wz-811 and Edema

wz-811 has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for wz-811 and Edema

ArticleYear
Synthesis and evaluation of 2,5-diamino and 2,5-dianilinomethyl pyridine analogues as potential CXCR4 antagonists.
    Bioorganic & medicinal chemistry letters, 2019, 01-15, Volume: 29, Issue:2

    CXCR4 and its cognate ligand CXCL12 has been linked to various pathways such as cancer metastasis, inflammation, HIV-1 proliferation, and auto-immune diseases. Small molecules have shown potential as CXCR4 inhibitors and modulators, and therefore can mitigate diseases related to the CXCR4-CXCL12 pathway. We have designed and synthesized a series of 2,5-diamino and 2,5-dianilinomethyl pyridine derivatives as potential CXCR4 antagonists. Thirteen compounds have an effective concentration (EC) of 100 nM or less in a binding affinity assay and nine of these have at least 75% inhibition of invasion in Matrigel binding assay. Compounds 3l, 7f, 7j, and 7p show a minimal reduction in inflammation when carrageenan paw edema test is conducted. Overall, these compounds show potential as CXCR4 antagonist.

    Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Drug Design; Edema; Humans; Inflammation; Mice; Molecular Structure; Pyridines; Receptors, CXCR4; Structure-Activity Relationship

2019