Compounds > sar 97276
Page last updated: 2024-11-12

sar 97276

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID11377022
CHEMBL ID520613
SCHEMBL ID2017697
MeSH IDM0520665

Synonyms (17)

Synonym
sar97276a
albitiazolium bromide
CHEMBL520613
sar-97276a
3ac0aj4ilp ,
321915-72-4
3,3'-(dodecan-1,12-diyl)bis(5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium) dibromide
albitiazolium bromide [inn]
sar 97276
unii-3ac0aj4ilp
SCHEMBL2017697
DTXSID60185968
1,12-bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecane dibromide
1,12-bis[4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl]dodecanedibromide
Q21400577
2-[3-[12-[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]dodecyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;dibromide
3,3'-(dodecane-1,12-diyl)bis(5-(2-hydroxyethyl)-4-methylthiazol-3-ium) bromide

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
", permanent cationic charges, the flexibility, and lipophilic character of the alkyl chain), the oral bioavailability of these compounds is low."( New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation.
Caldarelli, SA; El Fangour, S; Pellet, A; Périgaud, C; Peyrottes, S; Tran van Ba, C; Vial, HJ; Wein, S, 2013)		0.39
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID724074Therapeutic index, ratio of ED50 for human Jurkat cells to IC50 for Plasmodium falciparum Nigeria infected in human erythrocytes2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation.
AID675865Antimalarial activity against Plasmodium vinckei petteri 279BY infected in ip dosed Swiss mouse assessed as reduction in parasitemia administered QD for 4 days measured on day 52012Journal of medicinal chemistry, May-24, Volume: 55, Issue:10
Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.
AID675864Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs2012Journal of medicinal chemistry, May-24, Volume: 55, Issue:10
Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.
AID447918Antimalarial activity against Plasmodium vinckei petteri 279BY infected in Swiss mice (Mus musculus) assessed as reduction in parasitaemia level at 10 mg/kg, intraperitoneal measured after 4 days2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarials.
AID489741Antimalarial activity against Plasmodium vinckei infected in intraperitoneally dosed mice (Mus musculus)2010Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.
AID675867Ratio of ED50 for Plasmodium vinckei petteri 279BY infected in ip dosed Swiss mouse to ED50 for Plasmodium venckei petteri 279BY infected in po dosed Swiss mouse2012Journal of medicinal chemistry, May-24, Volume: 55, Issue:10
Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.
AID724076Antimalarial activity against Plasmodium vinckei petteri 279BY infected in Swiss mouse administered as ip qd for 4 days measured on day 52013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation.
AID675866Antimalarial activity against Plasmodium vinckei petteri 279BY infected in po dosed Swiss mouse assessed as reduction in parasitemia administered QD for 4 days measured on day 52012Journal of medicinal chemistry, May-24, Volume: 55, Issue:10
Disulfide prodrugs of albitiazolium (T3/SAR97276): synthesis and biological activities.
AID516719Antimalarial activity against Plasmodium falciparum2010Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
Reverse-benzamidine antimalarial agents: design, synthesis, and biological evaluation.
AID367721Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum Nigerian by [3H]hypoxanthine uptake2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents.
AID447917Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigerian2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarials.
AID447919Antimalarial activity against Plasmodium vinckei petteri 279BY infected peroral daily dosed Swiss mice (Mus musculus) assessed as reduction in parasitaemia level measured after 4 days2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
N-substituted bis-C-alkyloxadiazolones as dual effectors: efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarials.
AID724075Cytotoxicity against human Jurkat cells after 24 hrs by [3H]thymidine incorporation assay2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation.
AID1552381Antimalarial activity against Plasmodium falciparum infected in erythrocytes2019Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials.
AID489742Antimalarial activity against Plasmodium vinckei infected in perorally dosed mice (Mus musculus)2010Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.
AID724077Antiplasmodial activity against Plasmodium falciparum Nigeria infected in human erythrocytes assessed as incorporation of [3H]hypoxanthine after 48 hrs2013Journal of medicinal chemistry, Jan-24, Volume: 56, Issue:2
New bis-thiazolium analogues as potential antimalarial agents: design, synthesis, and biological evaluation.
AID489740Antiplasmodial activity against Plasmodium falciparum2010Bioorganic & medicinal chemistry letters, Jul-01, Volume: 20, Issue:13
Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.5220aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.2110aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
artesunate
artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether		2.2110artemisinin derivative;
cyclic acetal;
dicarboxylic acid monoester;
hemisuccinate;
semisynthetic derivative;
sesquiterpenoid		antimalarial;
antineoplastic agent;
ferroptosis inducer
ConditionIndicatedRelationship StrengthStudiesTrials
Parasitemia
The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)		02.0510
Infections, Plasmodium
[description not available]		02.7530
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		14.7530