| Assay ID | Title | Year | Journal | Article |
|---|
| AID47558 | Inhibition of cytochrome P450 2C19 | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID159112 | Inhibition of the Phospholipase A2 (Lp-PLA2) enzyme in whole human plasma | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID47562 | Inhibition of cytochrome P450 3A4 | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID47559 | Inhibition of cytochrome P450 2C9 | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID88966 | Concentration required to inhibit the production of lyso-PtdCho by the compound during the copper catalyzed oxidation of human LDL | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID159116 | Binding against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in WHHL rabbit plasma (100 nM) | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID47560 | Inhibition of cytochrome P450 2D6 | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID103814 | Inhibitory activity against recombinant human Lp-PLA2 | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID21272 | Permeability of compound was evaluated in an artificial membrane permeability assay | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID159114 | Binding against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in whole human plasma (10 nM) | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID13394 | Oral bioavailability in fed rat | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID21273 | Permeability was determined | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID103966 | Non specific binding effect against Lp-PLA2 was determined in rabbit plasma at 100 nM | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID159113 | Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimated | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID54596 | Inhibitory activity against Cytochrome P450 2D6 | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID9316 | Oral bioavailability in dog | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID8503 | Oral bioavailability in dog | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID54918 | Inhibitory activity against CYP450 3A4 isozyme | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID21738 | Solubility in pure water at pH 4.7 | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID159115 | Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determined | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID13329 | Oral bioavailability in rat | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID103822 | Non specific binding effect against Lp-PLA2 was determined in human plasma at 10 nM | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID159117 | Inhibitory concentration against Lp-PLA2 was estimated 2 hr after administration of 30 mg/Kg in WHHL rabbit | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID47557 | Inhibition of cytochrome P450 1A2 | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| AID13393 | Oral bioavailability in fasted rat | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6
| The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. |
| AID88967 | Concentration required to inhibit the subsequent monocyte chemotaxis by the compound during the copper catalyzed oxidation of human LDL | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |