sar-97276 and Parasitemia

sar-97276 has been researched along with Parasitemia* in 1 studies

Other Studies

1 other study(ies) available for sar-97276 and Parasitemia

Article	Year
Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents. Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3 Within the frame of the design of prodrug candidates to deliver a C-alkylamidine antimalarial agent, we showed that specific O-substitutions were needed on the alkylamidoxime structure. Among the newly synthesized molecules, bis-oxadiazolone and bis-O-methylsulfonylamidoxime derivatives induced a complete clearance of parasitemia in mice after oral administration. Topics: Administration, Oral; Animals; Antimalarials; Antioxidants; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Humans; Malaria; Mice; Models, Chemical; Parasitemia; Plasmodium falciparum; Prodrugs	2009

Article

Year

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents.

Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

Within the frame of the design of prodrug candidates to deliver a C-alkylamidine antimalarial agent, we showed that specific O-substitutions were needed on the alkylamidoxime structure. Among the newly synthesized molecules, bis-oxadiazolone and bis-O-methylsulfonylamidoxime derivatives induced a complete clearance of parasitemia in mice after oral administration.

Topics: Administration, Oral; Animals; Antimalarials; Antioxidants; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Humans; Malaria; Mice; Models, Chemical; Parasitemia; Plasmodium falciparum; Prodrugs

2009