Page last updated: 2024-11-08

speciophylline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

speciophylline: RN refers to (3beta,7alpha,19alpha,20alpha)-isomer; from leaves of Mitragyna inermis (Rubiaceae); structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Mitragyna inermisspecies[no description available]RubiaceaeThe Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH]

Cross-References

ID SourceID
PubMed CID168985
CHEMBL ID5177876
CHEBI ID81204
MeSH IDM0272700

Synonyms (24)

Synonym
4697-68-1
speciophylline
uncarine d
nsc-113094
C17596
methyl (1s,4as,5ar,6s,10as)-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1h-indole]-4-carboxylate
unii-et6rf2pe1p
19-methyl-2-oxoformosanan-16-carboxylic acid, methyl ester
nsc 113094
formosanan-16-carboxylic acid, 19-methyl-2-oxo-, methyl ester, (3beta,7alpha,19alpha,20alpha)-
et6rf2pe1p ,
CHEBI:81204
speciophyllin
uncarin d
speciophylline (uncarine d) (constituent of cat's claw) [dsc]
methyl (3.beta.,7.alpha.,19.alpha.,20.alpha.)-19-methyl-2-oxoformosanan-16-carboxylate
formosanan-16-carboxylic acid, 19-methyl-2-oxo-, methyl ester, (3.beta.,7.alpha.,19.alpha.,20.alpha.)-
CHEMBL5177876
(1's,3s,4a's,5a'r,10a's)-methyl 1'-methyl-2-oxo-1',4a',5',5a',7',8',10',10a'-octahydrospiro[indoline-3,6'-pyrano[3,4-f]indolizine]-4'-carboxylate
Q27155149
uncarined
DTXSID501319083
methyl (3beta,7alpha,19alpha,20alpha)-19-methyl-2-oxoformosanan-16-carboxylate
speciophylline (uncarine d) (constituent of cat's claw)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indolizines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1873065Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth2022European journal of medicinal chemistry, Jul-05, Volume: 237Spiral molecules with antimalarial activities: A review.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.55

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.55 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.55)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]