Page last updated: 2024-09-05

biotin and methotrexate

biotin has been researched along with methotrexate in 27 studies

Compound Research Comparison

Studies
(biotin)
Trials
(biotin)
Recent Studies (post-2010)
(biotin)
Studies
(methotrexate)
Trials
(methotrexate)
Recent Studies (post-2010) (methotrexate)
14,847953,88241,5935,66611,969

Protein Interaction Comparison

ProteinTaxonomybiotin (IC50)methotrexate (IC50)
Thymidylate synthase Escherichia coli1.8
nuclear receptor coactivator 3 isoform aHomo sapiens (human)0.211
Toll-like receptor 4Homo sapiens (human)1.04
Fatty-acid amide hydrolase 1Mus musculus (house mouse)0.08
Dihydrofolate reductaseHomo sapiens (human)0.0522
Dihydrofolate reductaseMus musculus (house mouse)0.0331
Dihydrofolate reductase Bos taurus (cattle)0.0348
Dihydrofolate reductaseGallus gallus (chicken)0.0545
Dihydrofolate reductaseEnterococcus faecium0.0014
Dihydrofolate reductaseLacticaseibacillus casei0.0138
Thymidylate synthaseHomo sapiens (human)0.343
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0147
Thymidylate synthaseEscherichia coli K-120.0181
Dihydrofolate reductaseEscherichia coli K-120.1529
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K10.084
Folate receptor betaHomo sapiens (human)0.1585
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0011
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)0.0012
Folate receptor alphaHomo sapiens (human)0.2263
Dihydrofolate reductasePneumocystis carinii0.0717
Histidine decarboxylaseRattus norvegicus (Norway rat)0.0014
Trifunctional purine biosynthetic protein adenosine-3Homo sapiens (human)0.01
Bifunctional purine biosynthesis protein ATICHomo sapiens (human)0.01
Delta-type opioid receptorRattus norvegicus (Norway rat)0.003
Mu-type opioid receptorRattus norvegicus (Norway rat)0.003
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.003
Reduced folate transporterHomo sapiens (human)0.012
Dihydrofolate reductaseMycobacterium tuberculosis H37Rv0.0174
Folylpolyglutamate synthase, mitochondrialHomo sapiens (human)3.2
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii0.0547
Bifunctional dihydrofolate reductase-thymidylate synthaseTrypanosoma cruzi0.11
Dihydrofolate reductase Bacillus anthracis0.0136
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.0047
Proton-coupled folate transporterHomo sapiens (human)0.1207

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.81)18.7374
1990's6 (22.22)18.2507
2000's6 (22.22)29.6817
2010's8 (29.63)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
Andrews, PR; Craik, DJ; Martin, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Bigland, CH; Warenycia, MW1
Fan, J; Huennekens, FM; Vitols, KS2
Henderson, GB; Kumar, HP; Tsuji, JM1
Hashimoto, K; Kinsky, SC; Loader, JE1
Basi, GS; Earnshaw, WC; Eischen, CM; Kaufmann, SH; Kottke, TJ; Leibson, PJ; Martins, LM; Tung, JS1
Fan, J; Huennekens, FM1
Ito, Y1
Arthurs, S; Bouzida, D; Colson, AB; Freer, ST; Gehlhaar, DK; Larson, V; Luty, BA; Rejto, PA; Rose, PW; Verkhivker, GM1
Jain, NK; Mishra, PR1
Benkovic, SJ; Dwyer, M; Hammes, GG; McCourt, L; Rajagopalan, PT; Zhang, Z1
Flintoff, WF; Sadlish, H; Williams, FM1
Garfield, S; Gottesman, MM; Liang, XJ; Shen, DW1
Bret, G; Kellenberger, E; Müller, P; Paul, N; Rognan, D1
Cheng, C; Cheng, SX; Wei, H; Zhang, XZ; Zhuo, RX1
Atyabi, F; Borougeni, AT; Dinarvand, R; Khorramizadeh, MR; Mansoori, P; Nouri, FS; Taheri, A1
Ahadi, F; Atyabi, F; Borougeni, AT; Dinarvand, R; Ghahremani, MH; Mansoori, P; Nouri, F; Ostad, SN; Taheri, A1
Davenport, KR; Hofstetter, H; Hofstetter, O; Horn, JR; Smith, CA1
Nakamura, H; Sato, S; Tsushima, M1
Gothelf, KV; Hansen-Bruhn, M; Nielsen, LDF1
Cavallaro, G; García-Villén, F; Lazzara, G; Massaro, M; Muratore, N; Notarbartolo, M; Poma, P; Riela, S; Sánchez-Espejo, R; Viseras Iborra, C1
Abedi, M; Javanmardi, S; Mohammad Tamaddon, A; Mohebi, Y; Najafi, H; Sadat Abolmaali, S; Zarenejad, S1
Fu, TY; Huang, SJ; Lin, FL; Tan, KT; Wang, XY; Wu, CC1

Other Studies

27 other study(ies) available for biotin and methotrexate

ArticleYear
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Effects of biotin, folic acid, and pantothenic acid on the growth of Mycoplasma meleagridis, a turkey pathogen.
    Poultry science, 1978, Volume: 57, Issue:3

    Topics: Aminopterin; Avidin; Biotin; Culture Media; Folic Acid; Methotrexate; Mycoplasma; Pantothenic Acid

1978
Multiple folate transport systems in L1210 cells.
    Advances in enzyme regulation, 1992, Volume: 32

    Topics: Animals; Biotin; Carrier Proteins; Chromatography, Affinity; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured

1992
Biotin derivatives of methotrexate and folate. Synthesis and utilization for affinity purification of two membrane-associated folate transporters from L1210 cells.
    The Journal of biological chemistry, 1991, Aug-15, Volume: 266, Issue:23

    Topics: Animals; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured

1991
Folate transport in Lactobacillus salivarius. Characterization of the transport mechanism and purification and properties of the binding component.
    The Journal of biological chemistry, 1987, May-25, Volume: 262, Issue:15

    Topics: Biological Transport; Biotin; Carrier Proteins; Cell Membrane; Chromatography; Folate Receptors, GPI-Anchored; Folic Acid; Glucose; Glutamine; Kinetics; Lactobacillus; Methotrexate; Molecular Weight; Receptors, Cell Surface; Thiamine

1987
Iodoacetylated and biotinylated liposomes: effect of spacer length on sulfhydryl ligand binding and avidin precipitability.
    Biochimica et biophysica acta, 1986, Apr-25, Volume: 856, Issue:3

    Topics: Avidin; Biotin; Chemical Precipitation; Immunoglobulin G; Iodoacetates; Iodoacetic Acid; Ligands; Liposomes; Methotrexate; Ovalbumin; Phosphatidylethanolamines; Structure-Activity Relationship; Sulfhydryl Compounds

1986
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
    Blood, 1997, Aug-01, Volume: 90, Issue:3

    Topics: Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Biotin; Camptothecin; Caspase 3; Caspase 7; Caspases; Cisplatin; Cysteine Endopeptidases; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lamin Type B; Lamins; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Nuclear Proteins; Oligopeptides; Poly(ADP-ribose) Polymerases; Staurosporine; Topoisomerase II Inhibitors; Topotecan; Tumor Cells, Cultured

1997
Biotin derivatives of folate compounds: synthesis and utilization for visualization and affinity purification of folate transport proteins.
    Methods in enzymology, 1997, Volume: 281

    Topics: Animals; Bacterial Proteins; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Fluorescein; Fluoresceins; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Microscopy; Molecular Structure; Receptors, Cell Surface; Sepharose; Tumor Cells, Cultured

1997
Analytical application of host-guest chemistry using in vitro selection.
    Nucleic acids symposium series, 1997, Issue:37

    Topics: Antibodies; Base Sequence; Biological Assay; Biotin; DNA; Fluorescent Dyes; Folic Acid; Methotrexate; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Thyroxine

1997
Thermodynamics and kinetics of ligand-protein binding studied with the weighted histogram analysis method and simulated annealing.
    Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 1999

    Topics: Biotin; Computer Simulation; Kinetics; Ligands; Methotrexate; Models, Chemical; Monte Carlo Method; Protein Binding; Proteins; Software; Streptavidin; Temperature; Tetrahydrofolate Dehydrogenase; Thermodynamics

1999
Biotinylated methotrexate loaded erythrocytes for enhanced liver uptake. 'A study on the rat'.
    International journal of pharmaceutics, 2002, Jan-14, Volume: 231, Issue:2

    Topics: Animals; Avidin; Biotin; Drug Carriers; Enzyme Inhibitors; Erythrocytes; Esters; Liver; Macrophages; Methotrexate; Rats; Succinimides

2002
Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Oct-15, Volume: 99, Issue:21

    Topics: Base Sequence; Biotin; DNA, Bacterial; Escherichia coli; Fluorescent Dyes; Genes, Bacterial; Kinetics; Methotrexate; Microscopy, Fluorescence; Models, Molecular; Mutation; Protein Conformation; Tetrahydrofolate Dehydrogenase; Thermodynamics

2002
The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.
    The Journal of biological chemistry, 2003, Oct-17, Volume: 278, Issue:42

    Topics: Alanine; Amino Acid Sequence; Animals; Bacterial Proteins; Biotin; Biotinylation; Carrier Proteins; Cell Membrane; Cricetinae; Cysteine; Cytosol; Folic Acid; Green Fluorescent Proteins; Kinetics; Luminescent Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Reduced Folate Carrier Protein; RNA; Streptolysins

2003
Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines.
    Cancer research, 2003, Sep-15, Volume: 63, Issue:18

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotin; Carbon Radioisotopes; Carboplatin; Carrier Proteins; Cell Membrane; Cisplatin; Cysteine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; KB Cells; Lysosomes; Methionine; Methotrexate; Receptors, Cell Surface; Succinimides; Sulfur Radioisotopes; Triiodobenzoic Acids; Tritium

2003
Recovering the true targets of specific ligands by virtual screening of the protein data bank.
    Proteins, 2004, Mar-01, Volume: 54, Issue:4

    Topics: Algorithms; Amino Acid Sequence; Binding Sites; Biotin; Computational Biology; Computer Simulation; Crystallography, X-Ray; Databases, Protein; Drug Evaluation, Preclinical; Ligands; Methotrexate; Molecular Sequence Data; Molecular Weight; Proteins; Purine Nucleosides; Ribonucleosides; Sensitivity and Specificity; Software; Substrate Specificity; Tamoxifen

2004
Thermo-triggered and biotinylated biotin-P(NIPAAm-co-HMAAm)-b-PMMA micelles for controlled drug release.
    Journal of biomedical materials research. Part A, 2009, Mar-01, Volume: 88, Issue:3

    Topics: Acrylic Resins; Biotin; Drug Carriers; Magnetic Resonance Spectroscopy; Methotrexate; Micelles; Microscopy, Electron, Transmission; Molecular Structure; Particle Size; Polymethyl Methacrylate; Solutions; Spectroscopy, Fourier Transform Infrared; Temperature

2009
Use of biotin targeted methotrexate-human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy.
    International journal of nanomedicine, 2011, Volume: 6

    Topics: Animals; Antineoplastic Agents; Biotin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred BALB C; Nanoconjugates; Nanomedicine; Serum Albumin

2011
Targeted delivery of methotrexate to tumor cells using biotin functionalized methotrexate-human serum albumin conjugated nanoparticles.
    Journal of biomedical nanotechnology, 2011, Volume: 7, Issue:6

    Topics: Antineoplastic Agents; Biotin; Cell Survival; Drug Stability; Flow Cytometry; Fluorescein-5-isothiocyanate; HeLa Cells; Humans; Inhibitory Concentration 50; Methotrexate; Microscopy, Fluorescence; Nanoconjugates; Particle Size; Serum Albumin

2011
Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, May-15, Volume: 1021

    Topics: Animals; Antibodies, Immobilized; Biotin; Camelus; Chromatography, Affinity; Limit of Detection; Linear Models; Methotrexate; Reproducibility of Results

2016
Selective purification and chemical labeling of a target protein on ruthenium photocatalyst-functionalized affinity beads.
    Chemical communications (Cambridge, England), 2017, Apr-27, Volume: 53, Issue:35

    Topics: Benzenesulfonamides; Biotin; Catalysis; Free Radicals; HeLa Cells; Humans; Methotrexate; Organometallic Compounds; Photochemical Processes; Ruthenium; Sulfonamides; Surface Properties; Tetrahydrofolate Dehydrogenase; Tyrosine

2017
Rapid Detection of Drugs in Human Plasma Using a Small-Molecule-Linked Hybridization Chain Reaction.
    ACS sensors, 2018, 09-28, Volume: 3, Issue:9

    Topics: Antibodies; Biotin; Carbocyanines; Digoxigenin; Digoxin; DNA, Complementary; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Limit of Detection; Methotrexate; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Point-of-Care Testing; Streptavidin

2018
Prodrug based on halloysite delivery systems to improve the antitumor ability of methotrexate in leukemia cell lines.
    Colloids and surfaces. B, Biointerfaces, 2022, Volume: 213

    Topics: Antineoplastic Agents; Biotin; Cell Line; Clay; Humans; Leukemia; Methotrexate; Nanotubes; Prodrugs; Spectroscopy, Fourier Transform Infrared

2022
Biotin receptor-targeting nanogels loaded with methotrexate for enhanced antitumor efficacy in triple-negative breast cancer in vitro and in vivo models.
    International journal of pharmaceutics, 2022, Aug-25, Volume: 624

    Topics: Animals; Biotin; Drug Carriers; Drug Delivery Systems; Humans; Methotrexate; Mice; Nanogels; Receptors, Growth Factor; Triple Negative Breast Neoplasms

2022
Small-Molecule Modulated Affinity-Tunable Semisynthetic Protein Switches.
    ACS sensors, 2022, 09-23, Volume: 7, Issue:9

    Topics: Biotin; Fluorescent Dyes; Methotrexate; Nucleic Acids; Proteins; Streptavidin; Sulfonamides; Trimethoprim

2022