Compounds > aculeatin a
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aculeatin a

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Description

aculeatin A: antineoplastic from Amomum aculeatum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AmomumgenusA plant genus of the family ZINGIBERACEAE. Members contain aculeatin D, beta-sitosterol, and STIGMASTEROL. Some members have been reclassified to ELETTARIA and other ZINGIBERACEAE.[MeSH]ZingiberaceaeA plant family of the order Zingiberales, subclass Zingiberidae, class Liliopsida. It includes plants which have both flavoring and medicinal properties such as GINGER; turmeric (CURCUMA), and cardamom (ELETTARIA).[MeSH]

Cross-References

ID SourceID
PubMed CID10409797
CHEMBL ID428425
MeSH IDM0452469

Synonyms (5)

Synonym
CHEMBL428425
aculeatins a
(+)-aculeatine d
aculeatin a
(2r,4r,6r)-2-hydroxy-4-tridecyl-5,7-dioxadispiro[5.1.58.26]pentadeca-9,12-dien-11-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID329575Cytotoxicity against human MCF7 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID362707Cytotoxicity against human K562 cells assessed as radioactive thymidine incorporation after 24 hrs2008Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
Enhanced antimalarial activity of novel synthetic aculeatin derivatives.
AID422146Growth inhibition of human MCF7 cells xenografted in NCr nu/nu mouse at 6.25 to 50 mg/kg, ip once daily administered from day 3 to 6 after implantation measured on day 7 by MTT-based hollow-fiber test2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.
AID1873087Antimalarial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells assessed as inhibition of parasite growth incubated for 72 hrs by [3H]-hypoxanthine incorporation assay based liquid scintilla2022European journal of medicinal chemistry, Jul-05, Volume: 237Spiral molecules with antimalarial activities: A review.
AID362469Antimalarial activity against Plasmodium falciparum 3D7 in human erythrocytes after 48hrs by [3H]hypoxanthine uptake2008Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
Enhanced antimalarial activity of novel synthetic aculeatin derivatives.
AID424510Growth inhibition of human MCF7 cells xenografted in NCr nu/nu mouse at 6.25 to 50 mg/kg, sc once daily administered from day 3 to 6 after implantation measured on day 7 by MTT-based hollow-fiber test2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.
AID329583Antitumor activity against human A2780S cells xenografted in mouse at 3 mg/kg relative to control2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID362472Selectivity index, ratio of CC50 for human K562 cells to IC50 for Plasmodium falciparum 3D72008Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
Enhanced antimalarial activity of novel synthetic aculeatin derivatives.
AID329577Inhibition of human Lu1 cells propagated in hollow fibers via intraperitoneal site of immunodeficient mouse at 6.25 to 50 mg/kg after 3 to 6 days2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID1873088Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in human red blood cells assessed as inhibition of parasite growth incubated for 72 hrs by [3H]-hypoxanthine incorporation assay based liquid scintillation counter met2022European journal of medicinal chemistry, Jul-05, Volume: 237Spiral molecules with antimalarial activities: A review.
AID329576Inhibition of human MCF7 cells propagated in hollow fibers via intraperitoneal site of immunodeficient mouse at 6.25 to 50 mg/kg after 3 to 6 days2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID329581Inhibition of human LNCaP cells propagated in hollow fibers via subcutaneous site of immunodeficient mouse at 6.25 to 50 mg/kg after 3 to 6 days2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID329578Inhibition of human LNCaP cells propagated in hollow fibers via intraperitoneal site of immunodeficient mouse at 6.25 to 50 mg/kg after 3 to 6 days2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID329582Antitumor activity against mouse P388 lymphocytic leukemia model at 15 mg/kg, ip relative to control2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID400915Cytotoxicity against Myosarcoma cells2004Journal of natural products, Apr, Volume: 67, Issue:4
New chromanone acids with antibacterial activity from Calophyllum brasiliense.
AID362470Antitoxoplasmal activity against Toxoplasma gondii RH-beta1 in HFF cells assessed as beta-galactosidase activity after 48 to 72 hrs by colorimetric microtiter assay2008Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
Enhanced antimalarial activity of novel synthetic aculeatin derivatives.
AID329580Inhibition of human Lu1 cells propagated in hollow fibers via subcutaneous site of immunodeficient mouse at 6.25 to 50 mg/kg after 3 to 6 days2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID362474Antimalarial activity against Plasmodium falciparum K12008Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
Enhanced antimalarial activity of novel synthetic aculeatin derivatives.
AID329574Cytotoxicity against human LNCaP cells2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID329579Inhibition of human MCF7 cells propagated in hollow fibers via subcutaneous site of immunodeficient mouse at 6.25 to 50 mg/kg after 3 to 6 days2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID329573Cytotoxicity against human Lu1 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
Potential anticancer activity of naturally occurring and semisynthetic derivatives of aculeatins A and B from Amomum aculeatum.
AID362473Selectivity index, ratio of CC50 for human K562 cells to IC50 for Toxoplasma gondii RH-beta12008Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
Enhanced antimalarial activity of novel synthetic aculeatin derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (60.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.10 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.50 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.10)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0410aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.0210C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
podophyllotoxin
Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.		2.0210furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
helenalin
helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure. helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.		2.0210cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		3.4470
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		3.1410taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
dioscin
[no description available]		3.1410hexacyclic triterpenoid;
spiroketal;
spirostanyl glycoside;
trisaccharide derivative		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 1.14.18.1 (tyrosinase) inhibitor;
hepatoprotective agent;
metabolite
speciophylline
speciophylline: RN refers to (3beta,7alpha,19alpha,20alpha)-isomer; from leaves of Mitragyna inermis (Rubiaceae); structure given in first source		3.5110indolizines
erysodine
erysodine: structure given in first source. erysodine : An erythrina alkaloid with formula C18H21NO3 isolated from several erythrina plant species. It is a competitive antagonist of nicotinic acetylcholine receptors and exhibits antiparasitic and insecticidal activities.		3.5110aromatic ether;
diether;
Erythrina alkaloid;
organic heterotetracyclic compound;
phenols		antiparasitic agent;
nicotinic antagonist;
phytogenic insecticide
artenimol
[no description available]		3.5110
erysovine
erysovine: antifeedant from Chinese medicinal herb, Erythrina variegata var. orientalis, against maize weevil Sitophilus zeamais; structure in first source		3.5110
erythraline
erythraline: isolated from Erythrina crista-galli; structure in first source		3.5110alkaloid
mer nf5003f
stachybotrydial: a pancreatic cholesterol esterase inhibitor; also inhibits fucosyltransferase and sialyltransferase; structure in first source		3.5110
1,2,6,7-tetraoxaspiro(7.11)nonadecane
1,2,6,7-tetraoxaspiro(7.11)nonadecane: structure in first source		3.5110
arterolane
arterolane: a trioxolane with antimalarial activity; structure in first source. arterolane : An oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine.		3.5110
silvestrol
silvestrol: isolated from the fruit and twig of Aglaia silvestris. silvestrol : An organic heterotricyclic compound that consists of a 2,3,3a,8b-tetrahydro-H-benzo[b]cyclopenta[d]furan framework substituted by hydroxy groups at positions C-1 and C-8b, a methoxycarbonyl group at C-2, a phenyl group at C-3, a 4-methoxyphenyl group at C-3a, a methoxy group at C-8 and a 1,4-dioxan-2-yloxy group at position C-6 which in turn is substituted by a methoxy group at position 3 and a 1,2-dihydroxyethyl group at position 6. Isolated from Aglaia silvestris, it exhibits antineoplastic activity.		3.1410dioxanes;
ether;
methyl ester;
organic heterotricyclic compound		antineoplastic agent;
metabolite
oz 439
artefenomel: an antimalarial ozonide; structure in first source		3.5110
rka 182
RKA 182: structure in first source		3.5110
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0410
Infections, Plasmodium
[description not available]		03.3310
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		03.3310