sulfamethoxazole
Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208). sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position. | 3.23 | 1 | 0 | isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic |
bosentan anhydrous
Bosentan: A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS. | 5.66 | 5 | 1 | primary alcohol;
pyrimidines;
sulfonamide | antihypertensive agent;
endothelin receptor antagonist |
ro 46-2005
Ro 46-2005: an orally active non-peptide antagonist of endothelin receptors; structure given in first source | 3.23 | 1 | 0 | | |
tezosentan
tezosentan: structure in first source | 3.23 | 1 | 0 | | |
lu 135252
[no description available] | 3.23 | 1 | 0 | | |
tbc-11251
sitaxsentan: endothelin A receptor antagonist; structure in first source | 3.23 | 1 | 0 | benzodioxoles | |
bq 123
cyclo(Trp-Asp-Pro-Val-Leu): derived from the modification of a natural lead of BE-18257B, an endothelin A receptor antagonist; has neuroprotective activity; amino acid sequence given in first source | 2.13 | 1 | 0 | cyclic peptide | |
ro 46-8443
Ro 46-8443: a non-peptide endothelin ET(B) receptor selective antagonist; structure given in first source | 3.23 | 1 | 0 | | |
ro 48-5033
Ro 48-5033: structure in first source | 4.37 | 4 | 1 | | |
clazosentan
clazosentan: endothelin A receptor antagonist used for cerebral vasospasm; structure in first source; | 3.23 | 1 | 0 | | |
lu 208075
ambrisentan: an ET(A) receptor antagonist and antihypertensive agent; studied for use in pulmonary arterial hypertension | 3.23 | 1 | 0 | diarylmethane | |
bms 193884
[no description available] | 3.23 | 1 | 0 | | |
zibotentan
ZD4054: a potent endothelin receptor A antagonist that inhibits ovarian carcinoma cell proliferation | 3.23 | 1 | 0 | phenylpyridine | |
avosentan
Avosentan: structure in first source | 3.23 | 1 | 0 | | |
macitentan
[no description available] | 3.23 | 1 | 0 | aromatic ether;
organobromine compound;
pyrimidines;
ring assembly;
sulfamides | antihypertensive agent;
endothelin receptor antagonist;
orphan drug |
act-132577
aprocitentan: a macitentan metabolite. ACT-132577 : A member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. | 3.23 | 1 | 0 | aromatic ether;
organobromine compound;
pyrimidines;
sulfamides | antihypertensive agent;
drug metabolite;
endothelin receptor antagonist;
xenobiotic metabolite |