mebhydroline profile

Mebhydroline is a synthetic phenylpiperazine derivative. It was initially synthesized and patented in 1959 as a potential antihistamine and anti-emetic agent. However, its pharmacological profile revealed a significant affinity for serotonin receptors, particularly 5-HT2A receptors. This has led to research exploring its potential therapeutic effects in various conditions, including anxiety, depression, and addiction. Mebhydroline is also recognized for its unique pharmacodynamic properties, including the ability to enhance dopamine release in the brain. The compound is known to exhibit both agonist and antagonist activity at different serotonin receptor subtypes, making it a complex and intriguing target for further research. Its potential therapeutic applications are currently being investigated in preclinical models, with ongoing efforts to understand its precise mechanisms of action and potential side effects.'

mebhydroline: see also rcored for mebhydrolin 1,5-naphthalenedisulfonate, RN: 6153-33-9 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	22530
CHEMBL ID	1625607
CHEBI ID	135144
SCHEMBL ID	29802
MeSH ID	M0046467

Synonym
mebhydroline
mebhydroline [inn-french]
mebhidrolina [inn-spanish]
mebhydrolin [inn:ban]
mebhydrolinum [inn-latin]
5-benzyl-1,3,4,5-tetrahydro-2-methyl-2h-pyrido(4,3-b)indole
einecs 208-364-4
BRD-K29713308-077-02-5
3-benzyl-6-methyl-1,2,3,4-tetrahydro-.gamma.-carboline
mebhydrolin
ENAMINE_003214
OPREA1_493964
5-benzyl-2-methyl-2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole
BAS 07119675
AB00053596
CHEBI:135144
AKOS000115947
HMS1403C02
5-benzyl-2-methyl-3,4-dihydro-1h-pyrido[4,3-b]indole
bexidal (tn)
D08161
mebhydrolin (inn)
524-81-2
1h-pyrido[4,3-b]indole, 2,3,4,5-tetrahydro-2-methyl-5-(phenylmethyl)-
9suk9b7xvy ,
nsc 757830
mebhydrolinum
mebhidrolina
unii-9suk9b7xvy
ST077696
5-benzyl-2-methyl-1h,2h,3h,4h,5h-pyrido[4,3-b]indole
EN300-02843
nsc-757830
CCG-25295
bexidal
CHEMBL1625607
mebhydrolin [inn]
mebhydrolin [who-dd]
mebhydrolin [mart.]
mebhydroline [mi]
MLS006011579
smr000097302
SCHEMBL29802
DTXSID5048558
5-benzyl-1,3,4,5-tetrahydro-2-methyl-2h-pyrido[4,3-b]indole
FQQIIPAOSKSOJM-UHFFFAOYSA-N
5-benzyl-2-methyl-2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole #
AB00053596_15
SBI-0051644.P002
CS-0013654
HY-B1303A
Z56841337
STL554133
FT-0737366
DB13808
Q1994982
BRD-K29713308-077-04-1
BRD-K29713308-077-03-3
NCGC00085849-02
MS-23933

Excerpt	Reference	Relevance
"The mebhydroline treatment's superiority over placebo was shown statistically at the 95% confidence level for the symptoms itchy nose in study A and for nasal congestion in study B."	( Three explorative studies on the efficacy of the antihistamine mebhydroline (Omeril). Lenders, H; Pabst, G; Reh, C; Ulbrich, E; Waitzinger, J, 1995)	1.01

Class	Description
indoles	Any compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Mebhydrolin H1-Antihistamine Action	8	7

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	35.4813	0.0096	10.5250	35.4813	AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
virion membrane	Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (42.86)	18.7374
1990's	3 (21.43)	18.2507
2000's	2 (14.29)	29.6817
2010's	2 (14.29)	24.3611
2020's	1 (7.14)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	4 (26.67%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	4 (26.67%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (46.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
formic acid formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.	2.03	1	0	monocarboxylic acid	antibacterial agent; astringent; metabolite; protic solvent; solvent
astemizole Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.. astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.	1.98	1	0	benzimidazoles; piperidines	anti-allergic agent; anticoronaviral agent; H1-receptor antagonist
chlorpromazine Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.	3.35	1	1	organochlorine compound; phenothiazines; tertiary amine	anticoronaviral agent; antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; phenothiazine antipsychotic drug
diazepam Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.	1.96	1	0	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; environmental contaminant; sedative; xenobiotic
promethazine Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.. promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.	3.35	1	1	phenothiazines; tertiary amine	anti-allergic agent; anticoronaviral agent; antiemetic; antipruritic drug; H1-receptor antagonist; local anaesthetic; sedative
lithium carbonate Lithium Carbonate: A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.	1.96	1	0	carbonate salt; lithium salt	antimanic drug
dimethindene Dimethindene: A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.	3.35	1	1	indene
metaperiodate Periodic Acid: A strong oxidizing agent.	2.03	1	0	iodine oxoacid
metaperiodate metaperiodate: RN given refers to periodic acid, Na salt; structure. periodate : A monovalent inorganic anion obtained by deprotonation of periodic acid.	2.03	1	0	iodine oxoanion; monovalent inorganic anion
trimethoprim, sulfamethoxazole drug combination Trimethoprim, Sulfamethoxazole Drug Combination: A drug combination with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.. co-trimoxazole : A two-component mixture comprising trimethoprim and sulfamethoxazole.	1.98	1	0
lithium Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	1.96	1	0	alkali metal atom

Condition	Relationship Strength	Studies	Trials
Encephalitis, Polio [description not available]	2.06	1	0
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1	0
Anemia, Fanconi [description not available]	2.13	1	0
Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	2.13	1	0
Alloxan Diabetes [description not available]	2.31	1	0
Diabetes Mellitus, Adult-Onset [description not available]	2.31	1	0
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.31	1	0
Dermatitis Medicamentosa [description not available]	2.4	2	0
Exanthem [description not available]	2.01	1	0
Exanthema Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.	2.01	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.96	1	0
Behavior Disorders [description not available]	1.96	1	0
Mental Disorders Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.	1.96	1	0
Agranulocytosis A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).	1.96	1	0
Hay Fever [description not available]	3.77	2	1
Rhinitis, Allergic, Seasonal Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.	3.77	2	1
Acute Liver Injury, Drug-Induced [description not available]	1.98	1	0
Palmoplantaris Pustulosis [description not available]	1.98	1	0
Thrombopenia [description not available]	1.98	1	0
Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	1.98	1	0
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	1.98	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	1.98	1	0
Chronic Illness [description not available]	1.98	1	0
Recrudescence [description not available]	1.98	1	0
Bacterial Disease [description not available]	1.98	1	0
Nasal Catarrh [description not available]	1.98	1	0
Pus [description not available]	1.98	1	0
Rhinitis, Allergic, Nonseasonal [description not available]	1.98	1	0
Bacterial Infections Infections by bacteria, general or unspecified.	1.98	1	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	1.98	1	0
Rhinitis Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.	1.98	1	0
Rhinitis, Allergic, Perennial Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.	1.98	1	0
Dermatitis Any inflammation of the skin.	3.35	1	1
Bullous Dermatoses [description not available]	1.97	1	0

mebhydroline

Description

Cross-References

Synonyms (60)

Research Excerpts

Treatment

Drug Classes (1)

Pathways (1)

Protein Targets (1)

Potency Measurements

Ceullar Components (1)

Bioassays (2)

Research

Studies (14)

Market Indicators

Research Demand Index: 66.99

Study Types