biotin and methotrexate
biotin has been researched along with methotrexate in 27 studies
Compound Research Comparison
| Studies (biotin) | Trials (biotin) | Recent Studies (post-2010) (biotin) | Studies (methotrexate) | Trials (methotrexate) | Recent Studies (post-2010) (methotrexate) |
|---|---|---|---|---|---|
| 14,847 | 95 | 3,882 | 41,593 | 5,666 | 11,969 |
Protein Interaction Comparison
| Protein | Taxonomy | biotin (IC50) | methotrexate (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 1.8 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 0.211 | |
| Toll-like receptor 4 | Homo sapiens (human) | 1.04 | |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | 0.08 | |
| Dihydrofolate reductase | Homo sapiens (human) | 0.0522 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0331 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.0348 | |
| Dihydrofolate reductase | Gallus gallus (chicken) | 0.0545 | |
| Dihydrofolate reductase | Enterococcus faecium | 0.0014 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.0138 | |
| Thymidylate synthase | Homo sapiens (human) | 0.343 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0147 | |
| Thymidylate synthase | Escherichia coli K-12 | 0.0181 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.1529 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.084 | |
| Folate receptor beta | Homo sapiens (human) | 0.1585 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0011 | |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | 0.0012 | |
| Folate receptor alpha | Homo sapiens (human) | 0.2263 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.0717 | |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | 0.0014 | |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.01 | |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.01 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Reduced folate transporter | Homo sapiens (human) | 0.012 | |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | 0.0174 | |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | 3.2 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.0547 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | 0.11 | |
| Dihydrofolate reductase | Bacillus anthracis | 0.0136 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 0.0047 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.1207 |
Research
Studies (27)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bigland, CH; Warenycia, MW | 1 |
| Fan, J; Huennekens, FM; Vitols, KS | 2 |
| Henderson, GB; Kumar, HP; Tsuji, JM | 1 |
| Hashimoto, K; Kinsky, SC; Loader, JE | 1 |
| Basi, GS; Earnshaw, WC; Eischen, CM; Kaufmann, SH; Kottke, TJ; Leibson, PJ; Martins, LM; Tung, JS | 1 |
| Fan, J; Huennekens, FM | 1 |
| Ito, Y | 1 |
| Arthurs, S; Bouzida, D; Colson, AB; Freer, ST; Gehlhaar, DK; Larson, V; Luty, BA; Rejto, PA; Rose, PW; Verkhivker, GM | 1 |
| Jain, NK; Mishra, PR | 1 |
| Benkovic, SJ; Dwyer, M; Hammes, GG; McCourt, L; Rajagopalan, PT; Zhang, Z | 1 |
| Flintoff, WF; Sadlish, H; Williams, FM | 1 |
| Garfield, S; Gottesman, MM; Liang, XJ; Shen, DW | 1 |
| Bret, G; Kellenberger, E; Müller, P; Paul, N; Rognan, D | 1 |
| Cheng, C; Cheng, SX; Wei, H; Zhang, XZ; Zhuo, RX | 1 |
| Atyabi, F; Borougeni, AT; Dinarvand, R; Khorramizadeh, MR; Mansoori, P; Nouri, FS; Taheri, A | 1 |
| Ahadi, F; Atyabi, F; Borougeni, AT; Dinarvand, R; Ghahremani, MH; Mansoori, P; Nouri, F; Ostad, SN; Taheri, A | 1 |
| Davenport, KR; Hofstetter, H; Hofstetter, O; Horn, JR; Smith, CA | 1 |
| Nakamura, H; Sato, S; Tsushima, M | 1 |
| Gothelf, KV; Hansen-Bruhn, M; Nielsen, LDF | 1 |
| Cavallaro, G; García-Villén, F; Lazzara, G; Massaro, M; Muratore, N; Notarbartolo, M; Poma, P; Riela, S; Sánchez-Espejo, R; Viseras Iborra, C | 1 |
| Abedi, M; Javanmardi, S; Mohammad Tamaddon, A; Mohebi, Y; Najafi, H; Sadat Abolmaali, S; Zarenejad, S | 1 |
| Fu, TY; Huang, SJ; Lin, FL; Tan, KT; Wang, XY; Wu, CC | 1 |
Other Studies
27 other study(ies) available for biotin and methotrexate
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Effects of biotin, folic acid, and pantothenic acid on the growth of Mycoplasma meleagridis, a turkey pathogen.
Topics: Aminopterin; Avidin; Biotin; Culture Media; Folic Acid; Methotrexate; Mycoplasma; Pantothenic Acid | 1978 |
Multiple folate transport systems in L1210 cells.
Topics: Animals; Biotin; Carrier Proteins; Chromatography, Affinity; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured | 1992 |
Biotin derivatives of methotrexate and folate. Synthesis and utilization for affinity purification of two membrane-associated folate transporters from L1210 cells.
Topics: Animals; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured | 1991 |
Folate transport in Lactobacillus salivarius. Characterization of the transport mechanism and purification and properties of the binding component.
Topics: Biological Transport; Biotin; Carrier Proteins; Cell Membrane; Chromatography; Folate Receptors, GPI-Anchored; Folic Acid; Glucose; Glutamine; Kinetics; Lactobacillus; Methotrexate; Molecular Weight; Receptors, Cell Surface; Thiamine | 1987 |
Iodoacetylated and biotinylated liposomes: effect of spacer length on sulfhydryl ligand binding and avidin precipitability.
Topics: Avidin; Biotin; Chemical Precipitation; Immunoglobulin G; Iodoacetates; Iodoacetic Acid; Ligands; Liposomes; Methotrexate; Ovalbumin; Phosphatidylethanolamines; Structure-Activity Relationship; Sulfhydryl Compounds | 1986 |
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
Topics: Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Camptothecin; Caspase 3; Caspase 7; Caspases; Cisplatin; Cysteine Endopeptidases; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lamin Type B; Lamins; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured | 1997 |
Biotin derivatives of folate compounds: synthesis and utilization for visualization and affinity purification of folate transport proteins.
Topics: Animals; Bacterial Proteins; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Fluorescein; Fluoresceins; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Microscopy; Molecular Structure; Receptors, Cell Surface; Sepharose; Tumor Cells, Cultured | 1997 |
Analytical application of host-guest chemistry using in vitro selection.
Topics: Antibodies; Base Sequence; Biological Assay; Biotin; DNA; Fluorescent Dyes; Folic Acid; Methotrexate; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Thyroxine | 1997 |
Thermodynamics and kinetics of ligand-protein binding studied with the weighted histogram analysis method and simulated annealing.
Topics: Biotin; Computer Simulation; Kinetics; Ligands; Methotrexate; Models, Chemical; Monte Carlo Method; Protein Binding; Proteins; Software; Streptavidin; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics | 1999 |
Biotinylated methotrexate loaded erythrocytes for enhanced liver uptake. 'A study on the rat'.
Topics: Animals; Avidin; Biotin; Drug Carriers; Enzyme Inhibitors; Erythrocytes; Esters; Liver; Macrophages; Methotrexate; Rats; Succinimides | 2002 |
Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.
Topics: Base Sequence; Biotin; DNA, Bacterial; Escherichia coli; Fluorescent Dyes; Genes, Bacterial; Kinetics; Methotrexate; Microscopy, Fluorescence; Models, Molecular; Mutation; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2002 |
The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.
Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Biotin; Biotinylation; Carrier Proteins; Cell Membrane; Cricetinae; Cysteine; Cytosol; Folic Acid; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reduced Folate Carrier Protein; RNA; Streptolysins | 2003 |
Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotin; Carbon Radioisotopes; Carboplatin; Carrier Proteins; Cell Membrane; Cisplatin; Cysteine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; KB Cells; Lysosomes; Methionine; Methotrexate; Receptors, Cell Surface; Succinimides; Sulfur Radioisotopes; Triiodobenzoic Acids; Tritium | 2003 |
Recovering the true targets of specific ligands by virtual screening of the protein data bank.
Topics: Algorithms; Amino Acid Sequence; Binding Sites; Biotin; Computational Biology; Computer Simulation; Crystallography, X-Ray; Databases, Protein; Drug Evaluation, Preclinical; Ligands; Methotrexate; Molecular Sequence Data; Molecular Weight; Proteins; Purine Nucleosides; Ribonucleosides; Sensitivity and Specificity; Software; Substrate Specificity; Tamoxifen | 2004 |
Thermo-triggered and biotinylated biotin-P(NIPAAm-co-HMAAm)-b-PMMA micelles for controlled drug release.
Topics: Acrylic Resins; Biotin; Drug Carriers; Magnetic Resonance Spectroscopy; Methotrexate; Micelles; Microscopy, Electron, Transmission; Molecular Structure; Particle Size; Polymethyl Methacrylate; Solutions; Spectroscopy, Fourier Transform Infrared; Temperature | 2009 |
Use of biotin targeted methotrexate-human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy.
Topics: Animals; Antineoplastic Agents; Biotin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Nanoconjugates; Nanomedicine; Serum Albumin | 2011 |
Targeted delivery of methotrexate to tumor cells using biotin functionalized methotrexate-human serum albumin conjugated nanoparticles.
Topics: Antineoplastic Agents; Biotin; Cell Survival; Drug Stability; Flow Cytometry; Fluorescein-5-isothiocyanate; HeLa Cells; Humans; Inhibitory Concentration 50; Methotrexate; Microscopy, Fluorescence; Nanoconjugates; Particle Size; Serum Albumin | 2011 |
Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns.
Topics: Animals; Antibodies, Immobilized; Biotin; Camelus; Chromatography, Affinity; Limit of Detection; Linear Models; Methotrexate; Reproducibility of Results | 2016 |
Selective purification and chemical labeling of a target protein on ruthenium photocatalyst-functionalized affinity beads.
Topics: Benzenesulfonamides; Biotin; Catalysis; Free Radicals; HeLa Cells; Humans; Methotrexate; Organometallic Compounds; Photochemical Processes; Ruthenium; Sulfonamides; Surface Properties; Tetrahydrofolate Dehydrogenase; Tyrosine | 2017 |
Rapid Detection of Drugs in Human Plasma Using a Small-Molecule-Linked Hybridization Chain Reaction.
Topics: Antibodies; Biotin; Carbocyanines; Digoxigenin; Digoxin; DNA, Complementary; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Limit of Detection; Methotrexate; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Point-of-Care Testing; Streptavidin | 2018 |
Prodrug based on halloysite delivery systems to improve the antitumor ability of methotrexate in leukemia cell lines.
Topics: Antineoplastic Agents; Biotin; Cell Line; Clay; Humans; Leukemia; Methotrexate; Nanotubes; Prodrugs; Spectroscopy, Fourier Transform Infrared | 2022 |
Biotin receptor-targeting nanogels loaded with methotrexate for enhanced antitumor efficacy in triple-negative breast cancer in vitro and in vivo models.
Topics: Animals; Biotin; Drug Carriers; Drug Delivery Systems; Humans; Methotrexate; Mice; Nanogels; Receptors, Growth Factor; Triple Negative Breast Neoplasms | 2022 |
Small-Molecule Modulated Affinity-Tunable Semisynthetic Protein Switches.
Topics: Biotin; Fluorescent Dyes; Methotrexate; Nucleic Acids; Proteins; Streptavidin; Sulfonamides; Trimethoprim | 2022 |