Page last updated: 2024-12-11
oxymorphazone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Protein Interactions
Research Growth
Market Indicators
Description
oxymorphazone: binds irreversibly to opiate receptor sites; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 5490705 |
CHEMBL ID | 351916 |
MeSH ID | M0106643 |
Synonyms (4)
Synonym |
---|
oxymorphazone |
CHEMBL351916 |
(4r,4as,7z,7ar,12bs)-7-hydrazinylidene-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol |
Q7116020 |
Research Excerpts
Overview
Oxymorphazone is a 14-hydroxydihydromorphinone derivative which contains a C-6 hydrazone group. It could serve as an irreversible label for opioid receptors.
Excerpt | Reference | Relevance |
---|---|---|
"Oxymorphazone is a 14-hydroxydihydromorphinone derivative which contains a C-6 hydrazone group and hence could serve as an irreversible label for opioid receptors. " | ( Synthesis and binding of 3H-oxymorphazone to rat brain membranes. Benyhe, S; Borsodi, A; Hosztafi, S; Toth, G; Varga, E, 1987) | 2.01 |
"Oxymorphazone is a 14-hydroxydihydromorphinone derivative which contains C-6 hydrazone group and hence could serve as an irreversible label for opioid receptors. " | ( Preparation of [3H]-oxymorphazone and its binding to rat brain membranes. Borsodi, A; Hosztafi, S; Toth, G; Varga, E, 1986) | 2.04 |
Dosage Studied
Excerpt | Relevance | Reference |
---|---|---|
" Dose-response curves at 1 hr revealed similar potencies of oxymorphone and the derivatives, with the exception of OxyPNPH which was significantly less potent." | ( Irreversible opiate agonists and antagonists. IV. Analgesic actions of 14-hydroxydihydromorphinone hydrazones. Bodnar, RJ; Burks, TF; Clark, JE; Hahn, EF; Pasternak, GW; Williams, CL, 1988) | 0.27 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (19)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID195707 | Percent decrease in activity for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl at dose of 10 nM compared with that of control (6070+/-75 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195702 | The compound was tested in vitro for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of standard at 4 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195706 | Percent decrease in activity for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl and MnCl2 at dose of 4 nM compared with that of control (5840+/-72 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195704 | Percent decrease in activity for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of MnCl2 at dose of 4 nM compared with that of control (4080+/-138 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195709 | Percent decrease in activity for the inhibition of [3H]-Naltrexone in rat brain homogenates in the presence of standard at dose of 10 nM compared with that of control (4930+/-143 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID111971 | Percent analgesia of compound was measured in mice by using tail-flick assay | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195705 | Percent decrease in activity for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl and MnCl2 at dose of 10 nM compared with that of control (5840+/-72 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195694 | The ability of compound was measured to replace [3H]-labeled [D-Ala2, Met5]-enkephalinamide in rat brain homogenates by using [3H]-opiate binding assay | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195697 | The compound was tested in vitro for the inhibition of [3H]-Naltrexone in rat brain homogenates in the presence of MnCl2 at 4 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195710 | Percent decrease in activity for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of standard at dose of 4 nM compared with that of control (4930+/-143 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195708 | Percent decrease in activity for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl at dose of 4 nM compared with that of control (6070+/-75 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195698 | The compound was tested in vitro for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl and MnCl2 at 10 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195703 | Percent decrease in activity for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of MnCl2 at dose of 10 nM compared with that of control (4080+/-138 cpm). | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195712 | The compound was tested in vitro for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl at 4 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195700 | The compound was tested in vitro for the inhibition of [3H]-Naltrexone in rat brain homogenates in the presence of NaCl at 10 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID227642 | The compound was tested in vitro for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of MnCl2 at 10 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID227644 | The compound was tested in vitro for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of standard at 10 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID227643 | The compound was tested in vitro for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl and MnCl2 at 10 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
AID195699 | The compound was tested in vitro for the inhibition of [3H]naltrexone in rat brain homogenates in the presence of NaCl and MnCl2 at 4 nM dose. | 1980 | Journal of medicinal chemistry, Jun, Volume: 23, Issue:6 | Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 10 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 37.21
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (37.21) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 11 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |