Compounds > ostruthin
Page last updated: 2024-11-10

ostruthin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5281420
CHEMBL ID1812645
CHEBI ID69833
SCHEMBL ID2936116
SCHEMBL ID2936121
MeSH IDM0052811

Synonyms (37)

Synonym
coumarin, 6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxy-,(e)-
ostruthine
nsc83434
2h-1-benzopyran-2-one,6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxy-,(e)-
6-[(2e)-3,7-dimethylocta-2,6-dienyl]-7-hydroxy-chromen-2-one
ACON1_001218
coumarin,7-dimethyl-2,6-octadienyl)-7-hydroxy-, (e)-
2h-1-benzopyran-2-one,7-dimethyl-2,6-octadienyl)-7-hydroxy-, (e)-
nsc-83434
6-geranyl-7-hydroxycoumarin
MEGXP0_001198
C09281
148-83-4
ostruthin
6-[(2e)-3,7-dimethylocta-2,6-dienyl]-7-hydroxychromen-2-one
CHEMBL1812645
chebi:69833 ,
xhk3rr9bor ,
nsc 83434
ccris 8087
2h-1-benzopyran-2-one, 6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxy-, (e)-
unii-xhk3rr9bor
coumarin, 6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxy-, (e)-
6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxycoumarin
(e)-6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxy-2h-1-benzopyran-2-one
(e)-6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxycoumarin
6-(3,7-dimethyl-2,6-octadienyl)umbelliferone
ostruthin [mi]
(e)-6-(3,7-dimethylocta-2,6-dien-1-yl)-7-hydroxy-2h-chromen-2-one
SCHEMBL2936116
SCHEMBL2936121
2h-1-benzopyran-2-one,6-[(2e)-3,7-dimethyl-2,6-octadien-1-yl]-7-hydroxy-
6-geranyl-7-hydroxycoumarin, >=95% (lc/ms-elsd)
2h-1-benzopyran-2-one, 6-(3,7-dimethyl-2,6-octadienyl)-7-hydroxy-, (e)- (9ci)
Q21547160
DTXSID601318569
AKOS040735765
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
terpene lactone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID611882Antiproliferative activity in primary rat aortic VSMC assessed as inhibition of serum-induced DNA synthesis pretreated 30 mins prior serum addition measured after 48 hrs by BrdU incorporation assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.
AID611885Cytotoxicity against primary rat aortic VSMC as cell viability at 30 uM by trypan blue exclusion assay (Rvb = 98+/-2%)2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.
AID611886Antiproliferative activity against serum-stimulated primary rat aortic VSMC after 30 mins by resazurin conversion assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.
AID611884Antiproliferative activity against serum-stimulated primary rat aortic VSMC at 30 uM after 30 mins by resazurin conversion assay2011Journal of natural products, Jun-24, Volume: 74, Issue:6
Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's1 (12.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.00 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
coumarin
2H-chromen-2-one: coumarin derivative		6.9410coumarinsfluorescent dye;
human metabolite;
plant metabolite
amlodipine
Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.. amlodipine : A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.		2.1710dihydropyridine;
ethyl ester;
methyl ester;
monochlorobenzenes;
primary amino compound		antihypertensive agent;
calcium channel blocker;
vasodilator agent
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		1.9910ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		1.9910ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
imperatorin
imperatorin: tumor necrosis factor antagonist; furanocoumarin from West African medicinal plant Clausena anisata; structure in Negwer, 5th ed, #3005. imperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.		2.4220psoralensEC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite
osthol
osthol: from Cnidium monnieri and Angelica pubescens (both Apiaceae); structure given in first source		2.0610botanical anti-fungal agent;
coumarins		metabolite
aviprin
aviprin: isolated from Angelica dahurica; structure in first source		2.0610furanocoumarinmetabolite
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9910acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
oxypeucadanin, (s)-(-)-isomer
[no description available]		2.0610epoxide;
furanocoumarin;
lactone		plant metabolite
isopimpinellin
isopimpinellin: from Ruta graveolens & Heracleum lanatum; structure		1.9910psoralens
isoimperatorin
isoimperatorin: tumor necrosis factor antagonist isolated from Glehniae root. isoimperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.		2.0610psoralensEC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite
coriandrin
coriandrin: from Coriandrum sativum		1.9910isocoumarins
bornyl ferulate
bornyl ferulate: structure in first source		710hydroxycinnamic acid
bergamottin
bergamottin: constituent of bergamot oil; structure given in first source		1.9910furanocoumarinmetabolite
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.8740benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.		02.1710
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.		02.1710
Cancer of Skin
[description not available]		01.9910
Skin Neoplasms
Tumors or cancer of the SKIN.		01.9910