butyl oleate |
| brn 1728057 |
| plasthall 503 |
| vinicizer 30 |
| einecs 205-559-6 |
| plasthall 914 |
| ai3-00660 |
| hsdb 5483 |
| butyl 9-octadecenoate |
| uniflex byo |
| 9-octadecenoic acid, butyl ester (cis) |
| bytyl oleate |
| butyl cis-9-octadecenoate |
| nsc 6700 |
| 9-octadecenoic acid, butyl ester (z)- |
| advaplast 42 (van) |
| hallco c 503 |
| 9-octadecenoic acid, butyl ester |
| (z)-9-octadecenoic acid butyl ester |
| oleic acid butyl ester |
| butyl (z)-octadec-9-enoate |
| 4-02-00-01653 (beilstein handbook reference) |
| 1-butyl oleate |
| 487i65419q , |
| unii-487i65419q |
| butyloleate |
| dtxsid7027099 , |
| tox21_202744 |
| NCGC00260292-01 |
| dtxcid007099 |
| cas-142-77-8 |
| oleic acid n-butyl ester |
| aec butyl oleate |
| oleic acid, butyl ester [hsdb] |
| butyl oleate [inci] |
| SCHEMBL79292 |
| CHEBI:82946 , |
| AKOS024386323 |
| butyl 9-octadecenoate or 9-18:1 |
| WIBFFTLQMKKBLZ-SEYXRHQNSA-N |
| (z)-octadec-9-enoic acid butyl ester |
| CHEMBL3183174 |
| LMFA07010975 |
| mfcd00053819 |
| J-007695 |
| oleate, butyl ester |
| n-butyl oleic acid |
| butyl oleic acid |
| 1-butyl oleic acid |
| butyl 9-octadecenoic acid |
| Q27156481 |
| butyl (z)-9-octadecenoate |
| AS-13009 |
| CS-0185614 |
| HY-W127377 |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|
| " Full-cell catalysis temperature and the cell dosage rate on oleate production were evaluated and optimized in the esterification process." | ( Simultaneous acetone-butanol-ethanol fermentation, gas stripping, and full-cell-catalyzed esterification for effective production of butyl oleate.
Cai, D; Cai, J; Chen, B; Chen, C; Chen, H; Qin, P; Sun, G; Tan, T; Zhen, Y, 2018) | 0.48 |
| " The yield of butyl oleate was impacted by the dosage and distribution of M-CLEAs in micro-reactor." | ( Synthesis of butyl oleate catalyzed by cross-linked enzyme aggregates with magnetic nanoparticles in rotating magneto-micro-reactor.
Diao, X; Lin, J; Qiu, S; Wang, S; Zheng, D, 2018) | 0.48 |
Roles (1)
| Role | Description |
|---|
| human metabolite | Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (1)
| Class | Description |
|---|
| fatty acid ester | A carboxylic ester in which the carboxylic acid component can be any fatty acid. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein Targets (4)
Potency Measurements
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.66
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.66 (24.57) | | Research Supply Index | 2.20 (2.92) | | Research Growth Index | 4.86 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |