Compounds > verazine
Page last updated: 2024-12-08

verazine

Description

verazine: from Veratrum nigrum [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Veratrum nigrumspecies[no description available]MelanthiaceaeA family in the order Liliales, of bulbous or rhizomatous woodland and alpine perennial herbs.[MeSH]

Cross-References

ID SourceID
PubMed CID161052
CHEMBL ID457588
SCHEMBL ID14052452
MeSH IDM0150213

Synonyms (10)

Synonym
verazine
14320-81-1
CHEMBL457588
(3s,8s,9s,10r,13s,14s,17r)-10,13-dimethyl-17-[(1s)-1-[(3s)-3-methyl-2,3,4,5-tetrahydropyridin-6-yl]ethyl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol
16,28-secosolanida-5,22(28)-dien-3-ol, (3beta)-
SCHEMBL14052452
DTXSID70931776
20-(5-methyl-3,4,5,6-tetrahydropyridin-2-yl)pregn-5-en-3-ol
HY-N11911
CS-0889764
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID402396Antifungal activity against Saccharomyces cerevisiae 13531998Journal of natural products, Oct, Volume: 61, Issue:10
DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1.
AID1763408Binding affinity to recombinant human Flag-6 x His-tagged Smo expressed in human HEK293T cells assessed as reduction in BODIPY-Cyclopamine binding by measuring fluorescence intensity incubated for 2 to 4 hrs by fluorescence microscopic based competitive b2021Bioorganic & medicinal chemistry, 06-01, Volume: 39Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.
AID402397Antifungal activity against Saccharomyces cerevisiae Sc71998Journal of natural products, Oct, Volume: 61, Issue:10
DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1.
AID402395Antifungal activity against Saccharomyces cerevisiae 11401998Journal of natural products, Oct, Volume: 61, Issue:10
DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1.
AID1763409Binding affinity to recombinant human Flag-6 x His-tagged Smo expressed in human HEK293T cells assessed as reduction in BODIPY-Cyclopamine binding by measuring fluorescence intensity at 30 uM incubated for 2 to 4 hrs by fluorescence microscopic competitiv2021Bioorganic & medicinal chemistry, 06-01, Volume: 39Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.
AID1763407Inhibition of hedgehog pathway in mouse Shh Light II cells transfected with Renilla luciferase and firefly luciferase incubated for 48 hrs by dual luciferase reporter gene assay2021Bioorganic & medicinal chemistry, 06-01, Volume: 39Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.
AID402394Antifungal activity against Saccharomyces cerevisiae 11381998Journal of natural products, Oct, Volume: 61, Issue:10
DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1.
AID1763411Antiproliferative activity against human DAOY cells assessed as cell viability at 10 to 30 uM incubated for 24 hrs by MTT assay relative to control2021Bioorganic & medicinal chemistry, 06-01, Volume: 39Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.
AID402399Cytotoxicity against mouse M109 cells1998Journal of natural products, Oct, Volume: 61, Issue:10
DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1.
AID402398Antifungal activity against Candida albicans SC53141998Journal of natural products, Oct, Volume: 61, Issue:10
DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's2 (28.57)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.18 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		1.9910dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
veratramine
veratramine: structure. veratramine : A piperidine alkaloid comprising the 14,15,16,17-tetradehydro derivative of veratraman having two hydroxy groups at the 3- and 23-positions.		3.2110piperidine alkaloid
jervine
jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure		2.3920piperidines
solanidine
solanidine: derivative of DIOSGENIN that can rearrange to SOLANINE		3.21103beta-hydroxy-Delta(5)-steroid;
solanid-5-en-3-ol;
steroid alkaloid fundamental parent		plant metabolite;
toxin
diosgenin
[no description available]		3.21103beta-sterol;
hexacyclic triterpenoid;
sapogenin;
spiroketal		antineoplastic agent;
antiviral agent;
apoptosis inducer;
metabolite
cyclopamine
[no description available]		3.6120piperidinesglioma-associated oncogene inhibitor
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		1.9910antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
gdc 0449
HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activity		2.3110benzamides;
monochlorobenzenes;
pyridines;
sulfone		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
ConditionIndicatedRelationship StrengthStudiesTrials
Arachnoidal Cerebellar Sarcoma, Circumscribed
[description not available]		02.3110
Medulloblastoma
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)		02.3110
Goldblatt Syndrome
[description not available]		0210
Hypertension, Renovascular
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.		0210
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