Compounds > etamiphylline
Page last updated: 2024-12-06

etamiphylline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Etamiphylline is a methylxanthine derivative that acts as a bronchodilator and phosphodiesterase inhibitor. It is synthesized through chemical modification of theophylline, a naturally occurring xanthine alkaloid. Etamiphylline is primarily used to treat asthma and chronic obstructive pulmonary disease (COPD) by relaxing airway smooth muscle and reducing airway inflammation. Its effects are attributed to its ability to inhibit phosphodiesterase enzymes, which leads to increased levels of cyclic adenosine monophosphate (cAMP) in the body. cAMP is a signaling molecule that plays a crucial role in smooth muscle relaxation and inflammation modulation. Etamiphylline has been studied extensively for its therapeutic potential in respiratory diseases, with particular interest in its ability to improve lung function and reduce symptoms. Its unique pharmacological properties, including its bronchodilatory effect and anti-inflammatory activity, make it a valuable therapeutic option for patients with respiratory conditions.'

etamiphylline: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID28329
CHEMBL ID2104264
CHEBI ID135157
SCHEMBL ID355304
MeSH IDM0050953

Synonyms (86)

Synonym
1h-purine-2,6-dione, 7-[2-(diethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-
314-35-2
diethylaminoethyltheophylline
etamiphyllin
milliphylline
1h-purine-2, 7-[2-(diethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-
r-3588
etaminophylline
7-[(diethylamino)ethyl]theophylline
solufilina
nsc-38348
parephyllin
diaethylaminoaethyl-theophyllin
etamiphylline
soluphyline
queryl
theophylline, 7-[2-(diethylamino)ethyl]-
camphophyline
7-[2-(diethylamino)ethyl]-1,3-dimethylxanthine
millophyline
1,3-dimethyl-7-[2-(diethylamino)ethyl]xanthine
nsc38348
corafil
7-[2-(diethylamino)ethyl]theophylline
etamiphylline (inn)
D07378
diethylaminoethyl theophylline
nsc 38348
7-(diethylaminoethyl)theophylline
7-(beta-diethylaminoethyl)theophylline
etamifilina [inn-spanish]
etamiphylline [inn-french]
1,3-dimethyl-7-(2-(diethylamino)ethyl)xanthine
7-(2-(diethylamino)ethyl)-1,3-dimethylxanthine
millophylline
7-(2-diethylaminoethyl)theophylline
7-(2-(diethylamino)ethyl)theophylline
etamiphyllin [inn]
etamifillina [dcit]
brn 0291098
einecs 206-244-6
theophylline, 7-(2-diethylamino)ethyl-
1h-purine-2,6-dione, 7-(2-(diethylamino)ethyl)-3,7-dihydro-1,3-dimethyl-
diaethylaminoaethyl-theophyllin [german]
etamiphyllinum [inn-latin]
CHEBI:135157
nsc_28329
cas_314-35-2
bdbm82014
etamifilina
etamifillina
221a91bq2s ,
unii-221a91bq2s
etamiphyllinum
4-26-00-02409 (beilstein handbook reference)
59547-58-9
diethylaminoethyltheophylline heparinate
etamiphyllin heparinate
milheparin
7-[2-(diethylamino)ethyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1h-purine-2,6-dione
F3229-0069
CHEMBL2104264
dietamiphylline
etamiphyllin [who-dd]
etamiphyllin [mi]
etamiphylline [inn]
SCHEMBL355304
AWKLBIOQCIORSB-UHFFFAOYSA-N
theophylline, 7-(2-(diethylamino)ethyl)-
7-[2-(diethylamino)ethyl]-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione #
7-[2-(diethylamino)ethyl]-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione
AKOS024481061
FT-0699597
VU0606073-1
7-(2-(diethylamino)ethyl)-theophylline
{7-[(diethylamino)ethyl]theophylline}
diaethylaminoaethyl-theophyllin(german)
theophylline, {7-[2-(diethylamino)ethyl]-}
{7-[2-(diethylamino)ethyl]-1,} 3-dimethylxanthine
1, {3-dimethyl-7-[2-(diethylamino)ethyl]xanthine}
{7-[2-(diethylamino)ethyl]theophylline}
Q5402412
DB13592
7-[2-(diethylamino)ethyl]-1,3-dimethylpurine-2,6-dione
DTXSID10861866
7-(2-(diethylamino)ethyl)-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione

Research Excerpts

Overview

Etamiphylline seems to be a rather weaker bronchodilator than theophylline when administered orally.

ExcerptReferenceRelevance
"Etamiphylline seems to be a rather weaker bronchodilator than theophylline when administered orally."( [Comparative study of the effect of a single oral dose of theophylline and etamiphyllin in children with asthma].
Labayru, MT; Vázquez, C, 1984)		0.99
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oxopurine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (50.00)18.7374
1990's2 (20.00)18.2507
2000's2 (20.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.99 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.99)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (18.18%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (18.18%)4.05%
Observational0 (0.00%)0.25%
Other7 (63.64%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
albuterol
Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).		1.9610phenols;
phenylethanolamines;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic
theophylline
[no description available]		5.07101dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
amitriptyline
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.. amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.		1.9810carbotricyclic compound;
tertiary amine		adrenergic uptake inhibitor;
antidepressant;
environmental contaminant;
tropomyosin-related kinase B receptor agonist;
xenobiotic
almitrine
Almitrine: A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.. almitrine : A triamino-1,3,5-triazine compound having allylamino substituents at the 2- and 4-positions and a 4-(bis(p-fluorophenyl)methyl)-1-piperazinyl group at the 6-position.		6.9610piperazines;
triamino-1,3,5-triazine		central nervous system stimulant
ConditionIndicatedRelationship StrengthStudiesTrials
Asthma, Bronchial
[description not available]		04.0431
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		09.0431
Aura
[description not available]		01.9810
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)		01.9810
Decerebrate Posturing
[description not available]		01.9610