Compounds > nectrisine
Page last updated: 2024-11-07

nectrisine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Nectrisine is a natural product with a complex structure containing a pentacyclic core, isolated from the plant *Nectris japonica*. It has been shown to exhibit anti-inflammatory and anti-tumor activities. Studies have focused on understanding its biosynthesis and potential therapeutic applications. Nectrisine’s unique structure and biological activity have made it a target of interest for researchers in the fields of natural product chemistry, medicinal chemistry, and pharmacology.'

nectrisine: produced by the fungus, Nectria lucida F-4490; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122106
MeSH IDM0156943

Synonyms (15)

Synonym
2h-pyrrole-3,4-diol, 3,4-dihydro-2-(hydroxymethyl)-, (2r-(2-alpha,3-beta,4-alpha))-
2h-pyrrole, 3,4-diol, 3,4-dihydro-2-(hydroxymethyl)-, (3r-(3alpha,4beta,5alpha))-
wf 4490
nectrisine
fr 900483
(2r-(2-alpha,3-beta,4-alpha))-3,4-dihydro-2-(hydroxymethyl)-2h-pyrrole-3,4-diol
3,4-dihydro-2-(hydroxymethyl)-,[2r-(2.alpha.,3.beta.,4.alpha.)]-2h-pyrrole-3,4-diol
2h-pyrrole-3,4-diol
(2r,3r,4s)-2-(hydroxymethyl)-3,4-dihydro-2h-pyrrole-3,4-diol
2h-pyrrole-3,4-diol, 3,4-dihydro-2-(hydroxymethyl)-, (2r,3r,4r)-
108692-47-3
3,4-dihydroxy-2-(hydroxymethyl)pyrrolidine
3,4-dihydroxy-5-hydroxymethyl-1-pyrroline
DTXSID80910830
136615-83-3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.57 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.77 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.		2.0410L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		7.1310metal allergen;
nickel group element atom;
platinum group metal atom
1-deoxynojirimycin
1-deoxy-nojirimycin: structure in first source. duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.		1.99102-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid		anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
castanospermine
castanospermine: indolizidine alkaloid from seeds of Australian legume, Castanospermum australe. castanospermine : A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).		1.9910indolizidine alkaloidanti-HIV-1 agent;
anti-inflammatory agent;
EC 3.2.1.* (glycosidase) inhibitor;
metabolite
xylose
xylopyranose: structure in first source		2.1110D-xylose
xylulose-5-phosphate, (d)-isomer
D-xylulose 5-phosphate : The D-enantiomer of xylulose 5-phosphate.		2.1110xylulose 5-phosphateEscherichia coli metabolite;
mouse metabolite
arabinose
[no description available]		2.0110L-arabinoseEscherichia coli metabolite;
mouse metabolite
ribose
ribopyranose : The pyranose form of ribose.		2.4520D-ribose;
ribopyranose
radicamine b
radicamine B: structure in first source		7.0410
ConditionIndicatedRelationship StrengthStudiesTrials