hemanthidine and Leukemia-L5178

hemanthidine has been researched along with Leukemia-L5178* in 1 studies

Other Studies

1 other study(ies) available for hemanthidine and Leukemia-L5178

Article	Year
Antiproliferative amaryllidaceae alkaloids isolated from the bulbs of Sprekelia formosissima and Hymenocallis x festalis. Planta medica, 2002, Volume: 68, Issue:5 Seven alkaloids were isolated from Sprekelia formosissima, and five from Hymenocallis x festalis. Tazettine, lycorine, haemanthidine and haemanthamine were evaluated for antiproliferative and multidrug resistance (mdr) reversing activity on mouse lymphoma cells. Lycorine, haemanthidine and haemanthamine displayed pronounced cell growth inhibitory activities against both drug-sensitive and drug-resistant cell lines, but did not significantly inhibit mdr-1 p-glycoprotein. Thus, the tested alkaloids are apparently not substrates for the mdr efflux pump. Assays for interactions with DNA and RNA revealed that the antiproliferative effects of lycorine and haemanthamine result from their complex formation with RNA. Topics: Alkaloids; Amaryllidaceae Alkaloids; Aniline Compounds; Animals; Antineoplastic Agents, Phytogenic; Dioxoles; DNA; Drug Resistance, Multiple; Leukemia L5178; Magnoliopsida; Mice; Molecular Structure; Nucleic Acid Denaturation; Phenanthridines; Plant Stems; RNA, Transfer; Tumor Cells, Cultured; Verapamil	2002

Article

Year

Antiproliferative amaryllidaceae alkaloids isolated from the bulbs of Sprekelia formosissima and Hymenocallis x festalis.

Planta medica, 2002, Volume: 68, Issue:5

Seven alkaloids were isolated from Sprekelia formosissima, and five from Hymenocallis x festalis. Tazettine, lycorine, haemanthidine and haemanthamine were evaluated for antiproliferative and multidrug resistance (mdr) reversing activity on mouse lymphoma cells. Lycorine, haemanthidine and haemanthamine displayed pronounced cell growth inhibitory activities against both drug-sensitive and drug-resistant cell lines, but did not significantly inhibit mdr-1 p-glycoprotein. Thus, the tested alkaloids are apparently not substrates for the mdr efflux pump. Assays for interactions with DNA and RNA revealed that the antiproliferative effects of lycorine and haemanthamine result from their complex formation with RNA.

Topics: Alkaloids; Amaryllidaceae Alkaloids; Aniline Compounds; Animals; Antineoplastic Agents, Phytogenic; Dioxoles; DNA; Drug Resistance, Multiple; Leukemia L5178; Magnoliopsida; Mice; Molecular Structure; Nucleic Acid Denaturation; Phenanthridines; Plant Stems; RNA, Transfer; Tumor Cells, Cultured; Verapamil

2002